There's a lot of hype out there about needing ultra-high resolution for quantitative analyses.
But the reality about 140,000 is that it's a setting. It doesn't take into consideration the tradeoff in time to achieve that resolution – and that the number gets smaller with increasing m/z.
Linking mass resolution with quantitative accuracy and precision is both misleading and inaccurate.
Waters delivers high resolution time-of-flight mass spectrometers (HRMS) that, by design, have built-in compatibility with fast UPLC separations, no matter what m/z you're looking at.
Consider the molecules that are being analyzed in DMPK labs today, especially biotherapeutics. How many benefit from good chromatography and have a mass greater than 600 daltons?
As an example, how many seconds do you believe it will take your non-Tof based HRMS system to achieve 10 quantitative "ultra-high" resolution scans across peak at m/z 600 or m/z 900? Hint: At 600 m/z, it's greater than 15 seconds. And at 900 m/z, it's 24 seconds!
Shine a spotlight on what resolution and sensitivity are really all about.
Discover the truth behind HRMS analyses:
See the difference that true HRMS makes when facing the challenges of peptide bioanalysis: