Characterization of Impurities in the Fungicide Flutriafol Using UNIFI
and UPLC-ToF-MS(E)

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Marian Twohig, Michael O’Leary, Peter Lee, and John McCauley
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Application Notes
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Application Notes
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Flutriafol is a triazole fungicide that is used in the treatment of a broad spectrum of diseases in cereal crops. During the development process, different routes of synthesis may be evaluated, each producing its own distinct impurity profile. It is critical that these synthesis routes are thoroughly investigated with an aim to identify (or elucidate) relevant impurities alerted by the threshold criteria. The profiling, identification, and quantification of impurities plays a critical role at all stages of both the pesticide development and manufacturing processes, and are essential requirements for the registration of crop protection products. Impurities in agrochemical products are regulated in order to ensure product safety and compliance. The structure of impurities present at or greater than 0.1% in the technical grade active substance must be identified to ensure that the overall safety of the formulated product is well understood. Impurities of toxicological significance are of particular interest. In this application note, the ACQUITY UPLC I-Class System coupled to the Xevo G2-XS QTof and PDA Detector were used to analyze technical-grade flutriafol material. The Screening Platform Solution with UNIFI was used to screen the sample and expedite the discovery of unknown components of interest, as well as to confirm the presence of the active ingredient.

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