UPLC Technology, which has been adopted successfully in laboratories around the world for the most demanding separations, is highly robust, dependable, and reproducible.
The ACQUITY UPLC System eliminates significant time and cost per sample from your analytical process while improving the quality of your results. By outperforming traditional or optimized HPLC, this technology allows chromatographers to work at higher efficiencies with a much wider range of linear velocities, flow rates, and backpressures.
UPLC Technology, which has been adopted successfully in laboratories around the world for the most demanding separations, is highly robust, dependable, and reproducible. What differentiates the holistic design of ACQUITY UPLC systems is Waters’ patented sub-2-μm hybrid particle chemistry, which offers significant benefits over today's HPLC systems equipped with standard 5-μm particle chemistries.
The ACQUITY UPLC System, used on its own or paired with Waters optical and MS detection technologies, provides unique end-to-end solutions for all industries and applications, including: ADME screening, food safety, bioanalysis, clinical, metabolite identification, metabonomics, method development, opens access, and routine quality screens.
Since its invention, ACQUITY UPLC Technology has enabled analytical chemists to reach far beyond conventional HPLC separations.
Read on to discover other ACQUITY UPLC systems optimized for your specific applications, or skip down to see the features of the ACQUITY UPLC System.
ACQUITY UPLC H-Class SystemFor performing routine analyses or developing methods. Whether you are performing routine analyses or developing methods, or just prefer the flexibility of multi-solvent capabilities in a quaternary-based system, the ACQUITY UPLC H-Class System is a streamlined system that brings together the flexibility and simplicity of quaternary solvent blending and a flow-through-needle injector to deliver the advanced performance expected of UPLC type separations – high resolution, sensitivity, and improved throughput – while maintaining the robustness and reliability that ACQUITY UPLC systems are known for. |
ACQUITY UPLC I-Class SystemSolve your most complex challenges. The ACQUITY UPLC I-Class System provides the most powerful solution to the most critical need in separation science today – successfully analyzing compounds that are limited in amount or availability amid a complex matrix, more rapidly than ever before. Developed to produce the most accurate and reproducible separations, you will get the most information possible and accelerate laboratory results. |
ACQUITY UPLC M-Class SystemFor nano- to microscale separations. The ACQUITY UPLC M-Class System is the system of choice for the highest quality nano- to microscale UPLC separations, for every laboratory performing sample-limited LC/MS analyses. With unprecedented usability in a nano- to microscale platform, the ACQUITY UPLC M-Class System enables laboratories to succeed in analyzing compounds that are severely limited in amount or availability, even amid a complex matrix over several orders of magnitude.
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Efficiency gains with sub-2 μm particles:
Better information gained when analyzing more samples per unit time:
Detect compounds at increasingly lower levels without inherent changes to the detection mode, either optical or MS:
How do chromatographic technologies compare?
Waters' cutting-edge UltraPerformance LC® technology, based on known chromatographic principles, outperforms HPLC in every respect.
HPLC Resolution
Optimized HPLC separation of acetaminophen, caffeine, 7-hydroxycoumarin and coumarin, USP resolution determined from acetaminophen and caffeine peaks.
UPLC Resolution
The ACQUITY UPLC System provides more resolution, while maintaining throughput.
The ACQUITY UPLC System provides increased throughput and sensitivity, while maintaining resolution.
HPLC Speed and Sensitivity
Optimized HPLC separation of acetaminophen, caffeine, 7-hydroxycoumarin and coumarin, USP resolution determined from acetaminophen and caffeine peaks.
UPLC Speed and Sensitivity
ACQUITY UPLC provides increased throughput and sensitivity, while maintaining resolution.
The ACQUITY UPLC System provides more resolution and sensitivity, while increasing throughput with optional elevated temperatures.
HPLC Resolution, Speed, and Sensitivity
Optimized HPLC separation of acetaminophen, caffeine, 7-hydroxycoumarin and coumarin, USP resolution determined from acetaminophen and caffeine peaks.
UPLC Resolution, Speed, and Sensitivity
ACQUITY UPLC provides more resolution and sensitivity, while increasing throughput with optional elevated temperatures.