Metabolomics and lipidomics are powerful tools in systems biology that aim to understand metabolites and lipids present in samples of biological origins. Differences in the species or amounts can be used to characterize phenotypes and biological responses to diseases, genetic modifications, or nutritional and pharmacological treatments. This information allows scientists to understand how a specific organism works, or to understand the underlying mechanism of a given disease.
Waters® state-of-the-art chromatography, ionization sources, and MS technology combined with simple, scalable, yet powerful informatics solutions provide a set of tools to unlock biological information like never before, for applications including untargeted and targeted analyses, structural elucidation, MS imaging, and ambient ionization-MS applications.
Metabolomics and lipidomics solutions from Waters deliver:
More confident identification of metabolites means more reliable interpretation of your research results and better decisions from your research.
Compound coverage and identification are critical components to any untargeted metabolomics experiment aimed at understanding the global metabolic changes that can occur in a biological system. The confidence level in identification is directly dependent on the quality of the database used. Robustly and routinely mine your complex samples with high coverage and enough statistical rigor to satisfy your most demanding research.
METLIN® MS/MS Library for Progenesis QI
Waters METLIN® MS/MS Library for Progenesis® QI offers implementation of the Waters METLIN library directly within Progenesis QI. The METLIN metabolite database, created by Prof. Gary Siuzdak, is one of the most comprehensive and widely used metabolite databases in the world today and represents the largest MS/MS collection of metabolite data generated at multiple collision energies and in positive and negative ionization modes. The Waters METLIN MS/MS library includes over 240,000 different compounds, with over 13,900 individually analyzed with measured MS/MS and over 220,000 with in silico MS/MS data.
Metabolic Profiling CCS Library
Ion mobility delivers unrivaled depth of coverage in timescales compatible with larger cohort studies to accurately quantitate biomarkers in complex backgrounds and maximize the potential success of your verification studies. The Waters Metabolic Profiling CCS Library, which includes more than 900 measurements of collision cross section (CCS) values, and more than 600 MS/MS spectra.