Two-Dimensional Liquid Chromatography for Quantification and MS Analysis of Monoclonal Antibodies in Complex Samples

Library Number:
APNT134675660
Part Number:
720004304en
Author(s):
Sean M. McCarthy, Thomas E. Wheat, Ying Qing Yu, Jeffrey R. Mazzeo
Content Type:
Application Notes
Content Subtype:
Application Notes
Related Products:
 
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Using the ACQUITY UPLC H-Class Bio System with 2D technology, a method was developed to determine monoclonal antibody concentration and mass profile from a single injection. The system delivered the necessary reproducibility in terms of retention time, recovery, and response for samples from complex matrices using both UV and MS detection.


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