- Magnetic bead-based ELISA — Automated bead pelleting and washing for bead-based immunoassays, replacing manual magnetic stands with consistent separation across all wells
- Liquid biopsy and circulating tumor DNA (ctDNA) enrichment — Bead-based capture and purification of cell-free DNA from plasma for oncology diagnostics
- Biomarker immunocapture — Magnetic bead-based target enrichment for low-abundance biomarker detection in complex biological matrices
- Pathogen and viral nucleic acid isolation — Automated extraction of viral RNA/DNA from clinical specimens for diagnostic workflows
Magnet+ Connected Device
Magnet+ Connected Device
Maximize sample purity with automated magnetic separation for reliable results
Maximize sample purity with automated magnetic separation for reliable results
The Magnet+ Connected Device is a magnetic separation system designed for laboratories performing bead-based purification of DNA, RNA, proteins, and cells that require reliable results across users and workflows.
The device supports automated workflows with the Andrew+ Pipetting System, works with Pipette+ Stand Electronic Pipette, or can be used manually, all driven by the same OneLab Software protocol for consistent performance.
Under optimized conditions, targets bind to magnetic beads while contaminants remain in solution, producing high-quality samples that help laboratories improve consistency and confidence in purification results.
Magnet+ Connected Device
Specifications
Overview
- Eliminate the need for centrifugation or vacuum manifolds, removing common bottlenecks in automated processes
- Ensure consistency across small and large volume labware with active vertical pelleting movement
- Enable seamless connectivity with OneLab Software via the embedded PC and Wi‑Fi/ethernet for intelligent, fully remote operation and tracking
- Achieve consistent bead pelleting from small PCR volumes up to 50 mL tubes
- Standardize methods and results across users and labs by running the same OneLab Software protocol manually, with Pipette+, or fully automated on Andrew+
- Choose from three formats: 96‑PCR Magnet+; Deepwell Magnet+; and 50 mL Tube Magnet+
Recommended Use: For labs conducting bead-based purification of DNA, RNA, proteins, and cells.
Magnet+ Connected Device is available in three OneLab Software-ready formats
Magnet+ Connected Device is available in three OneLab Software-ready formats
96-PCR Magnet+ Connected Device
-
For low-volume PCR clean-up and NGS library prep.
Deepwell Magnet+ Connected Device
-
For higher-volume DNA/RNA, protein and cell purification in deepwell plates.
50 mL Tube Magnet+ Connected Device
-
For larger-volume bead-based workflows with an efficient moving magnetic shelf.
Automated magnetic shelf for consistent bead capture
Magnetic bead-based extractions are a common way of separating molecules of interest from matrices. Magnet+ Connected Device uses an automated moving shelf that positions magnets close to the bottom of each well or tube during pelleting phases and moves away from the consumable for resuspension steps. This movement supports reliable bead capture and resuspension across PCR plates, deepwell plates, and tube formats, and the devices have a patent demonstrating that they do not have residual magnetic fields that would negatively impact binding and elution steps.
Scalable purification across labware types and volumes
Three Magnet+ Connected Devices are available, each designed for an optimal maximum volume of beads and sample: the 96 PCR Magnet+ device low-volume PCR clean-up and NGS library prep, the DeepWell Magnet+ Device for higher-volume DNA/RNA, protein and cell purification in deepwell plates, and the 50 mL Tube Magnet+ Device designed for larger-volume bead-based workflows with an efficient moving magnetic shelf.
Simplified workflows with connected software control
Magnet+ Connected Device requires no programming knowledge and is easy to implement using OneLab Software. Device pairing can be done through Wi‑Fi or LAN by following the software prompts. Once paired, OneLab Software automatically suggests the device during execution. In the protocol designer, selecting compatible labware triggers device use, and magnetic field steps are added through the actions menu, which creates a two‑part step for applying and removing the magnetic field. OneLab Software then calculates the best configurations and suggests manual, guided, or automated run options.
Applications
- Protein A antibody purification — Automated magnetic Protein A bead-based mAb isolation from cell culture supernatants or serum
- His-tagged recombinant protein purification — Ni-NTA magnetic bead purification of His-tag fusion proteins
- SP3 bead-based protein capture and clean-up — Single-pot solid-phase-enhanced sample preparation for proteomics using paramagnetic beads at room temperature
- Immunoprecipitation (IP) and co-IP — Magnetic Protein A/G bead-based target capture for protein–protein interaction studies
- Plasma proteomics / extracellular vesicle (EV) enrichment — Bead-based depletion and clean-up to address plasma dynamic range challenges before LC-MS
- General bead-based sample clean-up before LC-MS — Removing matrix interferences and contaminants from biological samples prior to chromatographic analysis
- Cell separation and selection — Magnetic bead-based positive or negative cell selection from mixed cell populations
- Bead resuspension and washing — Standardized, automated bead pelleting and resuspension across 96-well plates, eliminating manual variability
- Contaminant depletion — Removing host cell proteins, endotoxins, or other impurities from crude sample preparations using functionalized magnetic beads
Resources
Support
Support
What do you want to do?
What do you want to do?
Need Help?
Frequently Asked Questions
Frequently Asked Questions
What are the key benefits of Magnet+?
- Consistent Bead Capture — A patented automated moving magnetic shelf positions magnets precisely during pelleting and retracts them during resuspension — ensuring reproducible bead capture across every well and every run. No manual repositioning, no variability between analysts.
- No Residual Magnetic Field Interference — Patented design eliminates residual magnetic fields during binding and elution steps, preventing interference with bead-target interactions that can reduce yields.
- Three Formats for Scalable Purification — 96-PCR plates, deepwell plates, and 50 mL tubes — all sharing the same OneLab integration, automated shelf movement, and traceability.
- Connected Traceability — Magnetic field timing, pelleting duration, and resuspension steps are automatically recorded in the OneLab Software experiment report, supporting GxP compliance workflows.
- Eliminates Centrifugation and Vacuum Bottlenecks — Magnetic bead separation replaces centrifugation and vacuum filtration steps, removing common bottlenecks and enabling fully walkaway purification workflows.
- No Programming Required — Device pairing via Wi-Fi or LAN follows OneLab prompts. Selecting compatible labware automatically triggers Magnet+ use — OneLab calculates optimal configurations and suggests execution options.
Which Magnet+ format should I choose?
- 96-PCR Magnet+ — Optimized for skirted 96-PCR plates. Best for low-volume PCR clean-up and NGS library prep.
- Deepwell Magnet+ — Optimized for 96-well deepwell plates. Best for higher-volume DNA/RNA, protein, and cell purification.
- 50 mL Tube Magnet+ — Optimized for 50 mL conical centrifuge tubes. Best for larger-volume bead-based workflows with an efficient moving magnetic shelf.
All three formats share the same OneLab integration, automated shelf movement, and traceability capabilities.
Which lab scenarios are ideal for Magnet+?
- Compliance-driven purification workflows — Replace untracked manual magnetic stands with a connected device that logs every separation action automatically. OneLab Software provides the digital record QA teams and auditors require — pelleting duration, magnetic field timing, and resuspension steps captured without manual documentation.
- High-throughput bead-based purification — Workflows like nucleic acid extraction, antibody purification, and NGS library clean-up benefit from consistent, automated bead pelleting across all 96 wells — eliminating the variability of manual magnetic stand positioning.
- Manual-to-automation transition — Magnet+ uses the same OneLab Software protocol whether you run manually, with Pipette+, or fully automated on Andrew+. Validate your purification method at the bench today, then transfer it to an automated Andrew+ workflow tomorrow — same device, same protocol, no re-validation.
What are the traceability, compliance, and integration benefits?
Traceability & Compliance
Automated logging of every magnetic field application, pelleting duration, and resuspension step — no manual entries required
Digital protocols replace paper records with auditable electronic workflows for every separation step.
Supports GxP, GLP/GMP, and 21 CFR Part 11 compliance requirements
Separation data captured alongside pipetting data (Pipette+ / Andrew+) and temperature data (Peltier+ / Heater-Shaker+) in a single unified digital record for the entire sample preparation workflow
Software Integration
- OneLab + Empower — Links sample prep (including magnetic separation steps) to chromatography workflows with GxP-compliant audit trails
- OneLab + MassLynx — Exports sample lists and triggers LC–MS runs from purification-dependent prep.
- OneLab + waters_connect — Closes the loop from preparation to analytical result in a single traceable workflow.
These integrations ensure that purification steps are seamlessly linked to downstream analytical execution with full traceability.
What applications are ideal for Magnet+?
Nucleic Acid Purification
- Genomic DNA extraction — Automated gDNA isolation from blood, tissue, cells, soil, plants, and food using magnetic bead kits
- RNA purification — Total RNA and viral RNA/DNA isolation from human specimens
- Plasmid DNA purification — Automated miniprep and midiprep workflows
- PCR clean-up — Post-PCR purification of DNA fragments using magnetic beads
- Protein Purification
- Antibody purification — Automated Protein A magnetic bead-based antibody isolation
- His-tagged protein purification — Ni-NTA magnetic bead purification of recombinant proteins
- Cell Isolation
- Cell separation — Magnetic bead-based cell isolation and selection workflows
- NGS Library Preparation
- Library clean-up and size selection — SPRI bead-based purification in 96-well PCR plate format
Can I use Magnet+ without Andrew+ Robot?
Yes. Magnet+ connects directly to OneLab Software via Wi-Fi or Ethernet and can be used as a fully standalone connected device. Three modes of use are supported
Manual with OneLab guidance — OneLab guides the user through bead binding, washing, and elution steps; Magnet+ handles magnetic field positioning automatically
- Semi-automated with Pipette+ — Pipette+ delivers real-time pipetting instructions while Magnet+ coordinates separation steps
- Fully automated with Andrew+ — Andrew+ handles all pipetting; Magnet+ applies and removes the magnetic field automatically at each protocol step
How does Magnet+ work with other connected devices?
Magnet+ integrates with other OneLab-connected devices in multi-step workflows: [waterscorp...epoint.com], [OneLab for...mer facing | PowerPoint]
- Andrew+ Pipetting Robot — Automated pipetting for bead binding, washing, and elution
- Pipette+ — Semi-automated guided pipetting for manual bead purification
- Heater-Shaker+ — Lysis and incubation steps before magnetic separation
- Peltier+ — Temperature control for enzyme-sensitive purification steps
- Shaker+ — Gentle resuspension mixing between separation steps
How does Magnet+ connect to my network?
Magnet+ connects to OneLab Software via Wi-Fi (2.4/5 GHz dual-band) or Gigabit Ethernet. During initial setup, the device broadcasts its own Wi-Fi network for configuration. Once connected, OneLab Software automatically suggests Magnet+ during protocol design when compatible labware is selected — no dedicated software installation required.
Related
Design, execute, and track lab experiments with OneLab Software, secure cloud-based platform for protocol automation, traceability, and collaboration.
Transform manual pipetting into a fully automated, error-free liquid handling system with the Andrew+ Pipetting Robot, powered by OneLab Software.
Boost lab productivity with Pipette+ electronic pipettes and Andrew+ pipetting robot. Automate workflows using OneLab Software for fast, accurate, and traceable results.
