Literature


Description
High Sensitivity Metabolite Screening with ionKey/MS Using Post-Column Addition
Library Number: APNT134873904 | Format: PDF | File Size: 2025.58 kB | Year: 2015 | Content Type: Application Notes

Analysis of ibuprofen metabolites in urine as an example to illustrate the enhanced sensitivity obtained by using post-column addition of isopropanol.

Advancing Host Cell Protein Analyses through the Combined Use of Microscale 2D RP/RP with CSH C18 an...
Library Number: APNT134800694 | Format: PDF | File Size: 2703.89 kB | Year: 2014 | Content Type: Application Notes

Here, recent advances in microscale peptide chromatography are applied to HCP analysis.

Chromatographic Reproducibility of the Novel ionKey/MS System
Library Number: APNT134786610 | Format: PDF | File Size: 858.32 kB | Year: 2014 | Content Type: Application Notes

This technology brief evaluates the chromatographic retention time and system reproducibility of Waters® ionKey/MS™ System

Video - Managing Selectivity of Hydrophobic and Hydrophilic Compounds with HILIC and RP-LC
Library Number: APNT134790639 | Format: Web Page | File Size: - | Year: 2014 | Content Type: Application Notes

Dr. Tom Wheat discusses how to use both reversed-phase LC and HILIC modes on the ACQUITY UPLC H-Class System. He also addresses how the ACQUITY QDA Detector enables use of both UV and mass to monitor components with different responses.

Video - Using Small Modifications of pH in Chromatographic Methods Development
Library Number: APNT134790676 | Format: Web Page | File Size: - | Year: 2013 | Content Type: Application Notes

In this video, Paula Hong discusses ways to make the development of chromatographic separations more effective and more efficient by using pH and AutoBlend Plus.

Performance Verification of the USP Mometasone Furoate Ointment Method Using the Alliance HPLC Syste...
Library Number: APNT134725812 | Format: PDF | File Size: 886.22 kB | Year: 2012 | Content Type: Application Notes

This technology brief demonstrates successful performance of the USP method for mometasone furoate ointment using a robust and reliable instrument with a repeatable solvent delivery designed for analytical QC methods.

Reliable and Robust Sample Injection with the Alliance HPLC System
Library Number: APNT134725845 | Format: PDF | File Size: 1530.1 kB | Year: 2013 | Content Type: Application Notes

This technology brief demonstrates that the Alliance® HPLC System delivers linear and highly repeatable sample injections across the range of analytical HPLC injection volumes.

Impurity Profiling Using UPC2/MS
Library Number: APNT134722956 | Format: PDF | File Size: 1637.12 kB | Year: 2013 | Content Type: Application Notes

Utilizing UPC2/MS increased the knowledge base of pharmaceutical product quality, and improved the methodology procedures involved with achieving the analytical goals.

Chiral Separation of Phenylalanine Methyl Esters using UPC2
Library Number: APNT134722139 | Format: PDF | File Size: 126.89 kB | Year: 2013 | Content Type: Application Notes

A UPC2 method was developed for the chiral separation of D- and L-phenylalanine methyl esters. The method provides better resolution and 5X the throughput of normal phase HPLC, allowing for high throughput analysis.

Analysis of Tricyclic Antidepressants in Human Urine Using Convergence Chromatography (UPC2)
Library Number: APNT134721963 | Format: PDF | File Size: 1657.97 kB | Year: 2013 | Content Type: Application Notes

Charaterized by the use of an environmentally sustainable, renewable primary solvent (CO2), orthogonality to reversed phase chromatography, and availability of diverse stationary phases, UPC2 provides the benefits of reduced solvent consumption and cost, ...

Performance Verification of the USP Mometasone Furoate Ointment Method Using the Alliance HPLC Syste...
Library Number: APNT134721558 | Format: PDF | File Size: 886.22 kB | Year: 2013 | Content Type: Application Notes

This technology brief demonstrates successful performance of the USP method for mometasone furoate ointment using a robust and reliable instrument with a repeatable solvent delivery designed for analytical QC methods.

Reliable and Robust Sample Injection with the Alliance HPLC System
Library Number: APNT134721568 | Format: PDF | File Size: 1530.1 kB | Year: 2013 | Content Type: Application Notes

This technology brief demonstrates that the Alliance® HPLC System delivers linear and highly repeatable sample injections across the range of analytical HPLC injection volumes.

Chiral Separation of Clenbuterol Using UPC2
Library Number: APNT134720442 | Format: PDF | File Size: 196.89 kB | Year: 2012 | Content Type: Application Notes

Using UPC2 with smaller particle columns, a rapid method for chiral analysis of clenbuterol was developed. The analysis was completed in less than three minutes, allowing for high throughput analysis. The method was also reproducible over several injectio...

Exploring Selectivity Benefits of Fluorinated-Phenyl Stationary Phases
Library Number: APNT134716396 | Format: PDF | File Size: 2044.51 kB | Year: 2012 | Content Type: Application Notes

In this application note, column screening is facilitated with automation, using the ACQUITY UPLC H-Class System with a four-position Column Manager. Screening columns with wide selectivity ranges, understanding interactions between the analytes and stati...