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Toward Redosable Gene Therapy: Engineering AAVs to Evade T‑Cells
Adeno-associated virus (AAV) vectors are widely used in gene therapy because of their ability to enable long-term transgene expression with favorable safety profiles. However, immune responses to the AAV capsid remain a major barrier, limiting treatment durability and the feasibility of repeat dosing. A recent Nature Communications study led by Dr. Ronit Mazor and colleagues…
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Two Truths and a Lie About Solid‑Core Particle Efficiency
Solid‑core (or superficially porous) particles are the foundation of solid core HPLC columns and have earned a reputation for delivering higher efficiency separations than similarly sized, fully porous particles. Chromatographers see this play out repeatedly across small- and large-molecule applications under a wide range of operating conditions. But why solid‑core particles are more efficient is...
Advancing Oligonucleotide Analysis with GTxResolve Microflow Columns with MaxPeak Premier Technology
As modern biopharma pipelines evolve toward increasingly complex modalities, such as therapeutic oligonucleotides, analytical scientists face a familiar pressure: obtain higher sensitivity from smaller samples, while reducing solvent consumption and workflow burden. Microflow liquid chromatography (LC) has emerged as a powerful strategy to meet these demands, and recent column technology innovations are pushing performance even...
Unlocking Faster, More Confident Antibody Analytics with Modern Protein A Affinity Chromatography
Biologics developers today face unprecedented pressure: tighter timelines, increasingly complex antibody formats, and a growing need for real-time process understanding. Yet many analytical workflows still rely on methods that can’t deliver the speed, sensitivity, or depth required for modern bioprocessing. That’s where advances in Protein A (ProA) affinity chromatography are making a meaningful difference, reshaping...
Why More Laboratories are Choosing Empower Subscription Bundles
For more than three decades, Waters Empower Chromatography Data System (CDS) has been the trusted foundation for chromatography data management. Empower Software enables laboratories to address regulatory requirements, deliver consistent results, and scale operations. But the pace of change in today’s scientific world is unprecedented- unlike anything labs have experienced before. Global supply chains, the...
Enzymatic Digestion: Accelerating Bioseparations with Novel Enzymes
The Role of Enzymes in LC-MS Analysis of Modern Biotherapeutics Enzymes are nature’s catalysts, enabling precise and efficient biochemical transformations. In analytical workflows, enzymatic digestion is a cornerstone technique for breaking down complex biomolecules into smaller, more manageable fragments. This process is critical for applications such as peptide mapping in protein characterization and oligonucleotide mapping...
FDA October 2025 Draft Guidance Sparks Industry Biosimilars Buzz
The FDA’s October 29, 2025 draft guidance has generated significant attention due to the implications for both developers and patients. By allowing developers to bypass comparative efficacy studies (CES) when advanced analytics are successful substitutes, the draft guidance avoids one of the most expensive steps, estimated to account for 70% of the total biosimilar development...
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