Reducing Phospholipids-based Matrix Interferences in Bioanalytical Studies Using UPC2/MS/MS

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Jennifer L. Simeone and Paul D. Rainville
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Using UPC2, it is possible to easily and effectively separate compounds of interest (i.e., hydrophobic drugs like clopidogrel) from coeluting phospholipids. This was achieved with minimal method development time or advanced sample preparation techniques. The addition of UPC2 in a bioanalytical laboratory provides an orthogonal technique that offers an effective way to reduce or prevent matrix effects arising from coelution of phospholipids with hydrophobic compounds.

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