Creating new molecules is at the very core of new drug discovery. All the knowledge and reverse engineering that went into the conception of your molecule gets proven or disproven during synthesis. Once you make the correct compound and before the sample goes for testing, you isolate it to meet purity acceptance standards.
The right combination of columns, instruments, and informatics to support the synthesis and purification your molecule helps you accelerate the drug development process. It may even reduce your time to market. Testing a drug candidate in error or with low quality could mean enormous amounts of time, resources, and money wasted; delaying your new therapeutic. .
Waters manufactures the most comprehensive suite of solutions to support drug synthesis and purification. We’d love to show you how we can help.
ACQUITY UPLC H-Class PLUS Quaternary System - A flexible, high-throughput LC platform. Whether you need to confirm presence (or formation) of your desired compound or monitor the progress of your reaction or troubleshoot issues, the ACQUITY UPLC H-Class PLUS System decreases the time to result, enabling you to quickly make decisions and increase throughput.
ACQUITY UPLC I-Class PLUS Binary System - More than any other LC configuration, the ACQUITY I-Class PLUS System pushes the limits of precision with the lowest dispersion on the market. The ACQUITY I-Class PLUS System is designed for scientists who require the highest speed, sensitivity, resolution, and gradient precision. The ACQUITY I-Class PLUS System provides the most precise and repeatable results whether you are monitoring the progress of your reaction or checking purity of your compounds.
ACQUITY UPLC UPC2 - Built upon convergence chromatography, with the unique ability to combine – or converge – the separation of a much wider variety of compounds with one chromatographic system, the ACQUITY UPC2 System provides the orthogonal capability to best analyze your most challenging molecules, such as chiral and achiral compounds. A holistically designed chromatographic technology, UPC2 uses compressed CO2 as the primary mobile phase to leverage the chromatographic principles and selectivity of normal-phase LC while providing the ease-of-use and method development simplicity of reversed-phase LC. It also reduces solvent consumption and hazardous waste disposal costs.
RADIAN ASAP Direct Mass Detector - Traditional methods to monitor chemical reactions include thin layer chromatography (TLC) and LC-MS. While inexpensive, TLC requires significant manual effort and does not deliver mass spectral information. LC-MS, on the other hand, requires long methods and potentially higher costs. The demand to accelerate the drug discovery and development process has never been higher. RADIAN ASAP provides synthetic chemists easy access to mass spectral data for near instantaneous assessment of reaction progress and identification of purification fractions, increasing laboratory efficiency.
Waters Fraction Manager – Analytical (WFM-A)
An add-on module to the Alliance, ACQUITY Arc, ACQUITY UPLC H-Class, and ACQUITY UPLC I-Class Systems, the Waters Fraction Manager (WFM-A) allows you to efficiently isolate and recover small amounts of material needed for additional analyses or studies.
Our preparative portfolio provides a wide range of scale and throughput to meet your unique needs. Whether you require single sample purification or need high-throughput purification solutions, we have the right systems. And, our technologies provide the added assurance of system robustness, minimizing interruptions and downtime – allowing you to focus on the science.
New to purification? Arm yourself with the right knowledge and information.
As the pioneer in reverse-phase chromatography, we built our preparative HPLC systems to be highly configurable, allowing you to seamlessly scale and adapt to your changing needs.
LC purification - As the pioneer in reverse-phase chromatography, we built our preparative HPLC systems to be highly configurable, allowing you to seamlessly scale and adapt to your changing needs.
SFC purification - Whether your goal is to reduce costs, decrease your environmental footprint, or tackle the toughest purification challenges, our preparative SFC systems meet your needs. Built upon supercritical fluid chromatography technology, they not only help you efficiently separate closely related or co-eluting compounds but also significantly reduce solvent usage, helping to minimize your costs.
ACQUITY UPLC PDA Detector - The ACQUITY UPLC Photodiode Array Detector (PDA) provides a lower dispersion flow cell, broad wavelength with 2D and 3D capable operation, unprecedented trace analyte detection and quantitation using broad spectrum optics of uncompromising linearity. The ACQUITY UPLC Photodiode Array Detector allows you to “see” your compounds during synthesis and purification.
ACQUITY QDa Mass Detector - Working in harmony with your chromatography and without the sample-specific or user adjustments typical of traditional mass spectrometers, the ACQUITY QDa Mass Detector provides the additional assurance of mass detection, allowing you to “know” your compounds.
ACQUITY UPLC Columns- The Waters ACQUITY UPLC columns offer flexibility and performance with over 200 combinations of column configurations and chemistries available. They can be purchased with a wide range of reproducible, selective column chemistries, and each lot undergoes rigorous validation testing to ensure highest consistency and reproducibility of your analyses.
Preparative (Purification) HPLC Columns - Our extensive OBD preparative column portfolio offers you a wide range of particle sizes, column dimensions, and column chemistries to meet your need of purification and scale-up needs for small molecule and large molecules. See the online Waters consumables catalog to help you choose the column chemistry that will best meet your needs.
OpenLynx - The OpenLynx Open Access Application Manager provides walk-up access, allowing you to maximize the number of chemists utilizing the same equipment OpenLynx helps non-expert users utilize advanced separations and mass spectroscopy capabilities to get the results they need to make a timely decision. With a user-friendly and intuitive interface, OpenLynx improves lab efficiency enabling chemists to spend their time making compounds not analyzing them.
FractionLynx - The FractionLynx Application Manager manages and automates your purification process. FractionLynx coupled with OpenLynx Open Access Application Manager provides walk-up access, allowing you to perform your purification with ease.
ChromScope - ChromScope Software enables fully automated instrument control, development of methods, and purification of samples.
To help you cost-effectively adopt the latest separations and mass spec technology, the FlexUP Technology Renewal Program helps you modernize your lab, improve data quality, and lower your total cost of ownership. FlexCAPITAL Lab Solutions offers an all-inclusive monthly payment plan with no capital outlay, eliminating unanticipated maintenance expenses and reducing downtime with state-of-the-art instrumentation.