Waters' solutions for biomarker verification and validation facilitate a smooth translation from discovery experiments to robust, high throughput, and high-sensitivity quantitative methods using tandem quadrupole or high-resolution time-of-flight MS systems. LC-MS based methods overcome many of the limitations of antibody-based techniques, such as ELISA or protein arrays, such as poor reproducibility, antibody development time, batch-to-batch reagent variability and the lack of multi-plexing capabilities. For protein biomarker validation in large sample cohort studies, scientists had to choose between nano-flow LC for high sensitivity or normal flow LC for throughput and robustness.
With the ionKey/MS system, scientists no longer have to make this choice and can now quantify low abundant protein biomarkers with high throughput and high sensitivity.
For protein biomarker studies, Waters LC-MS technologies deliver the fastest transition from discovery to targeted assays by expertly selecting proteotypic peptides for quantitative protein assays along with optimum Multiple Reaction Monitoring (MRM) parameters. By automatic integration with Skyline Informatics, targeted UPLC-MS/MS methods can be rapidly developed and implemented.
Waters' ionKey/MS System, a micro-fluidic separations device interfaced with Waters tandem quadrupole or high resolution time of flight platforms, offers unmatched performance for biomarker verification studies. With ionKey/MS, new levels of sensitivity, reproducibility and robustness is achieved at flow-rates of 1 nL/min. IonKey combines the sensitivity of microflow with a new level robustness and ease-of-use.
Key Technologies
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ionKey/MS |
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ACQUITY UPLC M-Class System |
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Xevo TQ-S micro |
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Xevo TQ-XS Triple Quadrupole Mass Spectrometry |
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Xevo G2-XS QTof |
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ProteinWorks |
Advancing Translational Research with LC-MS Innovations
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