Purification Solutions

For Purification Challenges, the Prescription is Waters

Chemistry purification laboratories demand variable sample throughput capabilities. The evolving demands placed upon purification chemists require access to solutions that deliver efficiency and scalability with ease. What’s needed: a comprehensive and flexible portfolio that enables substantial increases in throughput and flexibility, with an added dose of system robustness.

Waters’ purification solutions cover a wide range of scale and configurability to meet today’s needs and tomorrow’s opportunities.

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Overview

Application Notes

Small-scale Isolation

While isolating small amounts of sample, Waters small scale isolation solution increases efficiency and throughput, enabling chemists to perform downstream analyses easily and effectively.

Waters Fraction Manager – Analytical

Isolate and recover small samples for additional analyses with greater efficiency
Increase recovery when separating even the most complex samples
Ideally suited for systems with flow rates up to 5 mL/min.

Bench-scale Purification

Waters’ comprehensive and flexible portfolio provides a wide range of scale and throughput capabilities. Whether requiring single sample or high-throughput purification, Waters has the proven solutions to meet a laboratory’s purification requirements.

Preparative HPLC

From semi-automated modular systems to fully automated mass-directed systems, Waters’ solutions are fully adaptable.

Prep 150 LC System

A simple solution ideal for simple purification needs
Quickly process any sample for high purity and recovery

AutoPurification LC Prep System

Sophisticated solution for complex purification needs
Maximize productivity with mass-directed purification to efficiently target the compound of interest
Automate the purification process to accelerate production of drug candidates
Easily integrate mass-directed purification

Preparative SFC

Waters’ scalable, environmentally friendly systems satisfy the most challenging purification needs while minimizing costs.

Prep 15 SFC Purification System

Automated sample handling accommodates both sample injection and fraction collection within a single, open-bed format
Improve detection sensitivity and peak tracking while interpreting and comparing complex data
Versatile configurations to meet any need

Prep 150 AP SFC System

Leverage automated sample handling, column switching, fraction collection and tracking for fast separations, high resolution, and high throughput
Support a robust, efficient and cost-effective open access environment in any purification lab
Gain superior fraction recovery rates for reduced solvent evaporation time and processing costs

Prep 150 Mgm SFC System

Ideally designed for high-throughput, semi-prep to preparative scale purifications made for repeat injection
Easily operate at higher flow rates than traditional HPLC without significant increase in back pressure
High speed SFC purification and improved resolution of compounds for higher purity isolations

Prep 350 SFC System

For large scale purification: from 100g to kilogram scale
Ideally suited for large compound campaigns
Modified stream injection improves sample loading without peak distortion caused by strong solvent effects
Stacked injection capability improves isocratic purification productivity

Preparative (Purification) HPLC Columns

Benefit from Waters’ rigorous validation testing for the highest levels of consistency and reproducibility
Increase productivity with extended column lifetimes and high mass loading capacity
Easily scale from analytical to prep while maintaining robustness and predictable performance
Achieve high purity and recovery for greater efficiency
Choose from a wide range of sizes and chemistries to meet unique scale and molecule requirements

Informatics Solutions

Waters’ Informatics solutions provide a powerful suite of solutions for instrument control, scientific data management, network integration, and compliance management:

Maximize daily laboratory operations with OpenLynx Open Access software and efficiently manage data with Nugenesis Lab Management System
Waters’ FractionLynx Application Manager, coupled with OpenLynx, manages and automates the purification process with walk-up access, allowing labs to easily perform purifications
ChromScope Software for use on Waters purification systems enables fully automated instrument control, development of methods, and purification of samples. Effortless integration with the ACQUITY QDa Detector is now possible, providing analytical confidence from the selectivity that mass detection brings to analysis

Instrument Services

Waters’ FlexCHOICE: mySystem Coverage helps ensure high laboratory productivity and uptime, along with top system peak performance, all while considering a lab’s budget realities.

Financing

Waters Capital enables immediate access to the latest medicinal chemistry technology with flexible financing solutions and affordable payment plans. Upgrading a lab’s efficiency has never been easier through a partnership with Waters Capital. Good news for the laboratory, its bottom line, and discovery success.

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