Supercritical Fluid Chromatography

SFC: A Greener Approach to Analytical and Purification Applications

For laboratories overwhelmed with solvent disposal and time-consuming solvent cleanup, supercritical fluid chromatography (SFC) is a beneficial alternative to purification and analytical applications. Considered a leading "green" purification technology, SFC systems from Waters are used to separate and isolate chiral and achiral chemical compounds using various methods of detection.

The principles of SFC are similar to those of liquid chromatography, however SFC typically uses carbon dioxide as the main mobile phase. SFC is essentially a normal-phase chromatographic technique with inherent high speed and efficiency due to its mobile phase. As a high pressure liquid, or supercritical fluid, using CO2 is a smart solvent for its low viscosity and high diffusivity needed in today's demanding purification labs and also a sustainable solvent as it is reused after being discarded from other industrial processes.

SFC excels at separating and purifying chiral compounds and natural products because it's faster, uses much less solvent, and overall is a less expensive and greener method that exceeds high pressure liquid chromatography (HPLC) in performance for chiral separations.

Whether you're just looking to analyze chiral compounds or need to purify those compounds, Waters has the solution that fits your needs.

Prep SFC 150 Mgm System Prep SFC 150 Mgm System High-speed SFC purification and improved resolution of compounds, for eco friendly, higher purity isolations.
SFC 150 AP System Prep SFC 150 AP System The Prep SFC 150 AP System provides routine compound purification for drug discovery labs using MassLynx Softwarre with FractionLynx Application Manager.
SFE Bio-Botanical Extraction System The Waters Bio-Botanical Extraction System is a multi-vessel supercritical fluid extraction system ideally suited to rapidly and automatically extract large quantities of desired components from a multitude of botanical matrices.
Prep 15 SFC Purification System The Waters Prep 15 SFC System is a powerful tool that provides high-throughput, semi-preparative purification and analytical screening.
Semi-Prep SFC Investigator Investigator SFC System The Investigator SFC System offers both analytical method development and semi-preparative purification. Once the optimal mobile phase and stationary phase are determined from screening, the method can be easily scaled for purification on the same system.
Supercritical Fluid Bulk Delivery CO2 System From a common, low-pressure bulk supply or cryogenic dewar, the Bulk CO2 Delivery System (BDS 500 Gas Delivery System) enables the user to deliver high pressure CO2 flow rates without noisy pneumatic pumps.
Prep 100q SFC System Prep 100q SFC System Waters Prep 100q SFC System is the only preparative scale, open-bed supercritical fluid chromatography (SFC) system specifically designed for seamless, mass-triggered purification.
SFC Prep 80, 200, or 350 SFC 350 Preparative Systems Waters SFC 350 Preparative System for bulk-scale purification offers the optimal system for the amount of sample you need to purify. This system easily allows you to purify a large amount of one sample.
Back Pressure Regulator (BPR) The automated Back Pressure Regulator (BPR) allows for controlled depressurization of the compounds of interest and CO2 for supercritical fluids systems.
High Pressure Components Analytical 2-Prep Column Oven, high-pressure pumps, back pressure regulator (BPR), vessels, and view cells for supercritical fluid applications.
ChromScope Software ChromScope Software is for use on Waters supercritical fluid chromatography (SFC) purification systems and supercritical fluid extraction (SFE) systems. It enables fully automated instrument control, SFC methods development, and sample purification.
High-Pressure CO2 Pumps The high-pressure Pumps are ideal for high pressure, supercritical CO2 and pulseless flow applications.
SFE 500 System Prep SFE Systems Waters' Prep Supercritical Fluid Extraction (SFE) systems and extraction equipment extract chemical compounds using supercritical carbon dioxide instead of an organic solvent.

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