A Multidimensional Lipidomics Method: HILIC Coupled with Ion Mobility Enabled Time-of-Flight Mass Spectrometry

Library Number:
APNT134741818
Part Number:
720004704EN
Author(s):
Giuseppe Astarita, Jeremy Netto, Giorgis Isaac, Marc V. Gorenstein, Mark Ritchie, James Langridge
Source:
Waters
Content Type:
Application Notes
Content Subtype:
Application Notes
Related Products:
 
 
SYNAPT G2-S HDMS
 
 
 

A HILIC-UPLC separation with ion mobility-Tof MS (SYNAPT G2-S HDMS) enables a multi-dimensional separation of complex biological mixtures, enhancing the information obtained from profiling lipids. HDMS Compare Software and TransOmics Informatics facilitate the comparison of the biological samples.

The combination of liquid chromatography, ion mobility, and oa-Tof mass spectrometry is a multidimensional separation strategy capable of analyzing complex biological mixtures to a depth not previously possible, enhancing the detail obtained from lipidomic profiling.


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