Rapid Screening of Skin Lightening Products for the Corticosteroid Clobetasol Propionate Using Direct Analysis in Real Time (DART) with Mass Detection

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Marian Twohig, Kari Organtini, and Chris Stumpf
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Application Notes
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Application Notes
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Skin whitening/lightening agents in cosmetics are often used to produce a more even skin tone, usually to the face and neck, but sometimes they can be used more extensively over larger areas of skin. The use of pharmaceutical active ingredients (AIs) such as corticosteroids is prohibited for use in cosmetics due to the potential undesirable side effects that can occur.

Regardless of the regulations against using corticosteroids in cosmetics without a prescription, they can still be found in cosmetics marketed as skin lightening products, due to their effectiveness

In this application note we describe a powerful detection method for the rapid qualitative determination of active ingredients (AIs) and other ingredients in cosmetics samples using a direct ionization technique with mass detection. The direct analysis of cosmetic samples using DART coupled with the ACQUITY QDa Mass Detector provides molecular ion information while allowing samples to be analyzed very rapidly and without the need for time-consuming sample preparation or chromatographic method development.

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