Vion IMS QTof Ion Mobility Quadrupole Time-of-flight Mass Spectrometry

Beyond Resolution

Do you have the vision to see what others don’t see? The risk of not seeing everything in your sample – or not seeing everything clearly - can be high, especially if this results in incorrect identifications or time-consuming additional confirmatory experiments. Vion IMS QTof dramatically reduces this risk as it has the sensitivity and dynamic range to make ion mobility quantitative and routinely usable, enabling you to:

Reduce the risk of missed metabolites in DMPK analyses
Overcome complex and complicated matrices in food analysis
Generate high-quality peptide mapping data for Biopharma

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Reduce the risk of missed metabolites in DMPK Analyses

The integrated ion mobility capabilities of the Vion IMS QTof provide enhanced separation power, which delivers clearer data and greatly reduces the possibility of missing drug metabolites. Using ion mobility-enabled data independent acquisitions, Vion provides MS/MS quality product ion spectra and removes the need for additional MS/MS or data dependent acquisitions (DDA). This reduces analysis time and allows rapid identification of metabolites. The collisional cross section (CCS) values generated from Ion Mobility Separation (IMS) data can be used to track and confirm metabolites throughout discovery and development and are particularly valuable for isomeric metabolites that cannot be distinguished by chromatography. These capabilities coupled with the metabolite ID workflows within UNIFI software are designed to simplify and accelerate the acquisition and interpretation of metabolism data. Discover more.

Overcome matrix complexity and increase confidence in food analysis

Due to the orthogonal nature of ion mobility separation, Vion IMS QTof can often resolve coeluting compounds and allow the detection of components that may have been hidden by the matrix or show isomeric species that could not be separated by chromatography or mass. In addition, collisional cross section (CCS) values, which are generated automatically for each component detected by Vion, can be used for confident confirmation of contaminants or metabolites by comparison with a database and avoid false identification. The clarity of the data together with fragment ion spectra generated by Vion’s data independent acquisition (DIA) mode provides high quality information-rich data that can be utilized by workflow-based software (UNIFI) to allow confident confirmation or elucidation of compound identity. Discover more.

Generate high-quality peptide mapping data

Vion IMS QTof MS provides enhanced sensitivity, selectivity, and greater structural insight for intact protein characterization and comparability. Specificity of peptide mapping and confidence in peptide assignment is increased through the orthogonal separation provided by ion mobility. Vion IMS QTof provides automated and robust collisional cross section (CCS) measurements for every peptide. These can be automatically stored within UNIFI's Scientific Library and used for targeted peptide monitoring all within a single platform. Improved selectivity allows separation of isomeric species while significantly improved separation peak capacity enables fast peptide mapping without compromising sequence coverage. Discover more.

Get to the correct answer faster

Natural products research provides significant analytical challenges due to the complexity of the samples and the level of isomerism of the compounds of interest. The high degree of specificity afforded by combing Ultra Performance Liquid Chromatography (UPLC), time-of-flight MS and ion mobility delivers clearer and more comprehensive data. When combined with the advanced elucidation and database searching capabilities of the UNIFI software platform this allows researchers to mine a greater level of information and to get to the correct answer faster. Discover more.

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Vion IMS QTof Brochure

DMPK and Bioanalysis Knowledge Center

CCS Whitepaper

Application Note: Investigation and Performance Evaluation of a Research Prototype Tool for CCS Prediction

With its ease-of-use, flexibility and speed, CCS prediction is a highly useful tool to provide reference and guidance for qualitative analysis.
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Want to know more about the fundamentals of IMS?

Check out our new educational video that explains what ion mobility mass spec is and the benefits of collision cross section data.
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Measuring Protein Shape and Topology with Mass Spectrometry

Vicki Wysocki, professor of Chemistry and Biochemistry at Ohio State University, describes how she uses ion mobility MS to revolutionize the characterization of proteins, important in target and drug discovery fields.
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#SayYEStoIMS

Learn about IMS-MS with informative blogs, inspirational videos, the latest research papers, application notes and more at the new IMS Hub.
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Making Ion Mobility Mass Spectrometry Routine Whitepaper

Whitepaper 'Making Ion Mobility Mass Spectrometry Routine' from Waters/LCGC webinar.
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