The application of pesticides is strictly regulated, and their residues in food and the environment are closely monitored. There are many multi-residue pesticide screening methods available for foods and vegetables, such as the AOAC Official Method 2007.01. However, there are limitations to these methods when applied to dried botanicals, especially resinous hemp-like dried botanicals, due to their complex sample matrix. More intensive sample cleanup may be needed during sample preparation for multiresidue pesticide screening in dried botanicals.
Tandem mass spectrometry (MS/MS), such as the triple quadrupole MS, is the detector of choice in the multi-residue pesticide screening analysis. This is because its high detection selectivity and sensitivity allows for the screening of hundreds of pesticides at low concentration levels (ppb) in a single analysis. Both LC-MS/MS and GC-MS/MS are commonly used for multi-residue pesticide screening since some pesticides are only amenable to either LC or GC.
In this technology brief, learn how the Xevo TQ-S micro and APGC enables multi-residue pesticide analyses for both LC and GC amenable compounds on a single MS system.