Using Empower 3 Software for Monitoring Synthetic Peptide Impurities with an ACQUITY QDa Detector for Improved Confidence in Analysis

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Brooke M. Koshel, Robert E. Birdsall, and Ying Qing Yu
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In this study, eledoisin, a vasodilator, is used as a clinically relevant sample to demonstrate how the ACQUITY QDa Detector with Empower 3 Software can be used for synthetic peptide impurity monitoring.

Eledoisin impurities can be documented via traditional optical-based methods, but by incorporating the ACQUITY QDa Detector, co-elutions can be realized. This strategy demonstrates the ability to improve confidence in a manufacturing environment by combining optical detection and orthogonal mass detection into a single workflow.

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