When considering MS performance claims, be mindful of the small print.
For constant innovation
in DMPK, partnership
is elemental

For greater results, it's got to be Waters. To meet the global call for new, ground-breaking medicines, you need a future-focused DMPK partner who delivers industry-leading, end-to-end solutions. A laboratory technology partner who can help you drive the development of large and small molecules both in bioanalysis and metabolism studies.

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There's a lot of hype out there about needing ultra-high resolution for quantitative analyses.
But the reality about 140,000 is that it's a setting. It doesn't take into consideration the tradeoff in time to achieve that resolution – and that the number gets smaller with increasing m/z.



Linking mass resolution with quantitative accuracy and precision is both misleading and inaccurate.

  • In many workflows, resolution is a function of both transient time and m/z.
  • In electrospray ionization, sensitivity is a function of ion flux since narrow peaks are preferred.
  • Accurate quantification requires a minimum of 10 spectra across a chromatographic peak.

Waters delivers high resolution time-of-flight mass spectrometers (HRMS) that, by design, have built-in compatibility with fast UPLC separations, no matter what m/z you're looking at.

Consider the molecules that are being analyzed in DMPK labs today, especially biotherapeutics. How many benefit from good chromatography and have a mass greater than 600 daltons?

As an example, how many seconds do you believe it will take your non-Tof based HRMS system to achieve 10 quantitative "ultra-high" resolution scans across peak at m/z 600 or m/z 900? Hint: At 600 m/z, it's greater than 15 seconds. And at 900 m/z, it's 24 seconds!


Shine a spotlight on what resolution and sensitivity are really all about.

Discover the truth behind HRMS analyses:

See the difference that true HRMS makes when facing the challenges of peptide bioanalysis: