Literature


Description
Agrochemical Solutions Application Notebook
Library Number: APNT134851863 | Format: PDF | File Size: 18802.51 kB | Year: 2015 | Content Type: Application Notes

Application notebook covering chiral separations, synthetic chemistry, purification, formulation, trace detection, and metabolite identification for the development and manufacturing of crop protection products.

Using Gradient SmartStart Technology and an ACQUITY UPLC H-Class System to Emulate an Agilent 1100 S...
Library Number: APNT134851594 | Format: PDF | File Size: 1696.41 kB | Year: 2015 | Content Type: Application Notes

This application note illustrates the ability to successfully transfer an HPLC method to an ACQUITY UPLC H-Class System and maintain all acceptance criteria without the need to make any adjustments to the method.

A Novel Strategy to Screen and Profile Steviol Glycosides of Natural Sweeteners in Food Using ionKey...
Library Number: APNT134851670 | Format: PDF | File Size: 2626.33 kB | Year: 2015 | Content Type: Application Notes

In this application note, ionKey/MS and ion mobility collision cross sections (CCS) is used for authentication and profiling stevioside isomers in complex food commodities.

Investigating UPLC Ion Mobility Mass Spectrometry: A new Approach To Authentication and Routine Scre...
Library Number: APNT134851673 | Format: PDF | File Size: 2213.26 kB | Year: 2015 | Content Type: Application Notes

In this application note, we describe the characterization of the distribution and content of monodi- and tetra-glycosides in the raw material or processed products to illustrate how the quality and potency of ginseng products can be determined.

ionKey/MS Ion Mobility: A New Approach to Authentication and Routine Screening of Ginsenoside Isomer...
Library Number: APNT134851676 | Format: PDF | File Size: 2578.05 kB | Year: 2015 | Content Type: Application Notes

In this application note, we investigate the use of Ion Mobility and UPLC separation in combination with microflow chromatography for the specific and unambiguous identification of ginsenosides.

Routine Separation Approach to Enhance Specificity and Identification in Authentication Profiling o...
Library Number: APNT134851696 | Format: PDF | File Size: 3312.21 kB | Year: 2015 | Content Type: Application Notes

In this application note, we investigate the use of UPLC-IM-MS as a route to specific and unambiguous identification of flavonoid isomers.

Using the Routine Separation Dimension and Identification Criteria of ionKey/MS Ion Mobility to Enha...
Library Number: APNT134851703 | Format: PDF | File Size: 2341.8 kB | Year: 2015 | Content Type: Application Notes

In this application note, a novel microflow technique using the ACQUITY UPLC M-Class System and IM-MS that leverages both positive and negative ionization has been developed to analyze the extracts of Passiflora edulis, alata, caerulea, and incarnata.

Illustration of the Selectivity of Collision Cross Section Ion Mobility Screening for the Analysis ...
Library Number: APNT134851706 | Format: PDF | File Size: 2898.83 kB | Year: 2015 | Content Type: Application Notes

In this application note we explore the improved selectivity of ion mobility collision cross sections (CCS) measurements in combination with iKey microflow-LC technology for screening pesticide residues in food.

A Confirmatory Method for PCDDs and PCDFs in Compliance with EU Regulation 589/2014/EU Using Atmosph...
Library Number: APNT134851524 | Format: PDF | File Size: 1844.92 kB | Year: 2015 | Content Type: Application Notes

Coupling APGC with Xevo TQ-S provides excellent sensitivity and selectivity required for the confirmation of PCDDs and PCDFs in food and feeds in accordance with recent changes to EU Commission Regulation 589/2014/EU and associated analytical requirements...

Reaction Monitoring of a Rosuvastatin Synthesis Featuring Enantiopurity Determination by ACQUITY UPC...
Library Number: APNT134851235 | Format: PDF | File Size: 1973.65 kB | Year: 2015 | Content Type: Application Notes

The aim was to assess the applicability of ACQUITY UPC2 System coupled to a ACQUITY QDa Detector technology as a valuable solution for medicinal chemistry based reaction monitoring activities.

Measuring the Glycan Occupancy of Intact mAbs using HILIC and Detection by Intrinsic Fluorescence
Library Number: APNT134851308 | Format: PDF | File Size: 3212.56 kB | Year: 2015 | Content Type: Application Notes

This technology brief demonstrates that a Glycoprotein BEH Amide column, purposefully designed for large molecule HILIC separations, can be used to directly quantify incomplete N-glycan occupancy in intact mAb samples.

Transfer of the HPLC Method for Related Substances Analysis of Metoclopramide HCl from an Agilent 12...
Library Number: APNT134849844 | Format: PDF | File Size: 790.79 kB | Year: 2015 | Content Type: Application Notes

This technology brief demonstrates the transfer of an HPLC method for related substances of metoclopramide HCl from an Agilent 1260 Infinity LC System to an ACQUITY Arc™ System by comparing chromatographic separation and system suitability results.

Assay for Identification and Quantification of Host Cell Protein Impurities in High-Purity Monoclona...
Library Number: APNT134848391 | Format: PDF | File Size: 2925.53 kB | Year: 2015 | Content Type: Application Notes

This application note demonstrates a generic and sensitive mass spectrometric assay for the identification and quantification of host cell proteins (HCPs) that are present in highly purified biotherapeutic monoclonal antibodies (mAbs), in the concentratio...

Screening for Cannabinoids Using the Waters Forensic Toxicology Application Solution with UNIFI
Library Number: APNT134848226 | Format: PDF | File Size: 1513.99 kB | Year: 2015 | Content Type: Application Notes

This application note demonstrates the sensitivity and selectivity of the expanded Forensic Toxicology Application Solution with UNIFI using negative ionization in providing a consistent comprehensive determination of cannabinoids.

Developing High Resolution HILIC Separations of Intact Glycosylated Proteins Using a Wide-Pore Amide...
Library Number: APNT134848058 | Format: PDF | File Size: 4105.69 kB | Year: 2015 | Content Type: Application Notes

This application note presents an optimized HILIC stationary phase and corresponding methods for resolving the glycoforms of intact and digested glycoproteins.

Mapping IgG Subunit Glycoforms Using HILIC and a Wide-Pore Amide Stationary Phase
Library Number: APNT134848079 | Format: PDF | File Size: 2501.57 kB | Year: 2015 | Content Type: Application Notes

In this application note, we demonstrate the use of a glycoprotein BEH amide, 300Å, 1.7 μm column to develop LC-MS and LC-UV techniques that can be used to rapidly profile domain specific information about the N-linked glycosylation of IgG molecules.

Enhancing the Peak Capacity of High Molecular Weight N-Glycan HILIC Separations with a Wide-Pore Ami...
Library Number: APNT134848086 | Format: PDF | File Size: 1211.28 kB | Year: 2015 | Content Type: Application Notes

In this technology brief, we demonstrate the utility of an amide bonded stationary phase with an average pore diameter of 300Å (glycoprotein BEH amide, 300Å, 1.7 μm) and its ability to enhance the resolution of RapiFluor-MS labeled tri and tetra-antennary...

Screening for Melamine, Cyanuric Acid, and Dicyandiamide in Powdered Milk and Infant Formula Using M...
Library Number: APNT134847634 | Format: PDF | File Size: 1742.85 kB | Year: 2015 | Content Type: Application Notes

In this application note we describe a method using the ACQUITY UPLC H-Class System coupled to ACQUITY QDa Detector, and controlled by Empower Software for consistent and simple quantification of melamine, cyanuric acid, and dicyandiamide.

A Simple Cleanup Protocol Using a Novel SPE Device for UPLC-MS/MS
Library Number: APNT134847646 | Format: PDF | File Size: 1933.18 kB | Year: 2015 | Content Type: Application Notes

In this experiment a new solid phase extraction (SPE) device, the Oasis PRiME HLB Cartridge, was used in the sample preparation of milk samples as a cleanup method for multi-residue veterinary drug analysis.

A Simple, Fast, and Reliable LC-MS/MS Method for Determination and Quantification of Phthalates in D...
Library Number: APNT134847641 | Format: PDF | File Size: 1774.41 kB | Year: 2015 | Content Type: Application Notes

In this application note phthalates were separated on a reversed-phase column within 11 minutes using UPLC coupled to a tandem quadrupole mass spectrometer. Limits of detection (LOD) and quantification (LOQ) of seven key phthalates (DEHP, BBP, DBP, DNOP, ...

Simple, Fast, and Clean Extraction of Synthetic Cannabinoids
Library Number: APNT134847649 | Format: PDF | File Size: 1653.03 kB | Year: 2015 | Content Type: Application Notes

With Oasis PRiME HLB, a 3-step load-wash-elute SPE protocol eliminating conditioning and equilibration was successfully employed to extract 22 synthetic cannabinoids and metabolites from whole blood samples. Excellent analyte recoveries and modest matrix ...

Oasis PRiME HLB Cartridge for Effective Cleanup of Meat Extracts
Library Number: APNT134847653 | Format: PDF | File Size: 374.87 kB | Year: 2015 | Content Type: Application Notes

Fats and phospholipids are significant potential instrument and column contaminants. Oasis PRiME HLB Cartridge provides a rapid cleanup to remove these substances from meat extracts prior to LC-MS analysis.

Analysis of Plasma 17-Hydroxyprogesterone, Androstenedione, and Cortisol
Library Number: APNT134847658 | Format: PDF | File Size: 1372.91 kB | Year: 2015 | Content Type: Application Notes

Sample preparation is an important consideration for any bioanalytical LC-MS/MS method for clinical research. Waters has developed a novel sample preparation sorbent, Oasis® PRiME HLB, which is designed to have some key advantages over traditional SPE sor...

Stereoselective Separation of Triazole Fungicides Using the ACQUITY UPC2 System and ACQUITY UPC2 Tre...
Library Number: APNT134847655 | Format: PDF | File Size: 1322.52 kB | Year: 2015 | Content Type: Application Notes

In this application note we present the enantiomeric and/or diastereomeric resolutions of 12 triazole fungicides using Trefoil Column Technology.

HILIC Glycopeptide Mapping with a Wide-Pore Amide Stationary Phase
Library Number: APNT134847341 | Format: PDF | File Size: 3390.09 kB | Year: 2015 | Content Type: Application Notes

In this work, we have demonstrated the use of an ACQUITY UPLC Glycoprotein BEH Amide 300A 1.7 μm Column to obtain HILIC separations of glycopeptides that complement the chromatographic information afforded by a reversed phase separation.