High Sensitivity Intact Mass Analysis of Antibodies (IgG1) Using ionKey/MS

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Gregory T. Roman, Henry Shion, James P. Murphy, Weibin Chen
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The ionKey/MS System consisting of the ACQUITY UPLC M-Class System, ionKey Source, and the Xevo G2-XS QTof provides high sensitivity for biotherapeutic applications. Data from this configuration can be processed in UNIFI® Scientific Information System to provide an automated solution that reduces human error in data workup.

Results from an intact IgG1 mAb mass analysis were used to illustrate the sensitivity capabilities that can help biopharmaceutical laboratories extend precious samples, and detect low level glycoforms.

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