Medicinal Chemistry

The objective in medicinal chemistry is to discover the compounds that offer the most potential as pharmaceutical products, and to move the most promising into the journey of the molecule towards commercialization. Confidently confirming the identity and quality of these new chemical entities is a major challenge, particularly when labs are asked to maximize throughput and efficiency, and to manage the increasing volumes of data generated.

Medicinal chemistry is also an iterative process that demands rapid turnaround times. High throughput chromatography and mass spectrometry, together with advanced data-handling software, has high standards to meet for drug discovery compound screening, identification, optimization, and physicochemical property profiling.

Waters' UPLC and UPC2 technologies offer a sea change in capacity for medicinal chemistry laboratories.

Supercritical CO2 Based Technologies (SFx) Supercritical CO2 based technologies reduce costs and increase efficiency when applied to diverse sample types with the widest selectivities from polar to non-polar. The SFx Portfolio offers a range of supercritical CO2 based technologies:
Open Architecture UPLC Robust UPLC analyses in a familiar workflow for chemists in discovery laboratories are available with the Open Architecture UPLC System’s flat-bed sample manager and open-access software.
Compound Library Screening High-throughput compound library confirmation and purity screening is straightforward with UPLC technology.
Open Access Walk-up open access systems enable chemists in drug discovery to analyze their own samples with easy-to-use software and UPLC or UPLC/MS.
Purification/SFC/SFE Systems From HPLC to the newest Supercritical Fluid Chromatography (SFC) innovations, Waters purification systems are designed to grow and adapt to your needs.