ACQUITY Arc Bio System

Reliable operation under demanding conditions

Assays utilizing SEC, IEX and HIC modes of chromatography typically utilize high ionic strength mobile phases, often under basic or acidic conditions. The ACQUITY Arc Bio System’s flow paths are made of bio-inert materials to minimize undesirable protein interactions and maximize system robustness under salt and pH extremes. The result: a system that is ideally suited for routine, trouble-free operation with negligible carryover and maximum recovery of biomolecules for consistently high system performance.

Replicate your existing methods

Analytical laboratories can’t afford to use anything but the most reliable and robust equipment to ensure product consistency and compliance with regulatory guidelines. Analytical laboratories must also commonly transfer methods across the organization, or to contract partners, while preserving method integrity.

Upgrade your analytical laboratory with the ACQUITY Arc Bio System, a versatile, biocompatible LC system that delivers HPLC and UHPLC method compatibility at the flip of a switch. 

Streamline your method development

The bioQuaternary Solvent Manager automatically blends mobile phase combinations and gradients on demand, enabling you to achieve retention and critical resolution requirements for your analysis. Designed with bio-inert materials, the bioQuaternary Solvent Manager accommodates the range of aqueous, high ionic strength mobile phases and organic solvents used in several biopharmaceutical LC applications. 

Auto•Blend Plus Technology extends traditional quaternary solvent blending to permit gradient programming directly in units of pH and ionic strength, providing the ability to vary composition in even the smallest increments of pH (even those differing by 0.1 pH units or less).

Addressing your bioseparations workflow needs

Columns that were developed and QC tested with relevant biomolecules help ensure column-to-column consistency for applications ranging from synthetic oligonucleotide analysis to the characterization of intact mAb and IdeS digests. Our comprehensive family of column chemistries and biomolecule standards help address your bioseparation challenges. Empower 3 Chromatography Data Software makes it easier than ever to run protein samples and produce meaningful automated processed results and reports without experiencing downtime for training, re-engineering workflow, or adding new processing software to support advanced chromatographic techniques.