Literature


Description
Use of Online SPE for Clinical Research in the Automated Analysis of Mycophenolic Acid by LC-MS
Library Number: APNT134812468 | Format: PDF | File Size: 608.33 kB | Year: 2014 | Content Type: Application Notes

This technology brief demonstrates that the use of an online SPE system (ACQUITY UPLC® Online SPE Manager) enables the automated, efficient analysis of mycophenolic acid by LC-MS for clinical research.

Complementing Routine Peptide Monitoring Using the ACQUITY QDa Mass Detector
Library Number: APNT134812229 | Format: PDF | File Size: 1585.99 kB | Year: 2014 | Content Type: Application Notes

The objective of this application is to demonstrate the use of the ACQUITY QDa Detector as a complementary orthogonal detection technique that enables the integration of optical (UV) and basic mass spectral data within a single workflow using a known pept...

Using ACQUITY UPC2® System with QTof™ for Rapid Screening of Pharmaceutical Drug Metabolites
Library Number: APNT134811758 | Format: PDF | File Size: 1242.79 kB | Year: 2014 | Content Type: Application Notes

This technology brief demonstrates the use of UltraPerformance Convergence Chromatography™ (UPC2®) with its orthogonal selectivity to UPLC® for use in drug metabolism studies.

Analyzing Multi-Class Persistent Organic Pollutants in Food Matrices with APGC-MS/MS
Library Number: APNT134811432 | Format: PDF | File Size: 1939.53 kB | Year: 2014 | Content Type: Application Notes

Validated and quantitative method for 141 multi-class POP compounds (OCPs, PCBs, PBDEs and PAHs) in a variety of foodstuffs that provides increased sensitivity and selectivity for GC amenable POPs.

Automating the Creation of Chromatographic Methods for Method Validation Using Empower Sample Set Ge...
Library Number: APNT134810962 | Format: PDF | File Size: 2122.91 kB | Year: 2014 | Content Type: Application Notes

This technology brief demonstrates the use of Empower® 3 Software’s Sample Set Generator to automate the creation of chromatographic methods and sample set methods, used in the validation of a UPLC® method for metoclopramide HCl and related substances.

Mass-Directed Isolation of a Pharmaceutical Compound Using AutoPurify with an ACQUITY QDa Detector
Library Number: APNT134810328 | Format: PDF | File Size: 2119.31 kB | Year: 2014 | Content Type: Application Notes

In this application note, we demonstrate the feasibility of successfully isolating a synthetic pharmaceutical compound from a crude mixture using AutoPurify on an AutoPurification System configured with an ACQUITY QDa Detector.

Isolation of a Natural Product from Echinacea Extract Using the Prep 150 LC
Library Number: APNT134810190 | Format: PDF | File Size: 1660.33 kB | Year: 2014 | Content Type: Application Notes

In this study, we focus on the feasibility of using the Prep 150 LC System as a tool for isolating cichoric acid from Echinacea purpurea extract.

Typical Conditions for Analyzing and Isolating the Compounds in the Preparative Chromatography Mixtu...
Library Number: APNT134809624 | Format: PDF | File Size: 1437.25 kB | Year: 2014 | Content Type: Application Notes

This technology brief provides chromatographic method conditions for preparative systems configured with an ACQUITY® QDa® Detector using the Preparative Chromatography Mix Standard as a system test prior to injecting samples for isolation.

Mass-Directed Isolation of Sulfa Compounds from an Antibiotic Mixture with an ACQUITY QDa Detector
Library Number: APNT134809643 | Format: PDF | File Size: 1251.63 kB | Year: 2014 | Content Type: Application Notes

This technology brief illustrates the utility of mass-directed purification on preparative chromatography systems configured with an ACQUITY® QDa® Detector.

The Benefits of using MALDI with Ion Mobility
Library Number: APNT134809590 | Format: PDF | File Size: 6247.54 kB | Year: 2014 | Content Type: Application Notes

This technology brief demonstrates the advantages of coupling MALDI and IMMS for polymer analysis, using copolymers as a model.

Reducing Sample Volume and Increasing Sensitivity for the Quantification of Human Insulin and 5 Anal...
Library Number: APNT134809163 | Format: PDF | File Size: 2501.06 kB | Year: 2014 | Content Type: Application Notes

In this application structures for human insulin and their analogs were quantified.

Increasing Efficiency of Method Validation for Metoclopramide HCl and Related Substances with Empowe...
Library Number: APNT134808554 | Format: PDF | File Size: 2492.32 kB | Year: 2014 | Content Type: Application Notes

We demonstrate the validation of a UPLC method for linearity, detection and quantitation limits, accuracy, repeatability, intermediate precision, specificity, and robustness using Empower 3 Method Validation Manager.

A Label-Free, Multi-Omic Study to Qualitatively and Quantitatively Characterize the Effects of a Glu...
Library Number: APNT134808146 | Format: PDF | File Size: 3974.24 kB | Year: 2014 | Content Type: Application Notes

A label-free, multi-omics approach provided qualitative and quantitative information in a single experiment to help characterize and investigate the effects of a glucosylceramide inhibitor for treatment of obesity.

Waters Environmental Application Notes Booklet
Library Number: APNT134807775 | Format: PDF | File Size: 8268.62 kB | Year: 2014 | Content Type: Application Notes

In our 2014 environmental application notes booklet, learn how Waters latest technologies are being applied to the analysis of dioxins, perfluoroalkyl and polyfluoroalkyl substances (PFAS’s), Polycyclic aromatic hydrocarbons (PAHs), pharmaceuticals and...

Future-proofing the Biopharmaceutical QC Laboratory: Using the ACQUITY UPLC H-Class Bio to Run SEC H...
Library Number: APNT134807673 | Format: PDF | File Size: 1818.76 kB | Year: 2014 | Content Type: Application Notes

To demonstrate the applicability of the ACQUITY UPLC H-Class Bio System for performing both SEC-HPLC and SEC-UPLC, we present here the transfer of an SEC-HPLC assay for monoclonal antibody aggregation from legacy HPLC instrumentation to the ACQUITY UPLC H...

Profiling Mono and Disaccharides in Juice, Wine, Beer, and Cider Using the ACQUITY UPLC H-Class Syst...
Library Number: APNT134807550 | Format: PDF | File Size: 1564.6 kB | Year: 2014 | Content Type: Application Notes

This application note a complementary detection method to Refractive Index (RI) and Evaporative Light Scattering (ELS) detectors that are commonly used for carbohydrate analysis.

Rapid and Simultaneous Analysis of Urinary Catecholamines and Metanephrines Using Mixed-Mode SPE and...
Library Number: APNT134807288 | Format: PDF | File Size: 1480.77 kB | Year: 2014 | Content Type: Application Notes

The extraction and analysis of urinary catecholamines and metanephrines using the Oasis mixed-mode weak cation exchange (WCX) plates and an ACQUITY UPLC BEH Amide

Rapid and Simultaneous Analysis of Plasma Catecholamines and Metanephrines Using Mixed-Mode SPE and ...
Library Number: APNT134807281 | Format: PDF | File Size: 1659.94 kB | Year: 2014 | Content Type: Application Notes

The extraction and analysis of plasma catecholamines and metanephrines using Oasis WCX μElution Plates and an ACQUITY UPLC BEH Amide Column in HILIC mode is detailed.

Clinical Research Method for the Fast, Efficient Analysis of Mycophenolic Acid Utilizing Online Soli...
Library Number: APNT134738817 | Format: PDF | File Size: 2257.83 kB | Year: 2014 | Content Type: Application Notes

In this study, an automated method for efficiently and accurately measuring mycophenolic acid from plasma has been developed.

Transferring HPLC Gradient Methods Using CORTECS Solid-Core Particle Columns
Library Number: APNT134806971 | Format: PDF | File Size: 1516.9 kB | Year: 2014 | Content Type: Application Notes

The following application note demonstrates a proper method transfer of a typical HPLC gradient method for abacavir-related compounds.

Forced Degradation Analysis of Omeprazole Using CORTECS 2.7 μm Columns
Library Number: APNT134806927 | Format: PDF | File Size: 1440.18 kB | Year: 2014 | Content Type: Application Notes

In this application note a forced degradation study of Omeprazole was performed using a CORTECS C18+, 2.7 μm, 4.6 x 150 mm Column on an Alliance HPLC System equipped with both a PDA and QDa Detector.

Selective and Sensitive Screening of 23 Azo Dyes Using the ACQUITY UPLC H-Class System and the ACQUI...
Library Number: APNT134806029 | Format: PDF | File Size: 631.89 kB | Year: 2014 | Content Type: Application Notes

This technology brief descrives a rapid, easy, and selective quantification method for prohibited azo dyes at 100 times below the legislative limits.

LC-MS Determination of Sudan Dyes in Chili Oleoresin Using the CORTECS C18, 2.7 μm Column
Library Number: APNT134805553 | Format: PDF | File Size: 1754.82 kB | Year: 2014 | Content Type: Application Notes

This application note presents an SPE-based analytical method suitable for the determination of common Sudan dyes in chili oleoresin.

Performance Stability of CORTECS 2.7 μm Columns Following Repeated Injections of Precipitated Plasma
Library Number: APNT134805602 | Format: PDF | File Size: 1107.82 kB | Year: 2014 | Content Type: Application Notes

This technical note details the ruggedness of a chromatographic separation of a panel of synthetic cannabinoid drugs and metabolites following repeated injections of precipitated plasma.

Environmental Application and Method Compendium
Library Number: APNT134787739 | Format: PDF | File Size: 27912.12 kB | Year: 2014 | Content Type: Application Notes

This application notebook encompasses details about Environmental sample analysis and methods used.