Waters Peptide and Protein Bioanalysis solutions accelerate your project timelines, increase productivity, and shorten the gap between delivery of samples to your lab and the results required to make business decisions.
We deliver a complete solution, on a familiar LC/MS/MS platform, positioning your lab to approach the quantification of peptides and proteins with confidence.
The Waters Solution:
Critical for Peptide and Protein Bioanalysis: Sample Preparation
Preparing the sample
The key to a selective methodology is through the use of Oasis SPE µelution plates. The orthogonality of Oasis particles and modifications allow a simple yet flexible method of analyte extraction. The µelution plates mean that precious analyte can easily be concentrated and labile peptides undergo the minimum of sample manipulation for high recovery and sensitivity.
Chromatographic separation of the analyte
ACQUITY UPLC Peptide Separation Technology (PST) Columns provides the pore size required for larger molecules for accurate and precise retention characteristics – sharp, narrow UPLC peaks for accurate and precise quantitation.
Detecting the analyte with MS/MS
Using the Xevo TQ-S tandem quadrupole mass spectrometer, a mass range of m/z 2000 on the first and second quadrupole allows the analyst to select the best charge state of the peptide to monitor for a high level of flexibility and simplicity of method development. IntelliStart streamlines the process by selecting the best precursor and product ions, even when the product ion has a higher m/z than the precursor ion.
Combine the market-leading sensitivity of Xevo TQ-S with the selectivity and efficiency of Oasis and ACQUITY UPLC, and developing effective methods for peptide bioanalysis is significantly simplified.