Literature


Description
Improving Detection of Anabolic Steroids in Sports: Simultaneous Detection of Intact Phase I and Pha...
Library Number: APNT134876670 | Format: PDF | File Size: 1119.37 kB | Year: 2016 | Content Type: Application Notes

This application note presents a novel LC-MS/MS screening method for the simultaneous detection of intact phase I and phase II (glucuronides and sulfates) urinary metabolites of AAS.

Forensic Toxicology Application Notebook
Library Number: APNT134770639 | Format: PDF | File Size: 133261.96 kB | Year: 2016 | Content Type: Application Notes

Forensic Toxicology Application Notebook

Consumer Products Testing Application Notebook
Library Number: APNT134876628 | Format: PDF | File Size: 6645.81 kB | Year: 2016 | Content Type: Application Notes

Applications for the analytical testing of consumer products for biocides, disperse dyes, flame retardants, phthalates, and primary aromatic amines (PAAs)/Azo dyes.

Rapid Analysis of Cocaine and Metabolites by Mixed-Mode μElution SPE Combined with UPLC-MS/MS
Library Number: APNT134876342 | Format: PDF | File Size: 911.83 kB | Year: 2016 | Content Type: Application Notes

This application note details the sample extraction and UPLC-MS/MS analysis of cocaine and two of its metabolites in urine using Waters’ Oasis MCX μElution Plate.

Routine LC-MS Analysis of Intact Antibodies
Library Number: APNT134876125 | Format: PDF | File Size: 1258.81 kB | Year: 2016 | Content Type: Application Notes

This application note describes in detail the routine LC-MS analysis of intact antibodies using the Waters® mAb Mass Check Standard.

ionKey/MS System: Moving Toward Greener, More Sustainable Chemistry Methods by Reducing Mobile Phase...
Library Number: APNT134787140 | Format: PDF | File Size: 844.61 kB | Year: 2015 | Content Type: Application Notes

In this work, we present the reduction in mobile phase consumption and the associated cost savings to perform bioanalytical work by utilizing the ionKey/MS™ System.

Transferring an HPLC Method for Related Substances from Different LC Platforms to an ACQUITY Arc Sys...
Library Number: APNT134875994 | Format: PDF | File Size: 1108.23 kB | Year: 2016 | Content Type: Application Notes

This application note presents the transfer of an HPLC method for related substances of metoclopramide HCl from different LC systems to an ACQUITY Arc System.

ionKey/MS Ion Mobility: A New Approach to Authentication and Routine Screening of Ginsenoside Isomer...
Library Number: APNT134851676 | Format: PDF | File Size: 2578.05 kB | Year: 2016 | Content Type: Application Notes

In this application note, we investigate the use of Ion Mobility and UPLC separation in combination with microflow chromatography for the specific and unambiguous identification of ginsenosides.

Exploring the Benefits and Potential of iKey Microfluidic Chromatography and Time-of-Flight Mass Spe...
Library Number: APNT134819767 | Format: PDF | File Size: 3297.6 kB | Year: 2016 | Content Type: Application Notes

Enhanced ionization/transmission efficiency provides higher sensitivity to detect pesticides residues in complex food commodities at regulatory limits.

Unique Selectivity of CORTECS Phenyl for the Separation of Nitroaromatic Compounds
Library Number: APNT134875830 | Format: PDF | File Size: 946.47 kB | Year: 2016 | Content Type: Application Notes

This application note explores how effectively and efficiently nitroaromatic compounds can be separated on CORTECS Phenyl Columns.

Faster Sample Analysis of Fat Soluble Vitamins using CORTECS C8 Columns
Library Number: APNT134875843 | Format: PDF | File Size: 1038.26 kB | Year: 2016 | Content Type: Application Notes

This technology brief demonstrates how to achieve faster analysis of extremely hydrophobic compounds.

USP Method for the Impurity Analysis of Loratidine Using CORTECS C8 Columns
Library Number: APNT134875840 | Format: PDF | File Size: 812.53 kB | Year: 2016 | Content Type: Application Notes

In this application, the USP method for the impurity analysis of loratidine was transferred between three different columns.

Analysis of a Toxicology Panel Using High-efficiency CORTECS Phenyl Columns
Library Number: APNT134875854 | Format: PDF | File Size: 990.52 kB | Year: 2016 | Content Type: Application Notes

This technology brief demonstrates the performance of 1.6 μm CORTECS® Phenyl Columns for forensic toxicology applications.

High Sensitivity Quantification of Infliximab in Rat Plasma Using a Fast, Standardized Kit-Based App...
Library Number: APNT134868864 | Format: PDF | File Size: 1300.26 kB | Year: 2016 | Content Type: Application Notes

This application note describes the fast, sensitive quantification of infliximab from rat plasma using the ProteinWorks eXpress Digest Kit and Protocol.

Simple, Standardized, and Sensitive Quantification of Bevacizumab (Avastin) Using ProteinWorks eXpre...
Library Number: APNT134873721 | Format: PDF | File Size: 1184.69 kB | Year: 2016 | Content Type: Application Notes

This application note describes the fast, sensitive quantification of bevacizumab from rat plasma using the ProteinWorks eXpress Digest Kit and Protocol.

A Generic Kit-Based Approach for Quantifying Monoclonal Antibody Drugs Through Direct Digestion of D...
Library Number: APNT134873397 | Format: PDF | File Size: 1336.76 kB | Year: 2016 | Content Type: Application Notes

In this application note, we have used the ProteinWorks™ eXpress Direct Digest Kit to simplify and streamline the workflow process using the same universal protocol and reagents for all monoclonal antibody drugs tested.

Multiplexed Analysis of Steroid Hormones Using ionKey/MS
Library Number: APNT134786622 | Format: PDF | File Size: 757.9 kB | Year: 2016 | Content Type: Application Notes

In this application, we report the use of the newly developed 150 μm ionKey/ MS System for the multiplexed quantitation of 5 important steroid compounds in human serum.

Benefits and Application of Ballistic Methods
Library Number: APNT134875681 | Format: PDF | File Size: 986.43 kB | Year: 2016 | Content Type: Application Notes

This application note focuses on the creation and use of gradient ballistic methods.

Analysis of Polyethylene Glycol in Formulated Pharmaceutical Products Using CORTECS C8 Columns and t...
Library Number: APNT134875737 | Format: PDF | File Size: 263.02 kB | Year: 2016 | Content Type: Application Notes

The aim of this technology brief is to gather more data during routine analytical testing.

Performance Comparison of a Scaled USP Method for Fluconazole Using ACQUITY UPLC and Competitive UHP...
Library Number: APNT134875726 | Format: PDF | File Size: 753.5 kB | Year: 2016 | Content Type: Application Notes

This application note details the ability to scale traditional HPLC methods to modern UPLC methods providing equivalent or enhanced performance while decreasing run time and solvent consumption.

Exploring Extra Sensitivity Using ionKey/MS with the Xevo G2-XS Q-Tof HRMS for Small Molecule Pharma...
Library Number: APNT134843340 | Format: PDF | File Size: 2270.76 kB | Year: 2016 | Content Type: Application Notes

In this application note, a variety of drugs in human plasma were analyzed using several configurations of the ionKey/MS System with the Xevo G2-XS Q-Tof.

A Novel Strategy to Screen and Profile Steviol Glycosides of Natural Sweeteners in Food Using ionKey...
Library Number: APNT134851670 | Format: PDF | File Size: 2626.33 kB | Year: 2016 | Content Type: Application Notes

In this application note, ionKey/MS and ion mobility collision cross sections (CCS) is used for authentication and profiling stevioside isomers in complex food commodities.

Using the Routine Separation Dimension and Identification Criteria of ionKey/MS Ion Mobility to Enha...
Library Number: APNT134851703 | Format: PDF | File Size: 2341.8 kB | Year: 2016 | Content Type: Application Notes

In this application note, a novel microflow technique using the ACQUITY UPLC M-Class System and IM-MS that leverages both positive and negative ionization has been developed to analyze the extracts of Passiflora edulis, alata, caerulea, and incarnata.

Robustness of ionKey/MS System in the Analysis of Pharmaceutical Compounds in Biological Fluids
Library Number: APNT134783313 | Format: PDF | File Size: 1869.73 kB | Year: 2016 | Content Type: Application Notes

This work illustrates the robustness of the ionKey/MS System when analyzing complex biological samples produced by common bioanalytical sample preparation techniques.

Biopharmaceutical System Solution with UNIFI: Intact Protein Characterization
Library Number: APNT10195538 | Format: PDF | File Size: 2655.48 kB | Year: 2016 | Content Type: Application Notes

This UNIFI-based platform addresses previous limitations with a comprehensively integrated platform for data acquisition by chromatography and mass spectrometry, with automated reporting.