Development of a Robust Method for Analysis of Aspirin and Related Substances Using a Statistical Software and Quality-by-Design Approach

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Margaret Maziarz, Paul D. Rainville, Tran Pham
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Application Notes
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In this application note, we develop a MS compatible method for aspirin API and its related substances using a Fusion QbD method development software. Fusion QbD method development software is applied to perform DoE studies, statistical data analysis, and mathematical modeling for an optimum and robust method. Experiments are run on an ACQUITY Arc System integrated with PDA and ACQUITY QDa detectors, controlled by Empower Data Chromatography Software (CDS). The final method separates all analytes of interests using MS compatible mobile phase and is suitable for the analysis of aspirin tablet formulations. 

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