Literature


Description
Method Transfer from an Agilent 1100 Series LC System to an ACQUITY UPLC H-Class System with Gradien...
Library Number: APNT134826987 | Format: PDF | File Size: 1850.17 kB | Year: 2014 | Content Type: Application Notes

Aim of this study is to transfer a reversed-phase LC gradient method for an API and its related substances from an Agilent 1100 Series LC system to an ACQUITY UPLC® H-Class System.

Analysis of Microcystins RR, LY, and YR in Bottled, Tap, and Surface Water Using ACQUITY UPLC System...
Library Number: APNT134826892 | Format: PDF | File Size: 2453.96 kB | Year: 2014 | Content Type: Application Notes

This application targeted the analysis of microcystin RR, LR, and YR in bottled, tap, and surface water.

Extraction of Testosterone from Serum using Oasis Max μElution Plates for Clinical Research
Library Number: APNT134826650 | Format: PDF | File Size: 717.25 kB | Year: 2014 | Content Type: Application Notes

This technology brief demonstrates a highly selective solid-phase extraction (SPE) technique with Oasis® MAX μElution Plates for the extraction of testosterone from serum samples for LC-MS/MS analysis in clinical research.

Simultaneous Analysis of Vitamin A and D3 in Vitamin Premixes and Concentrates by Convergence Chroma...
Library Number: APNT134826627 | Format: PDF | File Size: 1509.56 kB | Year: 2014 | Content Type: Application Notes

In this application note, we report a method for analysis of vitamin A and D3 in vitamin premixes and concentrates in one analytical run without purification or dilution.

Rapid Detection and Quantification of Selected Microsomal Substrates and Metabolites Using the Water...
Library Number: APNT134826444 | Format: PDF | File Size: 1789.55 kB | Year: 2014 | Content Type: Application Notes

In the work presented here, we show the development and validation of a rapid and sensitive LC-MS method for the simultaneous detection and quantification of multiple, selected CYP450 substrates and metabolites.

Analysis of Serum 17-Hydroxyprogesterone, Androstenedione, and Cortisol by UPLC-MS/MS for Clinical R...
Library Number: APNT134826301 | Format: PDF | File Size: 1851.72 kB | Year: 2014 | Content Type: Application Notes

In this application note a rapid method for quantification of 17-OHP, cortisol, and A4 was developed using UPLC-MS/MS.

Method Transfer from Agilent 1100 Series LC System to the ACQUITY UPLC H-Class System: The Effect of...
Library Number: APNT134825276 | Format: PDF | File Size: 893.19 kB | Year: 2014 | Content Type: Application Notes

This technology brief demonstrates the comparability of temperature selectivity effects on HPLC method transfer from an Agilent 1100 Series LC System to an ACQUITY UPLC® H-Class System.

Characterizing of the Natural Product Goldenseal using Cortecs 2.7 μm Columns and ACQUITY QDa Detect...
Library Number: APNT134825070 | Format: PDF | File Size: 1720.1 kB | Year: 2014 | Content Type: Application Notes

In this application, five different sources of Goldenseal which span four different manufacturers, two different parts of the plant, and two different formulation matrices are analyzed.

The Use of HRMS and Statistical Analysis in the Investigation of Basmati Rice Authenticity and Pote...
Library Number: APNT134824425 | Format: PDF | File Size: 3085.14 kB | Year: 2014 | Content Type: Application Notes

A proof of principle method has been established to assess the authenticity of basmati rice samples with the latest advancements in high resolution GC-MS hardware and informatics.

Direct Separations of the Six Positional Isomers of Disubstituted Benzoic Acids Using ACQUITY UPC2 T...
Library Number: APNT134823326 | Format: PDF | File Size: 1733.43 kB | Year: 2014 | Content Type: Application Notes

This study illustrates the rapid and efficient separation of all six of the possible positional isomers of both the six disubstituted dimethoxybenzoic acids and also the six dimethylbenzoic acids (DMBA).

Analysis of Aldosterone in Plasma for Clinical Research using the Xevo TQ-S micro
Library Number: APNT134823344 | Format: PDF | File Size: 525.1 kB | Year: 2014 | Content Type: Application Notes

This technology brief demonstrates the capability of Waters Xevo TQ-S micro mass spectrometer, to quantify low levels of aldosterone in plasma for clinical research using a highly selective sample preparation technique.

Improving the Cleanliness of DBS Extracts using the Ostro 96-well Sample Preparation Plate and Singl...
Library Number: APNT134632935 | Format: PDF | File Size: 1754.97 kB | Year: 2014 | Content Type: Application Notes

In this work, whole blood samples containing risperidone, its hydroxylated metabolite, 9-OH risperidone, and the internal standard, clozapine were extracted in both the traditional manner and in-well using a 96-well Ostro sample preparation plate.

Extraction of Phospholipids from Plasma using Ostro Sample Preparation
Library Number: APNT134659464 | Format: PDF | File Size: 1712.33 kB | Year: 2014 | Content Type: Application Notes

In the general protocol, the lipids are retained by the Ostro plate, and no attenpt is made to release them. Modifying the loading and elution conditions allows the same affinity to be exploited for both selective enrichment of certain classes or for tota...

0004453Rapid, Reliable Metabolite Ratio Evaluation for MIST Assessments in Drug Discovery and Precli...
Library Number: APNT134704893 | Format: PDF | File Size: 2052.3 kB | Year: 2014 | Content Type: Application Notes

To comply with U.S. FDA guidelines regarding the safety of drug metabolites in human plasma, there is a need to rapidly evaluate and accurately quantify multiple, diverse drug candidates and metabolites in a discovery or preclinical setting. Methodologie...

Rapid Sample Preparation for Determination of PAHs in Wild-Caught Avian Eggs Utilizing QuEChERS Extr...
Library Number: APNT134771183 | Format: PDF | File Size: 1323.89 kB | Year: 2014 | Content Type: Application Notes

In this application note, a rapid, high-throughput method for the preparation of eggs for the analysis of PAHs was developed using Ostro 96-well plate technology, coupled with QuEChERS dispersive extraction.

673Direct Analysis of Opioids and Metabolites from Whole Blood Using Ostro Sample Preparation Plates...
Library Number: APNT134740601 | Format: PDF | File Size: 1632.56 kB | Year: 2014 | Content Type: Application Notes

The method presented in this study demonstrates the use of Ostro Sample Preparation Plates combined with UPLC/MS/MS for the analysis of 22 opioid compounds and metabolites of interest in whole blood samples.

Multi-Residue Pesticide Analysis in Dried Chili Powder: Optimized Cleanup After QuEChERS Extraction ...
Library Number: APNT134822313 | Format: PDF | File Size: 2504.37 kB | Year: 2014 | Content Type: Application Notes

This application note presents QuEChERS extraction and SPE-based cleanup strategies for multi-residue pesticide analysis of chili powder, a highly resinous and oily material obtained from dried chili pepper fruits.

Multiresidue LC-MS/MS Screening of Veterinary Drugs in Milk Using the Ostro Sample Preparation Plate
Library Number: APNT134805080 | Format: PDF | File Size: 1866.27 kB | Year: 2014 | Content Type: Application Notes

This application note describes the use of the Ostro Plate for multi-residue screening for veterinary drugs in milk.

Advantages of Ostro Pass-through Sample Preparation Versus Solid Supported Liquid Extraction (SSLE)
Library Number: APNT134822187 | Format: PDF | File Size: 1826.82 kB | Year: 2014 | Content Type: Application Notes

In this application, a comparison is performed between Ostro Pass-through Sample Preparation and SSLE.

Successful Transfer of Size-Exclusion Separations between HPLC and UPLC
Library Number: APNT134822077 | Format: PDF | File Size: 1697.49 kB | Year: 2014 | Content Type: Application Notes

This application note will highlight the considerations that must be made when transferring an SEC method between UPLC and HPLC columns and systems.

Analysis of Artificial Food Dyes Using UltraPerformance Liquid Chromatography and an Extended Wavele...
Library Number: APNT134821857 | Format: PDF | File Size: 1721.35 kB | Year: 2014 | Content Type: Application Notes

This application note presents a fast, efficient method for the analysis of food dyes in a variety of foods.

Analysis of Glyphosate, Glufosinate, and AMPA in Tap and Surface Water Using Open-Architecture UPLC ...
Library Number: APNT134821560 | Format: PDF | File Size: 1613.96 kB | Year: 2014 | Content Type: Application Notes

In this application, the analysis of glyphosate, glyfosinate, and AMPA in water was performed using three automated sequences for the derivatization and separation.

Rapid Quantitative Analysis of Cannabidiol from Consumer Products
Library Number: APNT134821322 | Format: PDF | File Size: 1642.91 kB | Year: 2014 | Content Type: Application Notes

This application note will describe the rapid analysis of CBD from a several consumer products using UltraPerformance Convergence Chromatography™ (UPC2).

The Use of HDMS Compare Software for Comparison of Complex Polymeric Materials
Library Number: APNT134821222 | Format: PDF | File Size: 1138.06 kB | Year: 2014 | Content Type: Application Notes

In this study HDMS® Compare Software together with ion mobility mass spectrometry (IMS) has been evaluated as a comparative analytical approach to highlight and detect differences in batches of D-α-tocopheryl polyethylene glycol 1000 succinate (TPGS) pro...