Targeted and Translational

Biology is massively complex. Humans have around 20,000 protein-encoding genes (1). Those translate into 20,000 to 100,000+ proteins, depending on whose metrics you use (2). Metabolite counts runs upwards of 110,000 with a host of bioactive isomers and isoforms (3). And those are just the biological components.

Then there are the interactions. Interactions between genes; Interactions between proteins; Interactions between metabolites; Interactions between proteins and genes, between proteins and metabolites, between metabolites and genes. In fact, the “interactome” is so complicated that few have tried to quantify it. And biological systems are thermodynamic systems.

There distribution rates of cells, reaction rates and equilibria, entropy. There are local cellular interactions impacted by distant signaling. Bewildering complexity.

Biomedical research community is confronted with trying to bring clarity to this complexity in order to elucidate potential therapeutic routes for various diseases.

Genomics analysis sheds some light on the potential of the system and immunoaffinity techniques provide some insight into the current state of the system but genomics, while multiplexed, measures what might be and immunoaffinity techniques, while measuring the current state, are limited in the number of analytes measured and often suffer from non-specificity. LC-MS workflows provide a complementary analytical workflow that is capable of simultaneously measuring 10s to 1000s of analytes with exceptional specificity.

Whether you are interested in measuring the spatial distribution of endogenous or exogenous compounds, profiling the entire metabolome, and/or quantifying a specific class of lipids or a metabolic pathway like the TCA cycle, Waters can empower your research with LC-MS-based solutions that are both powerful enough to answer your most rigorous questions and easy-to-use for your entire lab staff. For example, Waters has developed the Targeted Omics Method Library, an online repository of downloadable tandem quadrupole method packages that have been developed by the world’s best application scientists. Each method package includes a plug-and-play method file for a panel for analytes, an application note for the method, and a list of isotopically-labeled standards for the method analytes.

Mass Spectrometry Imaging A combination of advanced MS imaging technologies including MALDI, DESI and ion mobility, for comprehensive molecular distribution information in applications such as proteomics, metabolomics, cell and tissue biology, research pathology and histology.
Disease Focus | Cancer Whether your research involves quantitating specific pathways or profiling the metabolome of specific cancers, Waters offers accurate, precise, and reproducible measurements of tens to hundreds of analytes from a single sample.
Discovery and Visualization See our purposefully designed solutions for top-down or bottom-up analyses; targeted or untargeted studies; structural work to identify and confirm metabolites; or spatial localization of metabolites in biological tissues.
Targeted Omics Method Library TOML delivers a wide variety of targeted LC-MS/MS methods. Packages include an application note, experimental method files, and a list of stable-isotope labeled standards.
ionKey/MS The ionKey/MS System integrates the microflow UPLC separation directly into the source of the mass spectrometer with the iKey. This delivers LC-MS system performance and sensitivity that cannot be achieved any other way.
SYNAPT XS High Resolution Mass Spectrometer The SYNAPT XS mass spectrometer provides ultimate flexibility, offering greater freedom of analytical choice to support scientific creativity and technical success for any application.
Xevo G2-XS QTof Quadrupole Time-of-Flight Mass Spectrometry A benchtop QTof mass spectrometer incorporating the XS Collision Cell for enhanced sensitivity and selectivity, resulting in the highest quality, most comprehensive qualitative information together with the ultimate in quantitative performance.
SELECT SERIES Cyclic IMS The SELECT SERIES Cyclic IMS is a revolutionary ion mobility mass spectrometer that combines novel cyclic ion mobility with the latest Tof technology, enabling you to redefine the boundaries of what’s possible.
Xevo TQ-XS Triple Quadrupole Mass Spectrometry Waters’ most sensitive mass spectrometer, the Xevo TQ-XS Tandem, commonly known as Triple Quadrupole Mass Spectrometer expands the scope of ultimate sensitivity analysis, leading to unprecedented levels of reliability, reproducibility and performance.
Xevo TQ-S micro Triple Quadrupole Mass Spectrometry A robust and sensitive tandem quadrupole MS with compact design, featuring robust performance with a wide dynamic range and high rates of data acquisition.