AIT Labs Reduces Costs & Improves the Quality of Results with Help from Waters UPLC/MS Technologies

Waters ACQUITY UPLC/LCT Premier Mass Spectrometry System Saves Lab Significant Time and Money for Forensic Toxicology Screenings

For Immediate Release

Milford, Massachusetts, U.S. - June 25, 2007

For a fast-paced Midwest laboratory interested in maintaining a high level of customer service and increasing profit margins, it was time to take a hard look at the tried and true analytical methods it had been using for forensic toxicology testing. So AIT Laboratories (Indianapolis, IN) turned to Waters technologies to decrease run times, reduce costs, and improve data quality.

Since AIT Laboratories converted its forensic assays to Waters UltraPerformance LC®/mass spectrometry (UPLC/MS) technology it has found that sample preparation and run times are three times faster than that of GC/MS or ELISA tests, the current industry standards. The combination of the speed and resolving power of the Waters® ACQUITY UltraPerformance LC® System coupled with the exact mass capabilities of the Waters LCT Premier™ mass spectrometer has enabled AIT to improve data quality, reduce costs, and offer nationwide clients faster turnaround.

AIT Laboratories performs work on approximately 1,200 autopsy cases per month using an ACQUITY UPLC System combined with a LCT Premier mass spectrometer for toxicology screening. The LCT Premier mass spectrometer is a time-of-flight MS system designed for routine and automated exact mass measurements for the identification of compounds. AIT has observed less ambiguity in their data with fewer false positive results, which has decreased the frequency of required confirmation testing. AIT Laboratories has also seen overall sample preparation and run times that are three times faster than that of gas chromatography/mass spectrometry (GC/MS) or immunoassay-based ELISA tests which are the standard tests most toxicology labs use today. In addition to having greater sensitivity than GC/MS, AIT's UPLC/MS system creates results that are certified in half the time it takes to certify GC/MS results. AIT estimates it is now saving more than $15,000 per month in labor and supply costs by converting to UPLC/MS.

Since it’s founding in 1990, AIT Laboratories has always relied on the use of state-of-the-art instrumentation and methodologies to meet the assay needs of clients. "At the end of the day, the benefits of the Waters technology have led to improved turn-around time for our clients, and that is what matters most," said Michael A. Evans, PhD., Founder and Chief Executive Officer of AIT Laboratories, "I'm an early adopter, and have found that keeping up with the latest technology saves time and money in the long run." AIT Laboratories recently won the 2007 TechPoint Mira Award in the health and life sciences category for its technical prowess in the realm of health and life sciences.

Before turning its toxicology screenings over to UPLC/MS, AIT Laboratories tailored an exhaustive library of hundreds of drug compounds it now uses for screening and identification purposes.

Waters ACQUITY® UPLC systems use proprietary 1.7mm chromatographic particles, very low system volumes and elevated pressure to resolve and detect more peaks in less time than conventional HPLC. When combined with the LCT Premier mass spectrometer, the system provides optimized full spectral MS detection for UPLC® separations, providing unsurpassed speed sensitivity and resolution for high throughput applications. "This technique is particularly useful for compounds which are difficult to analyze by gas chromatography-based techniques, and the simpler sample preparation requirements of LC/MS make it an invaluable tool for high-volume toxicology laboratories" said Michael Yelle, Senior Director of Clinical Operations of the Waters Division, "We are pleased to have the opportunity to work with AIT Laboratories to enable them to save costs and time while generating better data to meet exacting industry requirements."

About AIT Laboratories (www.aitlabs.com)
Renowned not only in Indiana but also nationwide, AIT was the first lab in North America to receive certification from the International Organization for Standardization (ISO), a federation of national-standards bodies concerned with consistent rules of technical specifications. The company's earned multiple honors from Indiana University's Kelley School of Business and currently ranks as a top-ten life science company in central Indiana.

The company has enjoyed a recent growth rate of three times that of the average independent lab.
AIT has also been recognized for its commitment to culture and diversity in the workplace, earning an Outstanding Employer nod from the Association for Education and Rehabilitation of the Blind and Visually Impaired and receiving a 2006 Employer Award from the Indianapolis Mayor's Office of Disability Affairs and the Mayor's Advisory Council on Disability.

AIT Laboratories' procedures comply with guidelines distributed by the Society of Forensic Toxicologists (SOFT), the American Academy of Forensic Sciences (AAFS), and The International Association of Forensic Toxicologists (TIAFT).

About Waters Corporation (www.waters.com)

Waters Corporation (NYSE:WAT) creates business advantage for laboratory-dependent organizations by delivering practical and sustainable innovation to enable significant advancements in such areas as healthcare delivery, environmental management, food safety, and water quality worldwide.

Pioneering a connected portfolio of separations science, laboratory information management, mass spectrometry and thermal analysis, supported by an expert customer services team, Waters provides an enduring platform for customer success.

With revenue of $1.28 billion in 2006 and 4,700 employees, Waters is driving scientific discovery and operational excellence for customers worldwide.

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