{"id":6732,"date":"2024-06-04T11:47:00","date_gmt":"2024-06-04T11:47:00","guid":{"rendered":"https:\/\/www.waters.com\/blog\/?p=6732"},"modified":"2026-01-21T11:47:21","modified_gmt":"2026-01-21T11:47:21","slug":"particle-size-analyzer-prices-101","status":"publish","type":"post","link":"https:\/\/www.waters.com\/blog\/particle-size-analyzer-prices-101\/","title":{"rendered":"Particle Size Analyzer Prices 101"},"content":{"rendered":"\n<p class=\"wp-block-paragraph\">In general,&nbsp;<a href=\"https:\/\/www.waters.com\/nextgen\/global\/products\/particle-analyzers.html\">particle size analyzer<\/a>&nbsp;prices&nbsp;can range from $35,000 to $250,000. The more an analyzer can do, the higher its price. It is also important to determine other factors that will add value to the right particle analyzer, including technology that allows tests using small samples, and that allows for particle testing earlier on in the discovery and development process.<\/p>\n\n\n<style>.wp-block-kadence-spacer.kt-block-spacer-6732_f7ba63-d3 .kt-block-spacer{height:60px;}.wp-block-kadence-spacer.kt-block-spacer-6732_f7ba63-d3 .kt-divider{border-top-width:1px;height:1px;border-top-color:#eee;width:80%;border-top-style:solid;}<\/style>\n<div class=\"wp-block-kadence-spacer aligncenter kt-block-spacer-6732_f7ba63-d3\"><div class=\"kt-block-spacer kt-block-spacer-halign-center\"><hr class=\"kt-divider\"\/><\/div><\/div>\n\n\n<style>.wp-block-kadence-advancedheading.kt-adv-heading6732_3b5597-13, .wp-block-kadence-advancedheading.kt-adv-heading6732_3b5597-13[data-kb-block=\"kb-adv-heading6732_3b5597-13\"]{font-style:normal;}.wp-block-kadence-advancedheading.kt-adv-heading6732_3b5597-13 mark.kt-highlight, .wp-block-kadence-advancedheading.kt-adv-heading6732_3b5597-13[data-kb-block=\"kb-adv-heading6732_3b5597-13\"] mark.kt-highlight{font-style:normal;color:#f76a0c;-webkit-box-decoration-break:clone;box-decoration-break:clone;padding-top:0px;padding-right:0px;padding-bottom:0px;padding-left:0px;}.wp-block-kadence-advancedheading.kt-adv-heading6732_3b5597-13 img.kb-inline-image, .wp-block-kadence-advancedheading.kt-adv-heading6732_3b5597-13[data-kb-block=\"kb-adv-heading6732_3b5597-13\"] img.kb-inline-image{width:150px;vertical-align:baseline;}<\/style>\n<h2 class=\"kt-adv-heading6732_3b5597-13 wp-block-kadence-advancedheading\" data-kb-block=\"kb-adv-heading6732_3b5597-13\">The Role of Particle Size Analyzers<\/h2>\n\n\n\n<p class=\"wp-block-paragraph\">Therapeutic proteins have proven to be effective treatments for human diseases. But immunogenicity can compromise the efficacy of these new therapies and lead to patient suffering and even death.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">Much of that immunogenicity comes from protein aggregates and particles, partially unfolded molecules that \u201ccome for the ride\u201d as part of the therapeutic protein\u2019s ensemble of molecules. In addition, exposure to air, solids, light, or changing temperatures (often parts of the pharmaceutical development process) can produce protein particles.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">It is essential for pharmaceutical manufacturers to correctly identify and quantify these particles and remove as much of them as possible. Waters and other manufacturers have developed particle analysis equipment (including the Aura Systems family of analyzers) that uses a number of techniques to characterize and measure the number and size of these particles. These instruments also help fulfill USP788 measurement requirements, as well as FDA regulations that demand that such particles be virtually eliminated from the final therapeutic product.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">Particles have been observed in three size ranges:&nbsp;<\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li>Nanoparticles (sub-micron) in solution (nanometer-sized)<\/li>\n\n\n\n<li>Subvisible particles (between 1 and 100 micrometers)<\/li>\n\n\n\n<li>Visible particles (greater than 100 \u00b5m)<\/li>\n<\/ul>\n\n\n<div class=\"wp-block-image\">\n<figure class=\"aligncenter size-full\"><img decoding=\"async\" width=\"940\" height=\"405\" src=\"https:\/\/www.waters.com\/blog\/wp-content\/uploads\/image-40.png\" alt=\"Comparison of the types of particles different systems can see, from monomer-oligomer aggregates to subvisible particles to visible particles.\" class=\"wp-image-6735\" srcset=\"https:\/\/www.waters.com\/blog\/wp-content\/uploads\/image-40.png 940w, https:\/\/www.waters.com\/blog\/wp-content\/uploads\/image-40-300x129.png 300w, https:\/\/www.waters.com\/blog\/wp-content\/uploads\/image-40-768x331.png 768w\" sizes=\"(max-width: 940px) 100vw, 940px\" \/><\/figure>\n<\/div>\n\n\n<p class=\"wp-block-paragraph\">Subvisible particles pose the greatest risk to patient safety and can provide early warning signs of product stability problems. Additionally, of the three ranges described, subvisible particles are also the most difficult to characterize when considered for patient safety.<\/p>\n\n\n<style>.wp-block-kadence-spacer.kt-block-spacer-6732_8b0fd5-40 .kt-block-spacer{height:60px;}.wp-block-kadence-spacer.kt-block-spacer-6732_8b0fd5-40 .kt-divider{border-top-width:1px;height:1px;border-top-color:#eee;width:80%;border-top-style:solid;}<\/style>\n<div class=\"wp-block-kadence-spacer aligncenter kt-block-spacer-6732_8b0fd5-40\"><div class=\"kt-block-spacer kt-block-spacer-halign-center\"><hr class=\"kt-divider\"\/><\/div><\/div>\n\n\n<style>.wp-block-kadence-advancedheading.kt-adv-heading6732_309459-90, .wp-block-kadence-advancedheading.kt-adv-heading6732_309459-90[data-kb-block=\"kb-adv-heading6732_309459-90\"]{font-style:normal;}.wp-block-kadence-advancedheading.kt-adv-heading6732_309459-90 mark.kt-highlight, .wp-block-kadence-advancedheading.kt-adv-heading6732_309459-90[data-kb-block=\"kb-adv-heading6732_309459-90\"] mark.kt-highlight{font-style:normal;color:#f76a0c;-webkit-box-decoration-break:clone;box-decoration-break:clone;padding-top:0px;padding-right:0px;padding-bottom:0px;padding-left:0px;}.wp-block-kadence-advancedheading.kt-adv-heading6732_309459-90 img.kb-inline-image, .wp-block-kadence-advancedheading.kt-adv-heading6732_309459-90[data-kb-block=\"kb-adv-heading6732_309459-90\"] img.kb-inline-image{width:150px;vertical-align:baseline;}<\/style>\n<h2 class=\"kt-adv-heading6732_309459-90 wp-block-kadence-advancedheading\" data-kb-block=\"kb-adv-heading6732_309459-90\">The Cost of Particle Size Analysis<\/h2>\n\n\n\n<p class=\"wp-block-paragraph\">Prices of particle size analyzers can vary a great deal. Much of the cost is based on what technology the analyzer is based on, its range of capabilities, and the sample size required. Waters, for example, offers four Aura Particle Analyzers, each with differing capabilities and applications. All Aura Systems detect, size, count, identify, and analyze particles, and can identify proteins. Aura Systems vary by application:<\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li><a href=\"https:\/\/www.waters.com\/nextgen\/global\/products\/particle-analyzers\/aura-plus.html\">Aura+<\/a> System; interdisciplinary biotherapeutics all-in-one system<\/li>\n\n\n\n<li><a href=\"https:\/\/www.waters.com\/nextgen\/global\/products\/particle-analyzers\/aura-cl.html\">Aura CL<\/a> System; for cell therapy, can identify cell aggregates and conduct cellular assays (e.g., cell viability), and contaminants, particulates, and impurities<\/li>\n\n\n\n<li><a href=\"https:\/\/www.waters.com\/nextgen\/global\/products\/particle-analyzers\/aura-gt.html\">Aura GT<\/a> System; for gene therapy, can identify capsid and viral vector aggregates, detect nucleic acid&nbsp; leakage (e.g., DNA) and proteins<\/li>\n\n\n\n<li><a href=\"https:\/\/www.waters.com\/nextgen\/global\/products\/particle-analyzers\/aura-ptx.html\">Aura PTx<\/a> System; for immune\/biologics (antibody and proteins) therapy, identifies polysorbate and proteins, and conducts immunoassays<\/li>\n<\/ul>\n\n\n\n<p class=\"wp-block-paragraph\">As previously mentioned, the more an analyzer can do, the higher its price will be in general. It is also important to determine other factors that will add value to the right particle analyzer, including technology that allows tests using small samples and that allows for particle testing earlier on in the discovery and development process.<\/p>\n\n\n<style>.wp-block-kadence-spacer.kt-block-spacer-6732_45ac2b-8f .kt-block-spacer{height:60px;}.wp-block-kadence-spacer.kt-block-spacer-6732_45ac2b-8f .kt-divider{border-top-width:1px;height:1px;border-top-color:#eee;width:80%;border-top-style:solid;}<\/style>\n<div class=\"wp-block-kadence-spacer aligncenter kt-block-spacer-6732_45ac2b-8f\"><div class=\"kt-block-spacer kt-block-spacer-halign-center\"><hr class=\"kt-divider\"\/><\/div><\/div>\n\n\n<style>.wp-block-kadence-advancedheading.kt-adv-heading6732_83fd13-6e, .wp-block-kadence-advancedheading.kt-adv-heading6732_83fd13-6e[data-kb-block=\"kb-adv-heading6732_83fd13-6e\"]{font-style:normal;}.wp-block-kadence-advancedheading.kt-adv-heading6732_83fd13-6e mark.kt-highlight, .wp-block-kadence-advancedheading.kt-adv-heading6732_83fd13-6e[data-kb-block=\"kb-adv-heading6732_83fd13-6e\"] mark.kt-highlight{font-style:normal;color:#f76a0c;-webkit-box-decoration-break:clone;box-decoration-break:clone;padding-top:0px;padding-right:0px;padding-bottom:0px;padding-left:0px;}.wp-block-kadence-advancedheading.kt-adv-heading6732_83fd13-6e img.kb-inline-image, .wp-block-kadence-advancedheading.kt-adv-heading6732_83fd13-6e[data-kb-block=\"kb-adv-heading6732_83fd13-6e\"] img.kb-inline-image{width:150px;vertical-align:baseline;}<\/style>\n<h2 class=\"kt-adv-heading6732_83fd13-6e wp-block-kadence-advancedheading\" data-kb-block=\"kb-adv-heading6732_83fd13-6e\">Particle Size Analyzers, Particle Counters, and General Particle Analyzers\u2014What\u2019s the Difference?<\/h2>\n\n\n<div class=\"wp-block-image\">\n<figure class=\"aligncenter size-full\"><img decoding=\"async\" width=\"940\" height=\"556\" src=\"https:\/\/www.waters.com\/blog\/wp-content\/uploads\/image-41.png\" alt=\"ID, count, and size for multiple particle types.\" class=\"wp-image-6736\" srcset=\"https:\/\/www.waters.com\/blog\/wp-content\/uploads\/image-41.png 940w, https:\/\/www.waters.com\/blog\/wp-content\/uploads\/image-41-300x177.png 300w, https:\/\/www.waters.com\/blog\/wp-content\/uploads\/image-41-768x454.png 768w\" sizes=\"(max-width: 940px) 100vw, 940px\" \/><figcaption class=\"wp-element-caption\">ID, count, and size for multiple particle types.<\/figcaption><\/figure>\n<\/div>\n\n\n<p class=\"wp-block-paragraph\">Size analyzers, counters, and general analyzers all provide some degree of insight into particles in your sample. However, each produces different results and varies in its degree of characterization. Choosing the right analyzer will depend on the data you need.&nbsp;<\/p>\n\n\n\n<p class=\"wp-block-paragraph\"><strong>Particle counters<\/strong>\u2014these instruments simply quantify the number of particles in a sample and provide a concentration in the sample. Types of counters include light microscopes or portable and even hand-held instruments. These counters can detect particles in liquid and air and on surfaces. However, traditional particle counters do not provide images of the actual particles themselves.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\"><strong>General particle analyzers<\/strong>\u2014these instruments can provide basic information on particle number, size, and shape, but generally are unable to provide identification information to understand particle composition and source.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\"><strong>Particle size analyzers\u2014<\/strong>like the&nbsp;<a href=\"https:\/\/www.waters.com\/nextgen\/global\/products\/particle-analyzers.html\">Aura Systems family of instruments<\/a>, provide several characteristics of particles including count\/concentrations and identification, but also size, shape, and other attributes. These are the most effective at determining the presence and size of subvisible particles, which present the greatest risk of reducing therapeutic stability.&nbsp;<\/p>\n\n\n<style>.wp-block-kadence-spacer.kt-block-spacer-6732_744b05-6d .kt-block-spacer{height:60px;}.wp-block-kadence-spacer.kt-block-spacer-6732_744b05-6d .kt-divider{border-top-width:1px;height:1px;border-top-color:#eee;width:80%;border-top-style:solid;}<\/style>\n<div class=\"wp-block-kadence-spacer aligncenter kt-block-spacer-6732_744b05-6d\"><div class=\"kt-block-spacer kt-block-spacer-halign-center\"><hr class=\"kt-divider\"\/><\/div><\/div>\n\n\n<style>.wp-block-kadence-advancedheading.kt-adv-heading6732_b78730-66, .wp-block-kadence-advancedheading.kt-adv-heading6732_b78730-66[data-kb-block=\"kb-adv-heading6732_b78730-66\"]{font-style:normal;}.wp-block-kadence-advancedheading.kt-adv-heading6732_b78730-66 mark.kt-highlight, .wp-block-kadence-advancedheading.kt-adv-heading6732_b78730-66[data-kb-block=\"kb-adv-heading6732_b78730-66\"] mark.kt-highlight{font-style:normal;color:#f76a0c;-webkit-box-decoration-break:clone;box-decoration-break:clone;padding-top:0px;padding-right:0px;padding-bottom:0px;padding-left:0px;}.wp-block-kadence-advancedheading.kt-adv-heading6732_b78730-66 img.kb-inline-image, .wp-block-kadence-advancedheading.kt-adv-heading6732_b78730-66[data-kb-block=\"kb-adv-heading6732_b78730-66\"] img.kb-inline-image{width:150px;vertical-align:baseline;}<\/style>\n<h2 class=\"kt-adv-heading6732_b78730-66 wp-block-kadence-advancedheading\" data-kb-block=\"kb-adv-heading6732_b78730-66\">Particle Size Analyzer Variability<\/h2>\n\n\n\n<p class=\"wp-block-paragraph\">Depending on the technology used and the sensitivity required, there is probably a size analyzer to meet your needs. Each analyzer is tailored to specific particle sizes and types:<\/p>\n\n\n\n<p class=\"wp-block-paragraph\"><a href=\"https:\/\/www.sciencedirect.com\/topics\/biochemistry-genetics-and-molecular-biology\/laser-diffraction\" target=\"_blank\" rel=\"noreferrer noopener\"><strong>Laser Diffraction<\/strong><\/a>\u2014leverage diffraction patterns produced by a laser beam when it passes through an object, ranging in size from nanometers to millimeters. The technique quickly measures a particle\u2019s geometric dimensions (from 10 nm to 2,000 \u00b5m).&nbsp;<\/p>\n\n\n\n<p class=\"wp-block-paragraph\"><a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC4147061\/\" target=\"_blank\" rel=\"noreferrer noopener\"><strong>Light Obscuration<\/strong><\/a>\u2014quantify particles greater than 10 \u00b5m and measure down to 2 \u00b5m. The analyzers pass a sample through a narrow opening in the device, measuring light obstruction caused by individual particles to determine size and concentration.&nbsp;<\/p>\n\n\n\n<p class=\"wp-block-paragraph\"><a href=\"https:\/\/www.sciencedirect.com\/science\/article\/abs\/pii\/S0378517320300569\" target=\"_blank\" rel=\"noreferrer noopener\"><strong>Flow Imaging<\/strong><\/a>\u2014captures particle images in a flow cell to calculate the size, shape, count, and other attributes. These cover a size range from 1 to 400 \u00b5m.&nbsp;<\/p>\n\n\n\n<p class=\"wp-block-paragraph\"><strong>Light Microscopy<\/strong>\u2014a traditional technique that counts and characterizes subvisible particles in the size range of 0.8 to 150 \u00b5m<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">None of these techniques, however, can detect invisible particles and provide adequate protection against the contamination of therapeutic samples. Larger sample sizes, inadequate detection capabilities, and the need for multiple instruments and testing runs all increase the price of particle detection (and in turn, therapeutic development).&nbsp;<\/p>\n\n\n<style>.wp-block-kadence-spacer.kt-block-spacer-6732_d0c800-0e .kt-block-spacer{height:60px;}.wp-block-kadence-spacer.kt-block-spacer-6732_d0c800-0e .kt-divider{border-top-width:1px;height:1px;border-top-color:#eee;width:80%;border-top-style:solid;}<\/style>\n<div class=\"wp-block-kadence-spacer aligncenter kt-block-spacer-6732_d0c800-0e\"><div class=\"kt-block-spacer kt-block-spacer-halign-center\"><hr class=\"kt-divider\"\/><\/div><\/div>\n\n\n<style>.wp-block-kadence-advancedheading.kt-adv-heading6732_fdb095-c7, .wp-block-kadence-advancedheading.kt-adv-heading6732_fdb095-c7[data-kb-block=\"kb-adv-heading6732_fdb095-c7\"]{font-style:normal;}.wp-block-kadence-advancedheading.kt-adv-heading6732_fdb095-c7 mark.kt-highlight, .wp-block-kadence-advancedheading.kt-adv-heading6732_fdb095-c7[data-kb-block=\"kb-adv-heading6732_fdb095-c7\"] mark.kt-highlight{font-style:normal;color:#f76a0c;-webkit-box-decoration-break:clone;box-decoration-break:clone;padding-top:0px;padding-right:0px;padding-bottom:0px;padding-left:0px;}.wp-block-kadence-advancedheading.kt-adv-heading6732_fdb095-c7 img.kb-inline-image, .wp-block-kadence-advancedheading.kt-adv-heading6732_fdb095-c7[data-kb-block=\"kb-adv-heading6732_fdb095-c7\"] img.kb-inline-image{width:150px;vertical-align:baseline;}<\/style>\n<h2 class=\"kt-adv-heading6732_fdb095-c7 wp-block-kadence-advancedheading\" data-kb-block=\"kb-adv-heading6732_fdb095-c7\">Why Choose Waters Particle Analyzers?<\/h2>\n\n\n<div class=\"wp-block-image\">\n<figure class=\"aligncenter size-full\"><img decoding=\"async\" width=\"940\" height=\"505\" src=\"https:\/\/www.waters.com\/blog\/wp-content\/uploads\/image-42.png\" alt=\"Subvisible particle analysis with Particle Vue Software.\" class=\"wp-image-6737\" srcset=\"https:\/\/www.waters.com\/blog\/wp-content\/uploads\/image-42.png 940w, https:\/\/www.waters.com\/blog\/wp-content\/uploads\/image-42-300x161.png 300w, https:\/\/www.waters.com\/blog\/wp-content\/uploads\/image-42-768x413.png 768w\" sizes=\"(max-width: 940px) 100vw, 940px\" \/><\/figure>\n<\/div>\n\n\n<p class=\"wp-block-paragraph\">Subvisible protein particles can negatively impact clinical performance to a greater degree than other degradation-related products, such as soluble aggregates and chemically modified species of protein. The Aura Systems family of particle analyzers uses&nbsp;Backgrounded Membrane Imaging (BMI)&nbsp;and&nbsp;Fluorescence Membrane Microscopy (FMM)&nbsp;to uncover this important subvisible particle data. This data analysis step is also possible at the very beginning of your process, speeding up development and letting you make better decisions, increasing the probability of being first to market. Aura Systems can:<\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li>Detect, identify, and characterize particles not measured by dynamic light scattering or size exclusion chromatography<\/li>\n\n\n\n<li>Preserve samples, using as little as 5 \u00b5l per test<\/li>\n\n\n\n<li>Move quickly with an analysis time of 1 minute per sample<\/li>\n\n\n\n<li>Get detailed information on size, morphology, count, and distribution (not possible using other methods)<\/li>\n\n\n\n<li>Operate fluidics-free, completely eliminating apparatus errors and malfunctions<\/li>\n<\/ul>\n\n\n<style>.wp-block-kadence-spacer.kt-block-spacer-6732_9a19b1-4a .kt-block-spacer{height:60px;}.wp-block-kadence-spacer.kt-block-spacer-6732_9a19b1-4a .kt-divider{border-top-width:1px;height:1px;border-top-color:#eee;width:80%;border-top-style:solid;}<\/style>\n<div class=\"wp-block-kadence-spacer aligncenter kt-block-spacer-6732_9a19b1-4a\"><div class=\"kt-block-spacer kt-block-spacer-halign-center\"><hr class=\"kt-divider\"\/><\/div><\/div>\n\n\n<style>.wp-block-kadence-advancedheading.kt-adv-heading6732_6403ab-3c, .wp-block-kadence-advancedheading.kt-adv-heading6732_6403ab-3c[data-kb-block=\"kb-adv-heading6732_6403ab-3c\"]{font-style:normal;}.wp-block-kadence-advancedheading.kt-adv-heading6732_6403ab-3c mark.kt-highlight, .wp-block-kadence-advancedheading.kt-adv-heading6732_6403ab-3c[data-kb-block=\"kb-adv-heading6732_6403ab-3c\"] mark.kt-highlight{font-style:normal;color:#f76a0c;-webkit-box-decoration-break:clone;box-decoration-break:clone;padding-top:0px;padding-right:0px;padding-bottom:0px;padding-left:0px;}.wp-block-kadence-advancedheading.kt-adv-heading6732_6403ab-3c img.kb-inline-image, .wp-block-kadence-advancedheading.kt-adv-heading6732_6403ab-3c[data-kb-block=\"kb-adv-heading6732_6403ab-3c\"] img.kb-inline-image{width:150px;vertical-align:baseline;}<\/style>\n<h2 class=\"kt-adv-heading6732_6403ab-3c wp-block-kadence-advancedheading\" data-kb-block=\"kb-adv-heading6732_6403ab-3c\">Particle Size Analyzer Price Case Study: Example of Equipment of Investment and ROI<\/h2>\n\n\n\n<p class=\"wp-block-paragraph\">A particle size analyzer made by Company X (a competitor of Aura Systems) was recently tested for its ability to evaluate the stability of adeno-associated virus (AAV) gene therapy products. Based on flow imaging, the instrument evaluated subvisible particles (between 1-100 \u00b5m) at 37\u00b0C and 75\u00b0C.&nbsp;<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">The instrument tested was able to show an increase in particle count at 37\u00b0C, and an overall decrease in particle counts at 75\u00b0C, possibly due to denaturation of AAV at that high temperature.&nbsp;<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">While the tests showed the capability of detecting subvisible particles, the sample sizes used were quite high (0.9 ml and 0.61 ml). This is orders of magnitude higher than samples used by the Aura Systems family of particle size analyzers (5 \u00b5l per test). By using less sample, the Aura System can more efficiently provide key subvisible particle data in less time, increasing the value of investment in potential therapeutic proteins.&nbsp;<\/p>\n\n\n<style>.wp-block-kadence-spacer.kt-block-spacer-6732_2bdcc4-04 .kt-block-spacer{height:60px;}.wp-block-kadence-spacer.kt-block-spacer-6732_2bdcc4-04 .kt-divider{border-top-width:1px;height:1px;border-top-color:#eee;width:80%;border-top-style:solid;}<\/style>\n<div class=\"wp-block-kadence-spacer aligncenter kt-block-spacer-6732_2bdcc4-04\"><div class=\"kt-block-spacer kt-block-spacer-halign-center\"><hr class=\"kt-divider\"\/><\/div><\/div>\n\n\n<style>.wp-block-kadence-advancedheading.kt-adv-heading6732_1f6481-24, .wp-block-kadence-advancedheading.kt-adv-heading6732_1f6481-24[data-kb-block=\"kb-adv-heading6732_1f6481-24\"]{font-style:normal;}.wp-block-kadence-advancedheading.kt-adv-heading6732_1f6481-24 mark.kt-highlight, .wp-block-kadence-advancedheading.kt-adv-heading6732_1f6481-24[data-kb-block=\"kb-adv-heading6732_1f6481-24\"] mark.kt-highlight{font-style:normal;color:#f76a0c;-webkit-box-decoration-break:clone;box-decoration-break:clone;padding-top:0px;padding-right:0px;padding-bottom:0px;padding-left:0px;}.wp-block-kadence-advancedheading.kt-adv-heading6732_1f6481-24 img.kb-inline-image, .wp-block-kadence-advancedheading.kt-adv-heading6732_1f6481-24[data-kb-block=\"kb-adv-heading6732_1f6481-24\"] img.kb-inline-image{width:150px;vertical-align:baseline;}<\/style>\n<h2 class=\"kt-adv-heading6732_1f6481-24 wp-block-kadence-advancedheading\" data-kb-block=\"kb-adv-heading6732_1f6481-24\">Conclusion and Key Takeaways<\/h2>\n\n\n\n<p class=\"wp-block-paragraph\">Detecting subvisible particles is a crucial part of preserving the structural and functional integrity of therapeutic proteins. In addition, their removal is a requirement under USP 788 and US FDA regulations. The Aura Systems family of particle size analyzers stands ahead of other methods, due to:<\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li>More thorough detection capabilities due to\u00a0Backgrounded Membrane Imaging (BMI)\u00a0and\u00a0Fluorescence Membrane Microscopy (FMM)<\/li>\n\n\n\n<li>Detection made earlier in the discovery and development process, making key decisions easier and more efficient, and bringing products to market faster<\/li>\n\n\n\n<li>Use of much smaller sample sizes (5 \u00b5l per test) compared to other methods, and faster test times (1 minute)<\/li>\n<\/ul>\n\n\n\n<p class=\"wp-block-paragraph\"><\/p>\n","protected":false},"excerpt":{"rendered":"<p>In general,&nbsp;particle size analyzer&nbsp;prices&nbsp;can range from $35,000 to $250,000. The more an analyzer can do, the higher its price. 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