Literature


Description
Measurement of Amino Acids and Acylcarnitines in Dried Bloodspots by Flow-Injection Analysis/Tandem ...
Library Number: APNT134952551 | Format: PDF | File Size: 535 kB | Year: 2017 | Content Type: Application Notes

This technology brief demonstrates the rapid quantification of amino acids and acylcarnitines extracted from dried bloodspots.

Determination of Fipronil and its Metabolite Fipronil Sulfone in Eggs by Liquid Chromatography-Tande...
Library Number: APNT134951097 | Format: PDF | File Size: 499.5 kB | Year: 2017 | Content Type: Application Notes

Validated method that meets requirements for both official control and food business operators’ due diligence testing, at concentrations significantly lower than the EU MRL.

Automated Protein Modification Characterization of the Intact and Subunit NIST Monoclonal Antibody R...
Library Number: APNT134949588 | Format: PDF | File Size: 2082.76 kB | Year: 2017 | Content Type: Application Notes

This study demonstrates the use of UNIFI Scientific Information System for mAb modification analysis.

Metabolomic Workflow Utilizing Rapid Microbore Metabolic Processing (RAMMP) in Conjunction with SONA...
Library Number: APNT134949722 | Format: PDF | File Size: 872.02 kB | Year: 2017 | Content Type: Application Notes

Here we demonstrate rapid metabolic profiling workflow with a novel DIA method (SONAR).

Developing Analytical Chromatographic Methods for Pharmaceutical Stability Investigations
Library Number: APNT134949157 | Format: PDF | File Size: 1180.09 kB | Year: 2017 | Content Type: Application Notes

This application describes a case study where a Quality by Design (QbD) approach was used to develop an analytical stability indicating method for monitoring degradation of amoxicillin powder for oral suspension.

Incorporation of Tetrahydrocannabinol into a Mixed Drug Substances Panel – Application to Three Comm...
Library Number: APNT134948888 | Format: PDF | File Size: 306.6 kB | Year: 2017 | Content Type: Application Notes

This technology brief demonstrates the development of a single sample preparation method, using Waters® Oasis® MCX 96-well µElution™ Plate, for the analysis of a mixed drug panel containing Tetrahydrocannabinol (THC) that can be applied to different oral ...

Determination of Vitamin D and Previtamin D in Food Products
Library Number: APNT134948173 | Format: PDF | File Size: 360.49 kB | Year: 2017 | Content Type: Application Notes

This application note demonstrates the determination of total vitamin D by individually measuring the vitamin D and previtamin D in food products.

Fast Analysis of Isoflavones in Dietary Supplements - Method Transfer to the ACQUITY UPLC H-Class Sy...
Library Number: APNT134948178 | Format: PDF | File Size: 362.53 kB | Year: 2017 | Content Type: Application Notes

We have transferred an isoflavones USP method onto an ACQUITY UPLC H-Class System and ACQUITY QDa Mass Detector, shortening the analysis time from 70 min to 8.1 min.

Pressurized Online Pepsin Digestion of mAb IgG2 for Hydrogen Deuterium Exchange Mass Spectrometry
Library Number: APNT134892458 | Format: PDF | File Size: 462.23 kB | Year: 2016 | Content Type: Application Notes

Here we report an improvement in protein digestion efficiency using a high-pressure, sustainable pepsin column – the Enzymate™ Digestion Column.

A Comprehensive Comparison of Solid Phase Extraction (SPE) vs. Solid Liquid Extraction (SLE) vs. Liq...
Library Number: APNT134947936 | Format: PDF | File Size: 407.03 kB | Year: 2017 | Content Type: Application Notes

In this application, a comprehensive comparison of sample preparation techniques conducted in plasma and urine for bioanalysis and forensic toxicology.

Quantitative Determination of Plant Growth Regulators (PGRs) in Grape Matrix Using the Xevo TQD
Library Number: APNT134947858 | Format: PDF | File Size: 862.18 kB | Year: 2017 | Content Type: Application Notes

Using a simple acetonitrile dilution followed by liquidliquid extraction, all pesticides were successfully extracted from the grape matrix and analyzed in an 8 minute run.

Phosphatidylethanol (PEth) – A Direct Biomarker for Ethanol Abuse Analyzed with UPLC-MS/MS for Foren...
Library Number: APNT134946929 | Format: PDF | File Size: 391.67 kB | Year: 2017 | Content Type: Application Notes

An improved chromatographic method for the sensitive measurement of PEth in Whole blood.

An Example of a Particle Selectivity Difference between CORTECS C8 and BEH C8 Columns
Library Number: APNT134946242 | Format: PDF | File Size: 439.51 kB | Year: 2017 | Content Type: Application Notes

The separation of structurally similar compounds is described in this application note.

Effective Determination of Pharmaceutical Impurities by Two Dimensional Liquid Chromatography
Library Number: APNT134946059 | Format: PDF | File Size: 1256.98 kB | Year: 2017 | Content Type: Application Notes

Analysis of API and related impurities is studied using 2DLC.

Improved Multi-Analyte Method for the Underivatized Analysis of Anionic Pesticides in Food by LC-MS/...
Library Number: APNT134945966 | Format: PDF | File Size: 1002.96 kB | Year: 2017 | Content Type: Application Notes

Quantitative determination of an extended suite of eight anionic polar pesticides, which are not amenable to conventional reverse-phase chromatography by LC-MS/MS.

Peptide Separations Application Notebook
Library Number: APNT134916452 | Format: PDF | File Size: 67630.26 kB | Year: 2017 | Content Type: Application Notes

This document is a compilation of published LC & LC-MS applications for the analyses of peptides.

Peptide Separations Application Notebook - Peptide Mapping for Protein Characterization Chapter
Library Number: APNT134923096 | Format: PDF | File Size: 31663.83 kB | Year: 2017 | Content Type: Application Notes

Application notes on peptide mapping for protein characterization.

Analysis of 5-Fluorouracil in Plasma for Clinical Research
Library Number: APNT134945127 | Format: PDF | File Size: 774.78 kB | Year: 2017 | Content Type: Application Notes

Here we describe a analytically sensitive and selective clinical research method for the analysis of plasma 5-fluorouracil.

Mass Confirmation of Cannabinoids in Cannabis sativa by using HPTLC-QDa
Library Number: APNT134943848 | Format: PDF | File Size: 553.99 kB | Year: 2017 | Content Type: Application Notes

Identification and Confirmation of Cannabinoids in Cannabis Sativa is described by using HPTLC and Acquity QDa Detector.

High Throughput DESI Imaging for Optimized Analysis of Biological Tissues
Library Number: APNT134944932 | Format: PDF | File Size: 2409.18 kB | Year: 2017 | Content Type: Application Notes

This technology brief demonstrates the optimization of a DESI imaging workflow to allow high throughput sample analysis.

Increased Specificity, Improved Lipidomic Clarity, and Identification Confidence with SONAR
Library Number: APNT134944356 | Format: PDF | File Size: 712.46 kB | Year: 2017 | Content Type: Application Notes

Here we describe the application of SONAR for the identification of Lipids.

Mass Confirmation of Sibutramine by HPTLC-QDa in Herbal Natural Products
Library Number: APNT134943927 | Format: PDF | File Size: 440.61 kB | Year: 2017 | Content Type: Application Notes

Here we identify and confirm the presence of sibutramine in finished herbal natural products.

Metabolic Phenotyping of Colorectal Tissue Samples by DESI-MSI for Clinical Research
Library Number: APNT134943792 | Format: PDF | File Size: 2983.17 kB | Year: 2017 | Content Type: Application Notes

This technology brief elucidates the metabolic changes associated with cancer progression and invasion in clinical research.

Ex vivo Lung Perfusion Tissue Analysis by Desorption Electrospray Ionization (DESI) Imaging in Clini...
Library Number: APNT134943816 | Format: PDF | File Size: 1238.5 kB | Year: 2017 | Content Type: Application Notes

This technology brief demonstrates Ex vivo Lung Perfusion Tissue Analysis by DESI Imaging.

Advantages of Ion Mobility for MALDI Imaging of N-glycans from Tumor Bearing FFPE Tissue in Clinical...
Library Number: APNT134943826 | Format: PDF | File Size: 2191.85 kB | Year: 2017 | Content Type: Application Notes

This technology brief describes the separation of N-glycans isobaric species by ion mobility.