DESI - MS Imaging for Biomedical Research

Molecular visualization and spatial distribution of compounds provide mechanistic insight

The spatial distribution of molecular species in a sample is crucial to gaining key insight into biological, chemical and physiological processes. Mass spectrometry imaging (MSI) with Desorption Electrospray Ionization Mass Spectrometry (DESI) produces label-free, multiplexed and objective measurement of molecular targets from complex surfaces. This direct-from-sample analytical technique provides researchers with the spatially resolved molecular information needed to quickly and objectively interpret molecular profiles and understand mechanistic insights with confidence.

DESI is a soft ionization technique performed under ambient environmental conditions and requires no sample preparation. This direct tissue analysis provides non-subjective information about biochemical distribution of molecules after just one measurement.

Key features of DESI Imaging Techniques

  • Ambient analysis technique to visualize the spatial localization and distribution of molecules
  • No sample preparation. Collect molecular information directly from tissue samples
  • Compatible with current histopathological workflows such as H&E Staining
  • Measure small molecule drugs, lipid and endogenous metabolites
  • Overview
  • Literature
  • Application Notes
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