Improving the Productivity in Isolating a Naturally Occurring Bioactive Compound Using Supercritical Fluid Extraction and Preparative Supercritical Fluid Chromatography

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John McCauley, Jo-Ann Jablonski, Andrew Aubin, and Rui Chen
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Application Notes
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In this application note, we have demonstrated employing SFE and prep SFC to holistically improve the productivity in isolating a low-polarity, bioactive compound from a complex natural product extract. The SFE alleviated the sample complexity prior to analysis and purification, thereby improving sample loading and reducing solvent use in the ensuing chromatography. The SFE extract also lends itself well for SFC analysis and purification.

The supercritical fluid-based techniques, SFE and SFC, augment the conventional toolbox for natural product research by offering unique selectivity in both extraction and chromatography; and empower laboratories and manufacturers in pharmaceutical, traditional medicine, cosmetics and personal care products, nutraceutical, and dietary supplement industries for more efficient and more cost-effective natural product isolation and purification.

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