Literature


Description
A Streamlined Data Dependent Acquisition (DDA) Peptide Mapping Workflow for Characterizing Therapeut...
Library Number: APNT134846439 | Format: PDF | File Size: 4791.23 kB | Year: 2015 | Content Type: Application Notes

The results presented here demonstrate the dedicated DDA peptide mapping workflow within the Biopharmaceutical Platform Solution with UNIFI.

High Sensitivity Metabolite Screening with ionKey/MS Using Post-Column Addition
Library Number: APNT134845065 | Format: PDF | File Size: 2025.24 kB | Year: 2015 | Content Type: Application Notes

In this application, ibuprofen metabolites in urine was used as an example to illustrate the enhanced sensitivity obtained by using post-column addition of isopropanol.

An LC-MS/MS Clinical Research Method for the Measurement of 25-OH Vitamin D2 and D3 Metabolites
Library Number: APNT134844722 | Format: PDF | File Size: 758.41 kB | Year: 2015 | Content Type: Application Notes

This technology brief demonstrates that the use of the ACQUITY UPLC® Online SPE Manager (OSM) enables analytically sensitive measurement of important vitamin D metabolites in plasma.

Robustness of RapiFluor-MS N-Glycan Sample Preparations and Glycan BEH Amide HILIC Chromatographic S...
Library Number: APNT134844759 | Format: PDF | File Size: 4738.47 kB | Year: 2015 | Content Type: Application Notes

In this application note, we demonstrate the robustness of RapiFluor-MS N-glycan sample preparation used in conjunction with Glycan BEH Amide HILIC Column chromatography.

Using the Waters Forensic Toxicology Screening Application Solution With UNIFI to Determine Diuretic...
Library Number: APNT134844598 | Format: PDF | File Size: 1814.13 kB | Year: 2015 | Content Type: Application Notes

This application note determines the presence of diuretics in urine, particularly at concentrations below the WADA MRPL.

Development of Integrated Informatics Workflows for the Automated Assessment of Comparability for An...
Library Number: APNT134844204 | Format: PDF | File Size: 4208.01 kB | Year: 2015 | Content Type: Application Notes

In this work, we illustrate the benefits of applying an integrated informatics workflow that has been developed for UNIFI Software to streamline data acquisition, processing, and reporting for ADC analysis by LC-UV or LC-MS.

Gas-Phase Separation of Benzocaine Protonation Site Isomers and Phenylalanine Using Travelling-Wave ...
Library Number: APNT134844042 | Format: PDF | File Size: 1342.44 kB | Year: 2015 | Content Type: Application Notes

This application note details on separation of structural isomers of benzocaine and phenylalanine by SYNAPT G2-Si HDMS Travelling-Wave (T-Wave) Ion Mobility Mass Spectrometer (IMMS).

High Sensitivity Intact Mass Analysis of Antibodies (IgG1) Using ionKey/MS
Library Number: APNT134844069 | Format: PDF | File Size: 1748.63 kB | Year: 2015 | Content Type: Application Notes

In this application note Intact Mass analysis of antibodies (IgG1) was performed using ionKey/MS.

The Use of Collision Cross Section (CCS) Measurements in Food and Environmental Analysis
Library Number: APNT134843986 | Format: PDF | File Size: 1583.84 kB | Year: 2015 | Content Type: Application Notes

In this technology note, learn how ion mobility mass spectrometry (IM-MS) offers food and environmental laboratories unique advantages for screening and profiling complex mixtures.

Using Ion Mobility for Enhanced Spectral Cleanup in Food and Environmental Analysis
Library Number: APNT134843992 | Format: PDF | File Size: 1209.82 kB | Year: 2015 | Content Type: Application Notes

In this technical note, learn how the use of ion mobility-mass spectrometry (IM-MS) can facilitate enhanced mass spectral clean up, simplifying structural elucidation and improving the efficiency of location and identification of target analytes.

Increasing Specificity and Sensitivity in Routine Peptide Analyses Using Mass Detection with the ACQ...
Library Number: APNT134843648 | Format: PDF | File Size: 2489.89 kB | Year: 2015 | Content Type: Application Notes

Here, demonstrate that the ACQUITY QDa Detector provides a simple and cost-effective solution for the acquisition of optical and MS-based data, for increased specificity in routine peptide monitoring assays associated with monoclonal antibodies (mAbs), wh...

Mass Spectrometry Application Solutions for Endocrinology Research
Library Number: APNT134843672 | Format: PDF | File Size: 10600.13 kB | Year: 2015 | Content Type: Application Notes

This application notebook offers a collection of Waters mass spectrometry application solutions for endocrinology research.

Structural Elucidation Application Notebook
Library Number: APNT134843702 | Format: PDF | File Size: 4726.98 kB | Year: 2015 | Content Type: Application Notes

In this notebook, we cover structural elucidation applications with Waters solutions. This notebook is an excerpt from the lager Waters' Application Notebook on Metabolomics and Lipidomics, P/N 720005245EN.

Untargeted Metabolomics and Lipidomics Application Notebook
Library Number: APNT134843697 | Format: PDF | File Size: 6416.8 kB | Year: 2015 | Content Type: Application Notes

In this notebook, we cover untargeted metabolomics and lipidomics applications with Waters solutions.

Targeted Metabolomics and Lipidomics Application Notebook
Library Number: APNT134843707 | Format: PDF | File Size: 5431.42 kB | Year: 2015 | Content Type: Application Notes

In this notebook, we cover targeted metabolomics and lipidomics applications with Waters solutions.

MS Imaging and Ambient Ionization-MS for Metabolomics and Lipidomics Application Notebook
Library Number: APNT134843712 | Format: PDF | File Size: 6115.96 kB | Year: 2015 | Content Type: Application Notes

In this notebook, we cover MS imaging and ambient ionization-MS application for metabolomics and lipidomics with Waters solutions.

The Use of the ACQUITY QDa Detector for a Selective, Sensitive, and Robust Quantitative Method for a...
Library Number: APNT134843332 | Format: PDF | File Size: 1778.48 kB | Year: 2015 | Content Type: Application Notes

Here, we describe an analytical method for the detection and quantitation of a GTI, 1-phenylpiperazine in an active pharmaceutical ingredient (API) at a limit of quantitation (LOQ) of 0.5 ppm relative to the API.

Exploring Extra Sensitivity Using ionKey/MS with the Xevo G2-XS Q-Tof HRMS for Small Molecule Pharma...
Library Number: APNT134843340 | Format: PDF | File Size: 2270.76 kB | Year: 2015 | Content Type: Application Notes

In this application note, a variety of drugs in human plasma were analyzed using several configurations of the ionKey/MS System with the Xevo G2-XS Q-Tof.

Screening Synthetic Adulterants from Herbal and Dietary Supplements (HDS) Using the Natural Products...
Library Number: APNT134843348 | Format: PDF | File Size: 3344.31 kB | Year: 2015 | Content Type: Application Notes

Here, we demonstrate the utility of the Natural Products Application Solution with UNIFI Adulterant Screening Application and the Synthetic Adulterant Library with the analysis of a commercial herbal supplement product.

Ultimate Resolution HPLC-Based Size Exclusion Chromatography for the Analysis of Small Proteins and ...
Library Number: APNT134841954 | Format: PDF | File Size: 1595.62 kB | Year: 2015 | Content Type: Application Notes

This application note will cover the performance characteristics of this column, designed for the separation of small proteins and peptides, with respect to UPLC method transfer, column-to-column reproducibility, and column stability.

Applying a Novel Glycan Tagging Reagent, Rapi Fluor-MS, and an Integrated UPLC-FLR/QTof MS System fo...
Library Number: APNT134841716 | Format: PDF | File Size: 1859.13 kB | Year: 2015 | Content Type: Application Notes

In this study, we demonstrate the benefits of combining RapiFluor-MS with an integrated UPLC-FLR/QTof MS system for detailed characterization of the minor glycoforms from the human IgG and mouse IgG1 samples.

Metabolomics & Lipidomics Application Notebook
Library Number: APNT134841740 | Format: PDF | File Size: 12074.22 kB | Year: 2015 | Content Type: Application Notes

In this notebook, we cover applications with Waters solutions for metabolomics and lipidomics, including untargeted and targeted analyses, structural elucidation, MS imaging, and ambient ionization-MS applications.

Lipid Visualization and Identification Through Collisional Cross Section Aided Correlation of MS Ima...
Library Number: APNT134841560 | Format: PDF | File Size: 2411.75 kB | Year: 2015 | Content Type: Application Notes

This technology brief demonstrates how collisional cross section (CCS) areas can be utilized to correlate MS imaging data with ex situ MS data followed by MS-MS identification.

Quantification of Polysorbate Using the ACQUITY UPLC H-Class Bio System with ELS Detection
Library Number: APNT134841024 | Format: PDF | File Size: 1473.08 kB | Year: 2015 | Content Type: Application Notes

In this work, we present the use of the ACQUITY UPLC H-Class Bio System with a Column Manager and an evaporative light scattering detector (ELSD) for determining the concentration of polysorbate in formulated samples.

Evaluating 2D-RP/RP Fractionation Capabilities of the ACQUITY UPLC M-Class System with 300-μm I.D. C...
Library Number: APNT134840130 | Format: PDF | File Size: 1913.07 kB | Year: 2015 | Content Type: Application Notes

This application note demonstrates the chromatographic performance of the ACQUITY UPLC M-Class System with 2D Technology for the five-step fractionation of two peptide mixtures: MIX-1 MassPREP Digestion Standard and ENL Digestion Standard.