The ACQUITY UPLC H-Class PLUS System is the next evolution of UltraPerformance instrumentation, providing the high resolution of a quaternary or binary LC System.
Achieving true UPLC performance requires that system dispersion (or extra-column band spread) to be matched to the peak widths associated with narrowbore columns packed with sub-2-μm particles. While other systems might be designed for high pressure, it doesn’t mean they're designed to deliver the sharp peaks associated with UPLC performance and the ACQUITY UPLC H-Class PLUS System.
Comparison of the same method with the same column on a low-dispersion ACQUITY UPLC H-Class PLUS System versus a higher-dispersion UHPLC system.
Take your methods to the next performance level
Leverage the benefits of UPLC Technology to improve your existing HPLC methods. By scaling your methods to UPLC, your laboratory will benefit from the combination of increased resolution, sensitivity, and speed that comes with modern small particle chemistries.
Support both HPLC and UPLC methods
Need an LC platform that can run your HPLC methods today before you begin the transition to UPLC? The ACQUITY UPLC H-Class PLUS System was designed to support both HPLC and UPLC methods so that you can invest in your laboratory’s future but still support your existing methods until you're ready to deploy UPLC.
Get the versatility to discover the best set of chromatographic conditions for your sample, providing a more robust method. The flexibility of the ACQUITY UPLC H-Class PLUS Quaternary System allows you to automatically screen important method parameters, including:
Changes in peak elution order, due to different pH conditions programmed with Auto-Blend Plus, were easily tracked with the ACQUITY QDa detector for this example of metoclopramide and its related compounds.
Combining these system capabilities with the Empower Sample Set Generator can help you to completely automate your method development experiment And with the ACQUITY QDa Detector , method development can be significantly accelerated by utilizing mass information to track the movement of peaks when evaluating different method conditions.
Deliver greater speed and precision for routine analyses
The ACQUITY UPLC H-Class PLUS Binary System combines the proven reliability and performance of the ACQUITY UPLC H-Class PLUS System with the precision and lowest system volume offered by our high-pressure mixing binary solvent manager, allowing you to:
Combine the capabilities of the ACQUITY UPLC H-Class PLUS Binary System with Waters tandem quadruple technology for routine quantitative UPLC-MS/MS applications, so you can confidently quantify and trace components in the most complex of samples.
Mass spectral data. Complete separations. Within the same analysis. Within the same workflow.
Laboratories around the world are converting to ACQUITY UPLC H-Class.
Read their stories!