Literature


Description
Method Transfer from Agilent 1100 Series LC System to the ACQUITY UPLC H-Class System: The Effect of...
Library Number: APNT134825276 | Format: PDF | File Size: 893.19 kB | Year: 2014 | Content Type: Application Notes

This technology brief demonstrates the comparability of temperature selectivity effects on HPLC method transfer from an Agilent 1100 Series LC System to an ACQUITY UPLC® H-Class System.

Characterizing of the Natural Product Goldenseal using Cortecs 2.7 μm Columns and ACQUITY QDa Detect...
Library Number: APNT134825070 | Format: PDF | File Size: 1720.1 kB | Year: 2014 | Content Type: Application Notes

In this application, five different sources of Goldenseal which span four different manufacturers, two different parts of the plant, and two different formulation matrices are analyzed.

The Use of HRMS and Statistical Analysis in the Investigation of Basmati Rice Authenticity and Pote...
Library Number: APNT134824425 | Format: PDF | File Size: 3085.14 kB | Year: 2014 | Content Type: Application Notes

A proof of principle method has been established to assess the authenticity of basmati rice samples with the latest advancements in high resolution GC-MS hardware and informatics.

Direct Separations of the Six Positional Isomers of Disubstituted Benzoic Acids Using ACQUITY UPC2 T...
Library Number: APNT134823326 | Format: PDF | File Size: 1733.43 kB | Year: 2014 | Content Type: Application Notes

This study illustrates the rapid and efficient separation of all six of the possible positional isomers of both the six disubstituted dimethoxybenzoic acids and also the six dimethylbenzoic acids (DMBA).

Analysis of Aldosterone in Plasma for Clinical Research using the Xevo TQ-S micro
Library Number: APNT134823344 | Format: PDF | File Size: 525.1 kB | Year: 2014 | Content Type: Application Notes

This technology brief demonstrates the capability of Waters Xevo TQ-S micro mass spectrometer, to quantify low levels of aldosterone in plasma for clinical research using a highly selective sample preparation technique.

673Direct Analysis of Opioids and Metabolites from Whole Blood Using Ostro Sample Preparation Plates...
Library Number: APNT134740601 | Format: PDF | File Size: 1632.56 kB | Year: 2014 | Content Type: Application Notes

The method presented in this study demonstrates the use of Ostro Sample Preparation Plates combined with UPLC/MS/MS for the analysis of 22 opioid compounds and metabolites of interest in whole blood samples.

0004453Rapid, Reliable Metabolite Ratio Evaluation for MIST Assessments in Drug Discovery and Precli...
Library Number: APNT134704893 | Format: PDF | File Size: 2052.3 kB | Year: 2014 | Content Type: Application Notes

To comply with U.S. FDA guidelines regarding the safety of drug metabolites in human plasma, there is a need to rapidly evaluate and accurately quantify multiple, diverse drug candidates and metabolites in a discovery or preclinical setting. Methodologie...

Improving the Cleanliness of DBS Extracts using the Ostro 96-well Sample Preparation Plate and Singl...
Library Number: APNT134632935 | Format: PDF | File Size: 1754.97 kB | Year: 2014 | Content Type: Application Notes

In this work, whole blood samples containing risperidone, its hydroxylated metabolite, 9-OH risperidone, and the internal standard, clozapine were extracted in both the traditional manner and in-well using a 96-well Ostro sample preparation plate.

Extraction of Phospholipids from Plasma using Ostro Sample Preparation
Library Number: APNT134659464 | Format: PDF | File Size: 1712.33 kB | Year: 2014 | Content Type: Application Notes

In the general protocol, the lipids are retained by the Ostro plate, and no attenpt is made to release them. Modifying the loading and elution conditions allows the same affinity to be exploited for both selective enrichment of certain classes or for tota...

Rapid Sample Preparation for Determination of PAHs in Wild-Caught Avian Eggs Utilizing QuEChERS Extr...
Library Number: APNT134771183 | Format: PDF | File Size: 1323.89 kB | Year: 2014 | Content Type: Application Notes

In this application note, a rapid, high-throughput method for the preparation of eggs for the analysis of PAHs was developed using Ostro 96-well plate technology, coupled with QuEChERS dispersive extraction.

Multiresidue LC-MS/MS Screening of Veterinary Drugs in Milk Using the Ostro Sample Preparation Plate
Library Number: APNT134805080 | Format: PDF | File Size: 1866.27 kB | Year: 2014 | Content Type: Application Notes

This application note describes the use of the Ostro Plate for multi-residue screening for veterinary drugs in milk.

Multi-Residue Pesticide Analysis in Dried Chili Powder: Optimized Cleanup After QuEChERS Extraction ...
Library Number: APNT134822313 | Format: PDF | File Size: 2504.37 kB | Year: 2014 | Content Type: Application Notes

This application note presents QuEChERS extraction and SPE-based cleanup strategies for multi-residue pesticide analysis of chili powder, a highly resinous and oily material obtained from dried chili pepper fruits.

Advantages of Ostro Pass-through Sample Preparation Versus Solid Supported Liquid Extraction (SSLE)
Library Number: APNT134822187 | Format: PDF | File Size: 1826.82 kB | Year: 2014 | Content Type: Application Notes

In this application, a comparison is performed between Ostro Pass-through Sample Preparation and SSLE.

Successful Transfer of Size-Exclusion Separations between HPLC and UPLC
Library Number: APNT134822077 | Format: PDF | File Size: 1697.49 kB | Year: 2014 | Content Type: Application Notes

This application note will highlight the considerations that must be made when transferring an SEC method between UPLC and HPLC columns and systems.

Analysis of Artificial Food Dyes Using UltraPerformance Liquid Chromatography and an Extended Wavele...
Library Number: APNT134821857 | Format: PDF | File Size: 1721.35 kB | Year: 2014 | Content Type: Application Notes

This application note presents a fast, efficient method for the analysis of food dyes in a variety of foods.

Analysis of Glyphosate, Glufosinate, and AMPA in Tap and Surface Water Using Open-Architecture UPLC ...
Library Number: APNT134821560 | Format: PDF | File Size: 1613.96 kB | Year: 2014 | Content Type: Application Notes

In this application, the analysis of glyphosate, glyfosinate, and AMPA in water was performed using three automated sequences for the derivatization and separation.

The Use of HDMS Compare Software for Comparison of Complex Polymeric Materials
Library Number: APNT134821222 | Format: PDF | File Size: 1138.06 kB | Year: 2014 | Content Type: Application Notes

In this study HDMS® Compare Software together with ion mobility mass spectrometry (IMS) has been evaluated as a comparative analytical approach to highlight and detect differences in batches of D-α-tocopheryl polyethylene glycol 1000 succinate (TPGS) pro...

Rapid Quantitative Analysis of Cannabidiol from Consumer Products
Library Number: APNT134821322 | Format: PDF | File Size: 1642.91 kB | Year: 2014 | Content Type: Application Notes

This application note will describe the rapid analysis of CBD from a several consumer products using UltraPerformance Convergence Chromatography™ (UPC2).

Quantitative Analysis of Astaxanthin in Dietary Supplements by UltraPerformance Convergence Chromato...
Library Number: APNT134820709 | Format: PDF | File Size: 1642.1 kB | Year: 2014 | Content Type: Application Notes

Quantitation of Astaxanthin was determined in this application note.

Improving the Productivity in Isolating a Naturally Occurring Bioactive Compound Using Supercritical...
Library Number: APNT134820723 | Format: PDF | File Size: 1665.45 kB | Year: 2014 | Content Type: Application Notes

In this application note, we have demonstrated employing SFE and prep SFC to holistically improve the productivity in isolating a low-polarity, bioactive compound from a complex natural product extract.

Analysis of Pharmaceuticals and Pesticides in Bottled, Tap, and Surface Water Using ACQUITY UPLC Sys...
Library Number: APNT134820733 | Format: PDF | File Size: 2654.69 kB | Year: 2014 | Content Type: Application Notes

The application targeted the analysis of PPCP’s and pesticides in bottled, tap, and surface water.

Advanced HPLC Size-Exclusion Chromatography for the Analysis of Macromolecular Proteins Using 3.5 μm...
Library Number: APNT134820571 | Format: PDF | File Size: 1814.57 kB | Year: 2014 | Content Type: Application Notes

This application note highlights the performance characteristics of both the 200Å and 450Å pore-size versions of columns, designed for the separation of macromolecular proteins, with respect to resolution, column-to-column reproducibility, and column stab...

Analysis of 2- and 4-Methylimidazole in Beverages using Alliance HPLC with Mass Detection
Library Number: APNT134820627 | Format: PDF | File Size: 1773.03 kB | Year: 2014 | Content Type: Application Notes

In this application note we show a rapid analysis (<8.5 min) for 4-MEI and its isomer, 2-MEI using HPLC separation on a Waters CORTECS Column with mass detection.

A Validated Assay for the Quantification of Amino Acids in Mammalian Urine
Library Number: APNT134820198 | Format: PDF | File Size: 1657.54 kB | Year: 2014 | Content Type: Application Notes

In this application note a robust, reliable method for the absolute quantification of twenty amino acids and the relative quantification of a further eighteen amino acids in human urine has been developed and evaluated.

Increasing Sensitivity and Minimizing Sample Volume for the Quantification of Therapeutic and Endoge...
Library Number: APNT134817596 | Format: PDF | File Size: 3250.22 kB | Year: 2014 | Content Type: Application Notes

This application investigates the improved sensitivity and decreased sample volume requirements for the therapeutic and endogenous cyclic peptides: desmopressin, vasopressin and octreotide.