Rapid Qualitative Analysis and Absolute Quantification of Plasma Proteins Using SONAR with Biognosys PQ500 for Proteomic Clinical Research Studies

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Christopher J. Hughes, Sarah Lennon, Lee A. Gethings, Florian Marty, Sebastian Müller, Lukas Reiter, and Robert S. Plumb
Waters, Biognosys AG
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This study highlights the qualitative and quantitative advantages of SONAR for high throughput proteomics.

The implementation of a scanning quadrupole with SONAR acquisitions allow data to be acquired at a faster rate, therefore providing high numbers of protein identifications with higher quantitative precision. A combined workflow with the PQ500 kit demonstrates absolute quantification using the DIA approach, which overcomes the technical challenges provided by traditional, targeted MS schema.

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