{"id":4790,"date":"2020-06-23T10:52:00","date_gmt":"2020-06-23T10:52:00","guid":{"rendered":"https:\/\/www.waters.com\/blog\/reveal-molecular-secrets-and-set-them-to-work\/"},"modified":"2022-07-28T03:14:25","modified_gmt":"2022-07-28T03:14:25","slug":"reveal-molecular-secrets-and-set-them-to-work","status":"publish","type":"post","link":"https:\/\/www.waters.com\/blog\/reveal-molecular-secrets-and-set-them-to-work\/","title":{"rendered":"Reveal Molecular Secrets \u2013 and Set Them to Work!"},"content":{"rendered":"

From fundamental research to routine analysis, Waters\u2019 latest innovations in mass spectrometry enable our customers to gain – and apply – insights across the scientific spectrum.<\/h4>\n
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The SELECT SERIES\u2122 Cyclic IMS<\/figcaption><\/figure>\n

Beginning with fundamental research where the focus is on unraveling molecular complexity, new enhancements to the SELECT SERIES\u2122 Cyclic IMS<\/a> now support a combination of fragmentation and imaging strategies with advanced ion mobility capabilities. Ion mobility separates molecules by size and shape<\/a> as well as m\/z. Cyclic IMS enables researchers to scale mobility resolution to match the complexity of their samples and performs unique IMSn<\/sup> experiments (e.g. selecting an ion by IMS, fragmenting the ion, selecting a particular fragment by IMS and repeating the process) that can reveal structural information that may never have been seen before.<\/p>\n

The combination of Electron Capture Dissociation (ECD) together with the more widely used Collision Induced Dissociation (CID), greatly enhances scientists\u2019 toolset for the analysis of complex biomolecules. ECD generally preserves the position of labile post-translational modifications and provides great sequence coverage for proteins and peptides.<\/p>\n

No less illuminating than structural characterization is knowledge about spatial localization. Following the time-honored truism that \u2018a picture paints a thousand words\u2019, molecular maps can be generated using Desorption Electrospray Ionization (DESI)<\/a> \u2013 uniquely available on Waters\u2019 mass spectrometry systems. DESI XS is applicable to a broad range of different sample and surface types. Experiments can vary from tissue imaging in biomedical research and DMPK, through screening metabolites in bacterial colonies, to identifying fingerprints of different individuals taken directly from a surface and the examination of cross-sections of natural products like roots and tubers.<\/p>\n

The new capabilities on the powerful Cyclic IMS platform contribute \u2013 through the elucidation of sequence, structure and spatial distribution – to a deeper understanding of molecular mechanisms of action.<\/p><\/blockquote>\n

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A high spatial resolution DESI-MS image of lipid species present in a sagittal mouse brain section<\/figcaption><\/figure>\n

Molecular visualization is even more comprehensive on Waters\u2019 discovery platform, the SYNAPT XS<\/a>. Using DESI XS with complementary (optional) MALDI ionization maximizes the number and type of species whose distribution can be determined.<\/p>\n

Retaining high resolution imaging on a more accessible bench-top system, the Xevo G2-XS QTof also offers DESI XS technology; it not only accurately identifies \u00a0drug metabolites , for example, it can map their distribution across a tissue surface, giving scientists another dimension of information for developing the next generation of therapeutics.<\/p>\n

For routine analysis \u2013 where a molecule\u2019s characteristics have already been determined \u2013 the Xevo TQ-XS<\/a> and TQ-S micro<\/a> come into play. As a result of a collaboration with the University of Washington\u2019s Professor of Genome Sciences, Mike MacCoss<\/a> and his colleagues<\/a>, SkyLine software is now closely integrated with Waters MassLynx.<\/p>\n

The sensitivity of the Xevo TQ series combined with the industry standard Skyline software<\/a> ensures that scientists in biomedical research or in pre-clinical bioanalysis in the pharmaceutical industry can routinely and accurately determine the quantity of their target molecules when developing peptide or protein-based therapeutics. The new MassLynx\/Skyline<\/a> interface enables a seamless workflow between the MS acquisition software and the industry standard for peptide MRM optimization, simplifying method development to help identify more specific biomarkers and accelerate the discovery and pre-clinical testing of new biotherapeutic molecules.<\/p>\n

This is just one example of how partnering with leading third-party software providers expands the utility of Waters\u2019 systems and how innovations in mass spectrometry continue to drive innovation in scientific R&D and generate insights to address tomorrow\u2019s challenges.<\/p>\n

 <\/p>\n

 <\/p>\n

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 <\/p>\n","protected":false},"excerpt":{"rendered":"

From fundamental research to routine analysis, Waters\u2019 latest innovations in mass spectrometry enable our customers to gain – and apply – insights across the scientific spectrum. Beginning with fundamental research where the focus is on unraveling molecular complexity, new enhancements to the SELECT SERIES\u2122 Cyclic IMS now support a combination of fragmentation and imaging strategies…<\/p>\n","protected":false},"author":119,"featured_media":5070,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"_seopress_titles_title":"","_seopress_titles_desc":"Waters\u2019 latest innovations in mass spectrometry enable our customers to gain and apply insights across the scientific spectrum.\u00a0","_seopress_robots_index":"","_seopress_robots_follow":"","_seopress_robots_imageindex":"","_seopress_robots_snippet":"","_seopress_robots_primary_cat":"","_seopress_robots_breadcrumbs":"","_seopress_robots_freeze_modified_date":"","_seopress_robots_custom_modified_date":"","_seopress_robots_canonical":"","_seopress_social_fb_title":"","_seopress_social_fb_desc":"","_seopress_social_fb_img":"","_seopress_social_fb_img_attachment_id":0,"_seopress_social_fb_img_width":0,"_seopress_social_fb_img_height":0,"_seopress_social_twitter_title":"","_seopress_social_twitter_desc":"","_seopress_social_twitter_img":"","_seopress_social_twitter_img_attachment_id":0,"_seopress_social_twitter_img_width":0,"_seopress_social_twitter_img_height":0,"_seopress_redirections_value":"","_seopress_redirections_enabled":"","_seopress_redirections_enabled_regex":"","_seopress_redirections_logged_status":"","_seopress_redirections_param":"","_seopress_redirections_type":0,"_seopress_analysis_target_kw":"","_seopress_news_disabled":"","_seopress_video_disabled":"","_seopress_video":[],"_seopress_pro_schemas_manual":[],"_seopress_pro_rich_snippets_disable_all":"","_seopress_pro_rich_snippets_disable":[],"_seopress_pro_schemas":[],"_kad_blocks_custom_css":"","_kad_blocks_head_custom_js":"","_kad_blocks_body_custom_js":"","_kad_blocks_footer_custom_js":"","_kad_post_transparent":"","_kad_post_title":"","_kad_post_layout":"","_kad_post_sidebar_id":"","_kad_post_content_style":"","_kad_post_vertical_padding":"","_kad_post_feature":"","_kad_post_feature_position":"","_kad_post_header":false,"_kad_post_footer":false,"_kad_post_classname":"","footnotes":""},"categories":[25,22],"tags":[337,24,21],"class_list":["post-4790","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-pharmaceutical","category-technology","tag-innovation","tag-mass-spectrometry-ms","tag-research"],"acf":[],"taxonomy_info":{"category":[{"value":25,"label":"Pharmaceutical"},{"value":22,"label":"Technology"}],"post_tag":[{"value":337,"label":"innovation"},{"value":24,"label":"mass spectrometry (MS)"},{"value":21,"label":"research"}]},"featured_image_src_large":["https:\/\/www.waters.com\/blog\/wp-content\/uploads\/stock-immunoglobin-molecules-scaled-2-1024x683.jpg",1024,683,true],"author_info":{"display_name":"Ronan O'Malley","author_link":"https:\/\/www.waters.com\/blog\/author\/romalley\/"},"comment_info":"","category_info":[{"term_id":25,"name":"Pharmaceutical","slug":"pharmaceutical","term_group":0,"term_taxonomy_id":25,"taxonomy":"category","description":"We bring high-value technologies designed to solve critical, analytical problems. 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