Somatostatin Analogue Catabolite Screening and Identification Using Vion IMS QTof with WebMetabase

Library Number:
APNT135028802
Part Number:
720006586EN
Author(s):
Mark D. Wrona, Jayne M. Kirk, Ismael Zamora, Tatiana Radchenko, Anna Escola, Antoni Riera, Russell J. Mortishire-Smith
Source:
Waters, Lead Molecular Design, S.L., The Barcelona Institute of Science and Technology
Content Type:
Application Notes
Content Subtype:
Application Notes
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ACQUITY UPLC I-Class System

In this application note, several serum samples were analyzed using ion mobility enabled high resolution mass spectrometry.

Data were processed using the software packages Mass-MetaSite and WebMetabase to automatically detect and visualize peptide catabolites. When combined with the accuracy and selectivity of HDMSE acquired data (ion mobility enhanced HRMS data independent acquisition), this allows the confident identification and tracking of catabolites.


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