Literature


Description
Optimizing HILIC-based Analyses of RapiFluor-MS Labeled Sialylated N-Glycans
Library Number: APNT134918682 | Format: PDF | File Size: 927.6 kB | Year: 2016 | Content Type: Application Notes

This application note describes applied hydrophilic interaction chromatography for the analysis of RapiFluor-MS labeled sialylated N-glycans.

High Definition Imaging (HDI) 1.4: Lock Mass Recalibration for MS Imaging Data Sets
Library Number: APNT134918626 | Format: PDF | File Size: 1293.23 kB | Year: 2016 | Content Type: Application Notes

This technology brief gives an overview on external and internal calibration for improved mass accuracy in MS imaging data sets.

ProMass for MassLynx Software for Oligonucleotide Analysis
Library Number: APNT10174847 | Format: PDF | File Size: 2601.06 kB | Year: 2010 | Content Type: Application Notes

ProMass for MassLynx Software enables batch mass deconvolution and data analysis for UPLC/MS data generated on both single quadrupole and time-of-flight Waters MS instruments. ProMass for MassLynx is the only software available on the market that performs...

UPLC-MS/MS Method for the Routine Analysis of Tobacco Specific Nitrosamines (TSNAs) in Tobacco Produ...
Library Number: APNT134918320 | Format: PDF | File Size: 225.53 kB | Year: 2016 | Content Type: Application Notes

In this technology brief, we describe an optimized UPLC-MS/MS method for TSNA analysis in tobacco products that has been developed using RADAR Technology.

Hexylammonium Acetate as an Ion-Pairing Agent for IP-RP LC Analysis of Oligonucleotides
Library Number: APNT10152270 | Format: PDF | File Size: 2122.81 kB | Year: 2010 | Content Type: Application Notes

In this application note we describe the preparation of hexylammonium acetate (HAA) and the benefits to its use for a variety of applications compared to TEAA and/or TEA-HFIP for the analysis of oligonucleotides.

UPLC Analysis of Phosphorothioate Oligonucleotides: Method Development
Library Number: APNT10014831 | Format: PDF | File Size: 1292.52 kB | Year: 2008 | Content Type: Application Notes

In this application note, we illustrate and provide guidelines for fast, high resolution, and efficient analysis of therapeutic phosphorothioate oligonucleotides in a single analysis method.

Stability of the ACQUITY UPLC System with Xevo G2-XS QTof Mass Spectrometer for Metabolic Phenotypin...
Library Number: APNT134918033 | Format: PDF | File Size: 634.17 kB | Year: 2016 | Content Type: Application Notes

This technology brief evaluates the suitability of the Waters ACQUITY UPLC System with Xevo G2-XS QTof MS for the analysis of biological fluids.

Developing a Novel, Integrated LC-MS Workflow for High-resolution Monitoring and Characterization of...
Library Number: APNT134917954 | Format: PDF | File Size: 1820.46 kB | Year: 2016 | Content Type: Application Notes

This application note describes an integrated LC-MS workflow for identification, impurity profiling, and MS/MS characterization of oligonucleotides using high-resolution mass spectrometry.

Modernization of a HILIC USP Impurity Method for Cetirizine Hydrochloride Tablets
Library Number: APNT134917789 | Format: PDF | File Size: 237.6 kB | Year: 2016 | Content Type: Application Notes

This technology brief describes the USP method for the analysis of organic impurities in cetirizine hydrochloride

Evaluation of Alternative Ion-pairing Reagents in the Analysis of Oligonucleotides with the ACQUITY ...
Library Number: APNT134917652 | Format: PDF | File Size: 776.84 kB | Year: 2016 | Content Type: Application Notes

This application note evaluates the applicability of alternative IP reagents in the analysis of oligonucleotides.

Peptide and Protein Bioanalysis Application Notebook
Library Number: APNT134830620 | Format: PDF | File Size: 19661.64 kB | Year: 2017 | Content Type: Application Notes

This application notebook details on peptide & protein bioanalysis.

Quantitative Analysis of THC and its Metabolites in Plasma Using Oasis PRiME HLB for Toxicology and ...
Library Number: APNT134916779 | Format: PDF | File Size: 334.06 kB | Year: 2016 | Content Type: Application Notes

This application note details the extraction of THC and metabolites from plasma samples using a novel SPE sorbent for forensic toxicology applications.

Identification of Skin Lightening Agents in Cosmetics Using UHPLC with PDA, Mass Detection, and Empo...
Library Number: APNT134916690 | Format: PDF | File Size: 312.55 kB | Year: 2016 | Content Type: Application Notes

In this application note, we investigated several cosmetic products that contained prohibited pharmaceutical active ingredients such as hydroquinone, corticosteroids, and tretinoin using UHPLC with PDA and mass detection.

Sensitive and Reproducible LC-MS Quantification of C-Reactive Protein in Plasma: A Potential Biomark...
Library Number: APNT134916496 | Format: PDF | File Size: 837.11 kB | Year: 2016 | Content Type: Application Notes

This application note describes a generic, kit based approach for protein quantification.

Peptide Separations Application Notebook
Library Number: APNT134916452 | Format: PDF | File Size: 67630.26 kB | Year: 2016 | Content Type: Application Notes

This document is a compilation of published LC & LC-MS applications for the analyses of peptides.

Highly Sensitive Analysis of Polar Pesticides in Food Matrices
Library Number: APNT134915753 | Format: PDF | File Size: 610.94 kB | Year: 2016 | Content Type: Application Notes

In this technology brief, we describe a sensitive LC-MS/MS method for the robust analysis of highly polar pesticides in food commodities without the need of derivatization using the Xevo TQ-XS.

Oasis PRiME HLB Cartridge for Rapid and Effective Cleanup of Avocado, a High Fat Matrix, Prior to AP...
Library Number: APNT134915055 | Format: PDF | File Size: 328.06 kB | Year: 2016 | Content Type: Application Notes

This application note demonstrates an effective cleanup protocol for pesticide analysis in avocado, a highly fatty matrix.

Analysis of Ketamine and Xylazine in Rat Tissues Using the ACQUITY UPLC with 2D Technology
Library Number: APNT134913772 | Format: PDF | File Size: 991.27 kB | Year: 2016 | Content Type: Application Notes

This application demonstrates the automated and fast method development capability of the ACQUITY UPLC with 2D Technology for the analysis of ketamine and xylazine in rat tissues.

High Definition Imaging (HDI v 1.4): “Region of Interest” Functionality
Library Number: APNT134913584 | Format: PDF | File Size: 1049.24 kB | Year: 2016 | Content Type: Application Notes

This technology brief demonstrates the improved “region of interest” (ROI) functionality within Waters® High Definition Imaging Software (HDI®) version 1.4.

The Separation of Δ8-THC, Δ9-THC, and Their Enantiomers by UPC2 Using Trefoil Chiral Columns
Library Number: APNT134913656 | Format: PDF | File Size: 789.78 kB | Year: 2016 | Content Type: Application Notes

The separation of THC and their enantiomers is determined using Acquity UPC2 system.

Dwell Volume and Extra-Column Volume: What Are They and How Do They Impact Method Transfer
Library Number: APNT134895769 | Format: PDF | File Size: 1007.76 kB | Year: 2016 | Content Type: Application Notes

The impact of dwell volume and extra-column volume on method transfer is described in this white paper.

Antioxidant Isolation Using the Prep 150 LC System
Library Number: APNT134910903 | Format: PDF | File Size: 884.99 kB | Year: 2016 | Content Type: Application Notes

This application note demonstrates the isolation and purification of chlorogenic acid from Aronia berries.

Solutions Guide for Biopharmaceuticals
Library Number: APNT134910847 | Format: PDF | File Size: 13061.24 kB | Year: 2016 | Content Type: Application Notes

Approach to the Characterization and Monitoring of Protein-based Pharmaceutical Products

Separation of Small Intact Proteins on CORTECS UPLC C8 1.6 μm Columns
Library Number: APNT134910673 | Format: PDF | File Size: 716.58 kB | Year: 2016 | Content Type: Application Notes

This technology brief demonstrates narrower peak widths observed using of CORTECS® UPLC® C8 1.6 μm Columns solid-core technology on the separation efficiency of small intact proteins.

Quantifying Primary Aromatic Amines in Polyamide Kitchenware Using the ACQUITY UPLC I-Class System a...
Library Number: APNT134909760 | Format: PDF | File Size: 556.42 kB | Year: 2016 | Content Type: Application Notes

In this application note we describe a LC-MS/MS method for the analysis of 23 common PAAs in kitchenware after migration using the ACQUITY UPLC I-Class System coupled to a Xevo TQ-S micro Mass Spectrometer.