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Establishing an Integrated Peptide Attribute Profiling and Monitoring Workflow for Improved Productivity and Confidence

Library Number:
APNT135024760
Part Number:
720006602EN
Author(s):
Nilini Ranbaduge, Min Du, Ying Qing Yu, and Weibin Chen
Source:
Waters
Content Type:
Application Notes
Content Subtype:
Application Notes
Related Products:
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Peptide Mapping & Peptide Analysis
 
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BioAccord LC-MS System for Biopharmaceuticals
Abstract / Summary

In this application note, we demonstrate peptide mapping and monitoring capabilities of the BioAccord System using forced degradation study of a monoclonal antibody (mAb) as a case study.

The BioAccord System controlled by compliant-ready UNIFI Software is purposefully designed with integrated methods for routine therapeutic protein analysis. It can perform routine peptide characterization and accurate mass screening for CQA monitoring. The seamless integration of the two peptide analyses through the custom library feature is an effective way of transferring knowledge from characterization to monitoring that can be deployed across different analytical laboratory settings.

Further, the SmartMS System with intuitive informatics control (with promoted tune parameters, automated instrument health status monitoring, and calibration) provides a robust MS system suitable for users with any skill level.


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