Literature

This applications notebook contains application notes featuring ACQUITY Advanced Polymer Chromatography (APC) Columns authored by Waters scientists.

In this study, an automated method for efficiently and accurately measuring mycophenolic acid from plasma has been developed.

In this study, a new method for the measurement of estradiols from plasma at low levels (pmolar concentrations) has been developed.

This study develops a rapid analytical method for the simultaneous detection and quantification of 13 dyes in food products using reversed-phase chromatography with UV detection.

This technology brief describes the benefits of UltraPerformance Convergence Chromatography™ (UPC2®) as an orthogonal mode of separation to reversed-phase liquid chromatography (LC).

This application note uses peppermint extract7 to demonstrate a typical prep HPLC method development workflow, systematically improving resolution and column loading for the isolation of a minor component in a natural product.

In this study, the transfer of two USP compendial methods for impurities analysis of ziprasidone HCl from HPLC to UPLC is demonstrated.

In this study, we combine two compendial methods into one UPLC method for the separation of ziprasidone HCl impurities to reduce analysis time and improve chromatographic separation.

In this application note, we present the enantiomeric and/or diastereomeric separations of three pesticides: metalaxyl-M, S-metolachlor (acetanilide class of pesticides), and difenoconazole (a triazole fungicide).

This application note demonstrates a rapid isocratic method for the analysis of food sugars.

This technology brief demonstrate the efficacy of high resolution separations and accurate mass QTof MS for screening QuEChERS extracts of orange juice samples for pesticides at or below regulatory limits in juice samples.

This study investigates the use of both BEH C18 and CSH™ C18 columns for preparative peptide separations.

In this application note, a comparative and quantitative study of water soluble vitamins & flavonoid was carried out in fruit juices of pomegranate.

An SPE UPLC/MRM MS assay is presented for the routine high-throughput detection of more than 100 oxylipins and free fatty acids in plasma.

This application note highlights a method for the analysis of 26 opioid drugs and metabolites by mixed-mode SPE followed by UPLC®/MS/MS. Glucuronide metabolites are directly analyzed, eliminating the need for enzymatic or chemical hydrolysis. Direct compa...

This application note demonstrates how a polymer can be differentiated and characterized using Ion Mobility Spectrometry-Mass Spectrometry (IMS-MS) based on its flexibility and structure. The technique is rapid and requires very little sample preparation.

This study presents the results of screening using a method based on UPLC in combination with Tof-MSE. The use of UPLC-Tof-MSE offers unique benefits for drug screening applications due to the acquisition of an unrestricted dataset with excellent sensitiv...

In this technology brief low levels of phenylbutazone is detected and quantified in muscle tissue using ultra-sensitive UPLC-MS/MS.

This application note describes method transfer from the USP compendial method to a more modern stationary phase and subsequent analysis by UPLC is demonstrated.

In this application note ziprasidone, an anti-psychotic drug, was analyzed in both standard and capsule forms.

In this application note, a method was developed on the ACQUITY UPLC H-Class system using an ACQUITY UPLC BEH Amide sub-2 μm particle stationary phase in HILIC mode to successfully resolve and analyze metformin and six related substances.

In this study we use the USP monograph for budesonide as an example to transfer the long HPLC run to a short UPLC run.

In this study we use the USP monograph for irbesartan as an example to transfer the long HPLC run to a short UPLC run.

This application note describes USP method transfer of Lamotrigine from HPLC to UPLC.

In this study, a compendial assay method for Telmisartan Tablets written in the United States Pharmacopeia (USP)2 was transferred from HPLC to UPLC® using sub-2-μm particle technology with reduced run time and narrower peak shape for better chromatography...