Confirmation Analysis Solutions

High Performance Combined with Ease-of-Use and Robustness

Whether you need to confirm and quantify illicit drugs, prescription drugs, novel psychoactive substances (NPS), or drug metabolites, Waters UPLC-MS/MS systems ensure successful UPLC-MS/MS confirmation analysis in your forensic toxicology laboratory.

When coupled with the ACQUITY UPLC I-Class System, you have the option of adding the Xevo TQD for routine quantitative applications, or adding Xevo TQ-S/Xevo TQ-S micro for demanding, high sensitivity analysis. Waters is your single-vendor partner for UPLC-MS/MS systems, informatics, and chemistries to meet your specific forensic toxicology analysis needs.

Waters UPLC-MS/MS systems offer:

A one-vendor solution for integrated UPLC, tandem mass spectrometry, informatics, chemistries, and proven application expertise
Robust, reproducible high sensitivity with Xevo TQ-S micro and Xevo TQ-S mass spectrometers
Simultaneous acquisition of full scan mass spectra and product spectra with MRM data

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Application Expertise

LC-MS/MS is now the technique of choice in the many forensic toxicology laboratories for confirmatory analysis. Polar, non-volatile, and thermally labile compounds that are difficult to analyze by gas chromatography (GC) can be analyzed by LC-MS/MS with shortened analytical run times and without derivatization.

Waters tandem quadrupole technology is now used in leading toxicology laboratories across the world for the quantitative analysis of amphetamines, opoids, benzodiazepines, cannabinoids, synthetic cannabinoids, synthetic cathinones (bath salts), and many other classes of illicit drugs, sports doping compounds, prescription drugs, and new psychoactive substances.

Performance and Flexibility to Meet All Your Forensic Toxicology Application Needs

The exceptional performance of the Waters Xevo tandem quadrupole systems enables reliable trace-level quantitation even from volume-limited and challenging samples from alternate matrices such as hair, sweat, and oral fluid.

The universal source design of the Xevo systems means that you can easily adapt your system to meet different analytical challenges. Source options with the Xevo range include atmospheric pressure gas chromatography (APGC), ASAP solids probe for direct analysis of solids, and the unique ionKey microfluidic inlet for sample limited applications.

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10 synthetic cathinones are analyzed in less than 5 minutes and a mixture of 22 synthetic cannabinoids is analyzed in less than 8 minutes with excellent sensitivity over a wide dynamic range.

Synthetic Cannabinoids and Cathinones

Due to a significant increase in popularity and usage, synthetic cannabinoids and cathinones now present an evolving challenge for forensic toxicology laboratories. Common forms of these drugs—often marketed as legal highs and labeled as “Spice” or “Bath Salts”—can be successfully analyzed leveraging Waters Oasis sample extraction products, ACQUITY UPLC Columns, the ACQUITY UPLC I-Class System, and Xevo TQD. This combination of chemistries and UPLC-MS/MS instrumentation results in excellent chromatographic resolution, sensitivity, and swift analysis.

The data on this page shows the analysis of 10 synthetic cathinones in less than 5 minutes and the analysis of a mixture of 22 synthetic cannabinoids in less than 8 minutes with excellent sensitivity over a wide dynamic range.

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