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Localized Conformation Analysis of Mutated Human IgG1 by HDX MS and nanoDSC

Library Number:
APNT134661731
Part Number:
720004224en
Author(s):
Waters
Source:
Waters
Content Type:
Application Notes
Content Subtype:
Application Notes
Related Products:
Xevo G2 QTof
 
Xevo G2 QTof
 
Hydrogen Deuterium Exchange with Mass Spec (HDX-MS)
 
ACQUITY UPLC M-Class System with HDX Technology
Abstract / Summary

This technology brief describes the process of probing mAb conformation change caused by amino acid mutation using both Hydrogen Deuterium Exchange Mass Spectrometry (HDX MS, or HXMS) and nano Differential Scanning Calorimetry (DSC) technologies.

 

***nanoACQUITY UPLC applications readily transfer to the ACQUITY UPLC M-Class System***


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720004224en PDF 1342.86kB