Best Practices for Oligonucleotide Analysis Using Ion-Pair Reversed-Phase (IP-RP) Liquid Chromatography – Columns and Chemistries

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Martin Gilar, Nicholas J. Zampa
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Application Notes
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In support of customers working on oligonucleotides, Waters offers these critical best practices to ensure consistent high-performance IP-RP liquid chromatographic separations for oligonucleotide analysis. Robust methods are critical to delivering high-quality oligonucleotides in diagnostic or therapeutic applications. For example, high-quality oligonucleotide primers and probes are essential for accurate PCR-based diagnostic assays, including those for COVID-19.

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