Transitioning Existing LC Methods to New Technologies: Choosing a Liquid Chromatography Platform for 2012

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White Papers

Analytical laboratories face the continual challenge of balancing investment in new technology – to improve throughput and performance – with the need to run existing methods and tests to support current production. High Performance Liquid Chromatography (HPLC) is one of these key analytical technologies that has become a major tool for food safety testing, life science studies, and pharmaceutical, environmental and chemical analysis.

The convergence of two trends – new methods being developed on new LC platforms in product development piplines, and the need for quality control laboratories to also make similar technology investments to enable them to run the methods that will be required to release new products – leaves QC lab managers at a critical decision point with respect to investing in a platform for the future.

In this paper, we demonstrate that a new LC platform, the ACQUITY UPLC System using UltraPerformance LC (UPLC) technology, can be used to run these legacy methods. We will then demonstrate the stepwise transfer of a legacy method to a short, small particle column for greatly improved throughput with equivalent resolution. Finally, we will demonstrate transfer of the legacy method to a long, small particle column for improved throughput with increased resolution.

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