Information. Informatics. Impact. SYNAPT provides the most complete characterization of complex mixtures and molecules with unique levels of MS performance, industry leading informatics and unparalleled platform versatility.
Superior separation with high-efficiency T-Wave IMS
Retention. Mobility. Mass. Sometimes chromatography and mass resolution are not enough. With high-efficiency T-Wave ion mobility, you can use an additional dimension of separation, based on molecular size and shape. The unique ability to use the collision cross section property of a molecule delivers the highest levels of selectivity, specificity, sensitivity and structural insight. The wide range of benefits feature isomer separation, elimination of interferences, generation of cleaner spectra and even the ability to better confirm compound ID.
Ultimate performance for UPLC/MS/MS
Combine StepWave and UPLC separations with QuanTof, for the highest peak capacity and data quality. StepWave is the most sensitive and robust ion source available through its unique ability to 'actively' select ions and 'passively' reject neutral contaminants.
Unlike all other Tof or trap-based MS technologies, QuanTof provides; high mass resolution, accurate mass and isotope ratios, wide (in-spectrum and quantitative) dynamic range and m/z range - all together at the fastest acquisition rates, even for samples with high matrix burden.
Data independent & data dependent T-Wave IMS solutions
For profiling complex mixtures with unparalleled coverage and efficiency. The generic UPLC/HDMSE acquisition technique records fragment ion data for every detectable molecular ion with superior duty cycle to other 'data independent analysis' (DIA) techniques, while our HDMS Informatics technologies streamline data analysis for the widest range of applications.
For more efficient and effective targeted MS/MS, leverage T-Wave IMS enabled workflows. Boost your MS/MS sensitivity, for higher coverage in discovery experiments with HD-DDA (Data Directed Analysis), and lower limits of quantification using any fragments of a target molecule with HD-MRM.
CID and ETD Fragmentation Capabilities
The dual collision cell arrangement of TriWave enhances MS/MS possibilities, by providing Collision Induced Dissociation (CID) and/or Electron Transfer Dissociation (ETD) fragmentation with high resolution and accurate mass measurements. The resolving quadrupole is available in 4KDa, 8KDa or 32KDa mass range options for MS/MS of small to macromolecular species.
Waters’ ion source architecture interfaces with a huge range of techniques, from separation with UPLC, nanoUPLC, HDX Automation, APGC and UPC2 to ionisation with ESI, APCI, ASAP, DESI, DART and LDTD. They are quickly interchangeable and ready to use within minutes.
For direct analysis methods, T-Wave IMS provides the highest separation and selectivity, post-ionisation. This is particularly advantageous when combined with the high performance MALDI option, which can be rapidly switched with atmospheric pressure ion sources.
With its ease-of-use, flexibility and speed, CCS prediction is a highly useful tool to provide reference and guidance for qualitative analysis.
Vicki Wysocki, professor of Chemistry and Biochemistry at Ohio State University, describes how she uses ion mobility MS to revolutionize the characterization of proteins, important in target and drug discovery fields.