Literature


Description
Integrating Cost-Effective Mass Detection into Oligonucleotide Analyses with the ACQUITY QDa
Library Number: APNT134934824 | Format: PDF | File Size: 510.71 kB | Year: 2017 | Content Type: Application Notes

This technology brief demonstrates that the ACQUITY QDa Detector is able to detect and report mass information for a diverse set of oligonucleotides.

A Generic Kit-Based Approach for Quantifying Monoclonal Antibody Drugs Through Direct Digestion of D...
Library Number: APNT134873397 | Format: PDF | File Size: 1336.76 kB | Year: 2016 | Content Type: Application Notes

In this application note, we have used the ProteinWorks™ eXpress Direct Digest Kit to simplify and streamline the workflow process using the same universal protocol and reagents for all monoclonal antibody drugs tested.

Rapid, Simple, and Effective Clean-up of Bovine Liver Samples Prior to UPLC-MS/MS Multiresidue Veter...
Library Number: APNT134929312 | Format: PDF | File Size: 728.94 kB | Year: 2017 | Content Type: Application Notes

This application note determines the range of veterinary drug residues in tissue samples with a single analytical method.

DESI-Mass Spectrometry Imaging Investigation of Discrete and Cassette Drug Dosed Tissues
Library Number: APNT134934269 | Format: PDF | File Size: 2108.44 kB | Year: 2017 | Content Type: Application Notes

Here we describe mass spectrometry imaging for the distribution of drugs and their associated metabolites.

LC-UV-Based Synthetic Peptide Impurity Tracking and Reporting with Compliant-Ready Empower 3 Softwar...
Library Number: APNT134934061 | Format: PDF | File Size: 605.62 kB | Year: 2017 | Content Type: Application Notes

In this work, a UPLC-UV-based method is used for determining product purity using Empower 3 Chromatography Data Software (CDS).

Absolute Quantitation of RapiFluor-MS Labeled N-Glycans by Calibration of Fluorescence Response
Library Number: APNT134932774 | Format: PDF | File Size: 571.83 kB | Year: 2017 | Content Type: Application Notes

This technology brief demonstrates the absolute quantitation of RapiFluor-MS labeled N-glycans using the RapiFluor-MS Quantitative Standard.

Screening for a Panel of 12 Toxicologically-Relevant Drugs in Urine using Tof-MRM
Library Number: APNT134933921 | Format: PDF | File Size: 818.25 kB | Year: 2017 | Content Type: Application Notes

Here we present the analysis of common drugs in urine using Tof-MRM.

Using Empower 3 Software for Monitoring Synthetic Peptide Impurities with an ACQUITY QDa Detector fo...
Library Number: APNT134933696 | Format: PDF | File Size: 391.39 kB | Year: 2017 | Content Type: Application Notes

This application note demonstrates the impurity monitoring of synthetic peptide.

Improving Routine Analysis of Insulin Analogues Using the ACQUITY QDa Detector
Library Number: APNT134933174 | Format: PDF | File Size: 280.89 kB | Year: 2017 | Content Type: Application Notes

This application note demonstrates the applicability of an LC-UV/MS workflow using the ACQUITY QDa Detector for insulin analyses.

Evaluation of Ion Mobility/Tof Mass Spectrometry with Multiple LC Method Parameters for Enhanced Det...
Library Number: APNT134933251 | Format: PDF | File Size: 1429.16 kB | Year: 2017 | Content Type: Application Notes

In this application note the metabotyping of human urine is investigated.

Discrimination of Different Unifloral Honeys Using an Untargeted High-Definition Mass Spectrometry M...
Library Number: APNT134933329 | Format: PDF | File Size: 1420.92 kB | Year: 2017 | Content Type: Application Notes

In this study we investigated whether untargeted metabolomics, using UPLC with High Definition Mass Spectrometry (HDMS) and multivariate statistics could differentiate honeys of different botanical origin.

Analysis of Cyanotoxins, Including Microcystins, in Drinking and Surface Waters by Liquid Chromatogr...
Library Number: APNT134933340 | Format: PDF | File Size: 909.66 kB | Year: 2017 | Content Type: Application Notes

This application note describes a UPLC-MS/MS method for the analysis of 10 cyanotoxins, including important microcystins, using standard addition, without the need for extraction at concentrations well below the WHO provisional guideline of 1 μg/L.

Using UPLC-MS/MS for the Determination of cTHC in Preserved Oral Fluid
Library Number: APNT134928391 | Format: PDF | File Size: 617.15 kB | Year: 2017 | Content Type: Application Notes

This technology brief describes about a simple, sensitive UPLC-MS/MS method for the determination of cTHC in oral fluid.

Adding MS Detection to the Analysis of Small Biotherapeutics Using Waters ACQUITY QDa Detector
Library Number: APNT134932751 | Format: PDF | File Size: 627.69 kB | Year: 2017 | Content Type: Application Notes

This technology brief demonstrates the applicability of the Waters ACQUITY QDa Detector in providing orthogonal mass data for a diverse sample set of small biotherapeutics.

Ion Mobility Separation Coupled With Desorption Electrospray Ionization Mass Spectrometry for High S...
Library Number: APNT134883034 | Format: PDF | File Size: 2938.11 kB | Year: 2016 | Content Type: Application Notes

This technology brief demonstrates the advantages of using ion mobility separation (IMS) in conjunction with a DESI imaging experiment on a mouse brain tissue section.

An Improved Workflow for DESI Imaging Mass Spectrometry Incorporating Waters High Definition Imaging...
Library Number: APNT134887440 | Format: PDF | File Size: 1468.41 kB | Year: 2016 | Content Type: Application Notes

This technology brief describes a new software acquisition approach which streamlines DESI imaging workflow to maximize data acquisition.

A Sensitive Microflow LC-MS/MS Method for the Analysis of Fluticasone Propionate in Human Plasma
Library Number: APNT134932133 | Format: PDF | File Size: 431.95 kB | Year: 2017 | Content Type: Application Notes

This application note demonstrates the quantification of fluticasone propionate in human plasma.

Analysis of Fingerprints by Desorption Electrospray Ionization Mass Spectrometry Imaging
Library Number: APNT134926265 | Format: PDF | File Size: 767.16 kB | Year: 2017 | Content Type: Application Notes

This technology brief demonstrates the ability of DESI-MSI to determine the gender of an individual from their fingerprint.

Increased Retention of Polar Analytes Using CORTECS T3 Columns
Library Number: APNT134930292 | Format: PDF | File Size: 293.79 kB | Year: 2017 | Content Type: Application Notes

In this application we demonstrate the increased polar retention of CORTECS T3 Columns for the isocratic separation of catechin and its metabolites.

Mass Directed SFC Purification Using ACQUITY QDa: Torus 2-PIC Separation of Goldenseal Alkaloids
Library Number: APNT134930296 | Format: PDF | File Size: 452.78 kB | Year: 2017 | Content Type: Application Notes

This application note describes the purification of natural products from herbal extracts.

Quantitative Determination of Urinary COOH-THC for Forensic Toxicology: Comparison to a Validated Re...
Library Number: APNT134919758 | Format: PDF | File Size: 221.63 kB | Year: 2016 | Content Type: Application Notes

This application note details an inter laboratory comparison of COOH-THC quantification using Oasis PRiME HLB.

Determination of Urinary Opioids by Solid-phase Extraction LC-MS/MS for Clinical Research: Compariso...
Library Number: APNT134929330 | Format: PDF | File Size: 955.55 kB | Year: 2017 | Content Type: Application Notes

The aim of this study was to compare the performance and benefits of automated sample preparation

Rapid Analysis of Pharmaceuticals in Human Tissues Using the ACQUITY UPLC with 2D Technology
Library Number: APNT134928875 | Format: PDF | File Size: 1252.55 kB | Year: 2017 | Content Type: Application Notes

This application demonstrated the automated and fast method development capability for the analysis of pharmaceuticals in human tissue samples.

The Use of PATROL UPLC Process Analysis System for Continuous Flow Chemistry Processes in a Pharmace...
Library Number: APNT134928312 | Format: PDF | File Size: 168.59 kB | Year: 2017 | Content Type: Application Notes

This work discusses the utility of UPLC based Process Analytical Technology systems for monitoring continuous flow reactions.

Peptide Optimization Using Skyline and the Xevo TQ-XS
Library Number: APNT134927635 | Format: PDF | File Size: 1980.02 kB | Year: 2017 | Content Type: Application Notes

This technology brief demonstrates the workflow for peptide MRM optimization.