Literature


Description
No Compromise! Improved Sensitivity for Negatively-Ionizing Substances
Library Number: APNT134858873 | Format: PDF | File Size: 2313.62 kB | Year: 2015 | Content Type: Application Notes

This technology brief assess the impact of alternate mobile phases on the sensitivity for a series of negatively ionizing substances.

Simplifying Methods Transfer: Novel Tools for Replicating your Established Methods on an ACQUITY Arc...
Library Number: APNT134856832 | Format: PDF | File Size: 1980.74 kB | Year: 2015 | Content Type: Application Notes

In this application note, a method transfer from another manufacturer’s HPLC System to an ACQUITY Arc system was performed using the Path 1 of the Arc Multi-flow path technology.

Influence of Sample Injection Parameters on the Performance of UltraPerformance Convergence Chromato...
Library Number: APNT134858594 | Format: PDF | File Size: 820.72 kB | Year: 2015 | Content Type: Application Notes

This technology brief demonstrates the influence of sample injection parameters on detector response and peak width for the analysis of polar analytes by UltraPerformance Convergence Chromatography™ (UPC2)/MS.

A Clinical Research Method for the Analysis of Plasma Mycophenolic Acid
Library Number: APNT134858149 | Format: PDF | File Size: 1931 kB | Year: 2015 | Content Type: Application Notes

In this application, UPLC-MS/MS method has been developed for the analysis of mycophenolic acid in human plasma for clinical research purposes.

Strategies for Improving Impurity Isolation Using Large Volume Loading and Easy Method Development i...
Library Number: APNT134858169 | Format: PDF | File Size: 2352.01 kB | Year: 2015 | Content Type: Application Notes

In this application illustrates the subsequent purification of epicatechin gallate.

Characterization of EPO N-Glycans using RapiFluor-MS and HILIC Profiling
Library Number: APNT134857872 | Format: PDF | File Size: 902.35 kB | Year: 2015 | Content Type: Application Notes

This technology brief shows how the analysis of EPO N-glycans is facilitated by the high fluorescence and MS sensitivity afforded by RapiFluor-MS labeling.

Mass-Directed Isolation of a Synthetic Peptide Using the ACQUITY QDa Detector
Library Number: APNT134857102 | Format: PDF | File Size: 2073.66 kB | Year: 2015 | Content Type: Application Notes

This application note illustrates a simple massdirected approach to peptide isolation and discuss the options for improving the efficiency of the purification protocol.

Rapidly Monitoring Released N-Glycan Profiles during Process Development Using Rapi Fluor-MS and the...
Library Number: APNT134856995 | Format: PDF | File Size: 2113.41 kB | Year: 2015 | Content Type: Application Notes

In this application note we present the use of RapiFluor-MS, a novel reagent for rapidly labeling released N-glycans.

Multi-Residue Pesticide Analysis in Dried Chili Powder: Optimized Cleanup After QuEChERS Extraction ...
Library Number: APNT134853818 | Format: PDF | File Size: 2473.13 kB | Year: 2015 | Content Type: Application Notes

This application note presents QuEChERS extraction and SPE-based cleanup strategies for multi-residue pesticide analysis of chili powder, a highly resinous and oily material obtained from dried chili pepper fruits.

Soft Drink Analysis on an ACQUITY Arc System
Library Number: APNT134856731 | Format: PDF | File Size: 2192.9 kB | Year: 2015 | Content Type: Application Notes

In this application note we describe a simple method for the QC analysis of soft drink additives.

HPLC Method Transfer for Analysis of Metoclopramide HCl and Related Substances from an Agilent 1100 ...
Library Number: APNT134856554 | Format: PDF | File Size: 1210.32 kB | Year: 2015 | Content Type: Application Notes

The goal of this technology brief is to transfer an HPLC method for related substances of metoclopramide HCl from an Agilent 1100 Series LC System to an ACQUITY® Arc™ System, replicating the chromatographic separation and meeting system suitability speci...

Eliminating Peak Distortion and Injection Solvent Effects in Chiral UPC2 Separations
Library Number: APNT134856577 | Format: PDF | File Size: 2489.84 kB | Year: 2015 | Content Type: Application Notes

This application note demonstrates the effects of solvent and analyte polarity as they relate to distorted peak profiles as well as offer general recommendations.

Multi-Residue Pesticide Analysis in Tea: Optimized Cleanup After QuEChERS Extraction for UPLC-MS/MS ...
Library Number: APNT134775094 | Format: PDF | File Size: 1711.88 kB | Year: 2015 | Content Type: Application Notes

This application note presents QuEChERS extraction and SPE-based cleanup strategies for multi-residue pesticide analysis of dried teas.

Hints and Tips for APGC coupled with Xevo TQ-S for Food and Environmental Analysis
Library Number: APNT134856240 | Format: PDF | File Size: 2631.32 kB | Year: 2015 | Content Type: Application Notes

The powerful combination of the Xevo TQ-S equipped with APGC ionization provides a robust and highly sensitive analytical solution for the analysis of food and environmental compounds at ultra-trace levels.

Indian Food Surakshaa (Safety) Application Book
Library Number: APNT134856253 | Format: PDF | File Size: 9996.31 kB | Year: 2015 | Content Type: Application Notes

Develop, extend and validate new methods for a wide range of food products and ingredients. This book includes Waters' application notes that highlight methods to address India’s current food safety (FSSAI) requirements.

Analysis of Plant Alkaloids through Accurate Mass Screening and Discovery
Library Number: APNT134856070 | Format: PDF | File Size: 2689.92 kB | Year: 2015 | Content Type: Application Notes

In this application note, the Forensic Toxicology Application Screening Solution with UNIFI1 was applied to a selection of plant alkaloids.

Analysis of Nucleotides by UltraPerformance Convergence Chromatography (UPC2)
Library Number: APNT134855713 | Format: PDF | File Size: 801.63 kB | Year: 2015 | Content Type: Application Notes

This technology brief demonstrates the advantages of utilizing UltraPerformance Convergence Chromatography™ (UPC2®) to address the analysis of highly polar compounds.

Comprehensive Characterization of the N and O-Linked Glycosylation of a Recombinant Human EPO
Library Number: APNT134855745 | Format: PDF | File Size: 2216.77 kB | Year: 2015 | Content Type: Application Notes

In this application note, we demonstrate the use of two facile strategies that can be used to detail the N and O-linked glycosylation of a recombinant, human epoetin (rhEPO).

Peptide Isolation Using the Prep 150 LC System
Library Number: APNT134854010 | Format: PDF | File Size: 1872.95 kB | Year: 2015 | Content Type: Application Notes

This application note demonstrates the analysis and UV-directed purification of a synthetic peptide using an Alliance HPLC System for screening and a Prep 150 LC System for isolation.

Prep 150 LC System: Considerations for Analytical to Preparative Scaling
Library Number: APNT134855529 | Format: PDF | File Size: 1886.44 kB | Year: 2015 | Content Type: Application Notes

In this application note, the analytical scale separation of chicken egg white is used to demonstrate the calculations and techniques used to successfully transfer from a 4.6 mm I.D. analytical column separation to a 19 mm I.D. preparatory column separati...

Techniques for Improving the Efficiency of Large Volume Loading in Preparative Liquid Chromatography
Library Number: APNT134855553 | Format: PDF | File Size: 3498.16 kB | Year: 2015 | Content Type: Application Notes

In this application note, we illustrate and compare different techniques for improving the efficiency of loading large volumes of dilute sample in weak solvent for compound isolation.

A Stress Testing Study of Glimepiride Drug Substance Utilizing UPLC/MS Methodology
Library Number: APNT10073775 | Format: PDF | File Size: 1554.88 kB | Year: 2015 | Content Type: Application Notes

In this application, a forced degradation study will be performed for the drug substance glimepiride. UPLC and the Empower 2 Software chromatography data system facilitate the analysis of the degradation behavior of drug substances during stress testing.

Utilizing UPLC/MS for Conducting Forced Degradation Studies
Library Number: 720002259EN | Format: PDF | File Size: 859.6 kB | Year: 2015 | Content Type: Application Notes

In this application note, we demonstrate the ability of an ACQUITY UPLC system combined with an ACQUITY UPLC PDA and SQ mass spectrometer to separate degradation products in simvastatin.

Rapid, Simple Impurity Characterization with the Xevo TQ MS
Library Number: APNT10093138 | Format: PDF | File Size: 2445.65 kB | Year: 2015 | Content Type: Application Notes

The rapid switching between MS and MS/MS possible with the Xevo TQ MS allows the collection of qualitative data and quantitative data in the same analytical run, with high sensitivity.

Detection and Identification of Synthetic Phosphodiesterase Type-5 Inhibitors in Adulterated Herbal ...
Library Number: APNT10119959 | Format: PDF | File Size: 2731.12 kB | Year: 2015 | Content Type: Application Notes

In this work, we evaluate the use of the Xevo TQ MS for the detection and identification of adulterants in herbal supplements.