Literature


Description
Utilizing UPLC/MS for Conducting Forced Degradation Studies
Library Number: 720002259EN | Format: PDF | File Size: 859.6 kB | Year: 2015 | Content Type: Application Notes

In this application note, we demonstrate the ability of an ACQUITY UPLC system combined with an ACQUITY UPLC PDA and SQ mass spectrometer to separate degradation products in simvastatin.

A Stress Testing Study of Glimepiride Drug Substance Utilizing UPLC/MS Methodology
Library Number: APNT10073775 | Format: PDF | File Size: 1554.88 kB | Year: 2015 | Content Type: Application Notes

In this application, a forced degradation study will be performed for the drug substance glimepiride. UPLC and the Empower 2 Software chromatography data system facilitate the analysis of the degradation behavior of drug substances during stress testing.

Rapid, Simple Impurity Characterization with the Xevo TQ MS
Library Number: APNT10093138 | Format: PDF | File Size: 2445.65 kB | Year: 2015 | Content Type: Application Notes

The rapid switching between MS and MS/MS possible with the Xevo TQ MS allows the collection of qualitative data and quantitative data in the same analytical run, with high sensitivity.

Detection and Identification of Synthetic Phosphodiesterase Type-5 Inhibitors in Adulterated Herbal ...
Library Number: APNT10119959 | Format: PDF | File Size: 2731.12 kB | Year: 2015 | Content Type: Application Notes

In this work, we evaluate the use of the Xevo TQ MS for the detection and identification of adulterants in herbal supplements.

Identification and Characterization of an Isolated Impurity Fraction: Analysis of an Unknown Degrada...
Library Number: APNT10130890 | Format: PDF | File Size: 1953.45 kB | Year: 2015 | Content Type: Application Notes

We demonstrate the application of high-resolution mass spectrometry to generate exact mass MS/MS fragment analysis data in conjunction with the use of software to automatically identify product ion fragments.

A Workflow Approach for the Identification and Structural Elucidation of Impurities of Quetiapine He...
Library Number: APNT10131073 | Format: PDF | File Size: 1864.54 kB | Year: 2015 | Content Type: Application Notes

We explore a multidisciplinary approach to impurity analysis using a systematic workflow that is capable of highly specific and highly sensitive detection and determination of impurities that are present in quetiapine hemifumarate active pharmaceutical in...

Small Scale Purification of Constituents from Complex Natural Product Extracts Using ACQUITY H-Class...
Library Number: APNT134853975 | Format: PDF | File Size: 2045.47 kB | Year: 2015 | Content Type: Application Notes

This application note will demonstrate several collection features of the WFM-A, a fraction collector designed to collect peaks generated from sub-2-μm chromatography using 3 natural product extracts.

Purification of Vanillin from Vanilla Beans Using an SFE-SFC Workflow
Library Number: APNT134853984 | Format: PDF | File Size: 2055.84 kB | Year: 2015 | Content Type: Application Notes

This application note demonstrates a complete SFE-SFC workflow solution using an MV-10 ASFE System (MV-10) and a Prep 80q SFC System for the extraction and purification of vanillin from whole vanilla beans.

Peptide Isolation Using the Prep 150 LC System
Library Number: APNT134854010 | Format: PDF | File Size: 1872.95 kB | Year: 2015 | Content Type: Application Notes

This application note demonstrates the analysis and UV-directed purification of a synthetic peptide using an Alliance HPLC System for screening and a Prep 150 LC System for isolation.

Transfer of an HPLC Method from an Agilent 1100 Series LC System to an Alliance HPLC System
Library Number: APNT134853248 | Format: PDF | File Size: 927.96 kB | Year: 2015 | Content Type: Application Notes

This technology brief demonstrates the successful transfer of an HPLC method from an Agilent 1100 Series LC System to an Alliance® HPLC System with minimal adjustments to the method.

Multi-Residue Pesticide Analysis in Dried Chili Powder: Optimized Cleanup After QuEChERS Extraction ...
Library Number: APNT134853818 | Format: PDF | File Size: 2473.13 kB | Year: 2015 | Content Type: Application Notes

This application note presents QuEChERS extraction and SPE-based cleanup strategies for multi-residue pesticide analysis of chili powder, a highly resinous and oily material obtained from dried chili pepper fruits.

Extraction and Isolation of a Natural Product from Schisandra Berry Extract Using SFE and SFC
Library Number: APNT134853506 | Format: PDF | File Size: 1638.7 kB | Year: 2015 | Content Type: Application Notes

In this study, we focus on the feasibility of using the Prep 100q SFC System as a tool for isolating schisandrin A from dry schisandra berries extracted using supercritical fluid extraction (SFE).

Qualitative Pesticide Screening of a Dried Cherry Sample Using HRMS
Library Number: APNT134853468 | Format: PDF | File Size: 2116.65 kB | Year: 2015 | Content Type: Application Notes

In this application note we demonstrate how a user can get from injection of a sample to submission of an accurate report using the workflows, views, and filters in UNIFI for multi-analyte screening in food and environmental samples.

Simple HRMS Data Review Using Workflows, Views, and Filters Within a Novel Integrated Scientific Inf...
Library Number: APNT134852938 | Format: PDF | File Size: 2043.76 kB | Year: 2015 | Content Type: Application Notes

In this technical note, we demonstrate the ease of use and efficacy of a non-targeted, data independent, analysis type MS(E) and HDMS(E), coupled with UNIFI, a state-of-the-art scientific information system, for multi-analyte screening in food and environ...

ACQUITY UPLC M-Class System: Small Molecule Chromatographic Performance with 1.0-mm Diameter Microsc...
Library Number: APNT134852425 | Format: PDF | File Size: 985.25 kB | Year: 2015 | Content Type: Application Notes

This technology brief demonstrates chromatographic performance of the ACQUITY UPLC® M-Class System for small molecule separations on 1.0-mm diameter columns packed with sub-2-μm particles.

Agrochemical Solutions Application Notebook
Library Number: APNT134851863 | Format: PDF | File Size: 18802.51 kB | Year: 2015 | Content Type: Application Notes

Application notebook covering chiral separations, synthetic chemistry, purification, formulation, trace detection, and metabolite identification for the development and manufacturing of crop protection products.

Using Gradient SmartStart Technology and an ACQUITY UPLC H-Class System to Emulate an Agilent 1100 S...
Library Number: APNT134851594 | Format: PDF | File Size: 1696.41 kB | Year: 2015 | Content Type: Application Notes

This application note illustrates the ability to successfully transfer an HPLC method to an ACQUITY UPLC H-Class System and maintain all acceptance criteria without the need to make any adjustments to the method.

A Novel Strategy to Screen and Profile Steviol Glycosides of Natural Sweeteners in Food Using ionKey...
Library Number: APNT134851670 | Format: PDF | File Size: 2626.33 kB | Year: 2015 | Content Type: Application Notes

In this application note, ionKey/MS and ion mobility collision cross sections (CCS) is used for authentication and profiling stevioside isomers in complex food commodities.

Investigating UPLC Ion Mobility Mass Spectrometry: A New Approach to Authentication and Routine Scre...
Library Number: APNT134851673 | Format: PDF | File Size: 2213.26 kB | Year: 2015 | Content Type: Application Notes

In this application note, we describe the characterization of the distribution and content of mono-di- and tetra-glycosides in the raw material or processed products to illustrate how the quality and potency of ginseng products can be determined.

ionKey/MS Ion Mobility: A New Approach to Authentication and Routine Screening of Ginsenoside Isomer...
Library Number: APNT134851676 | Format: PDF | File Size: 2578.05 kB | Year: 2015 | Content Type: Application Notes

In this application note, we investigate the use of Ion Mobility and UPLC separation in combination with microflow chromatography for the specific and unambiguous identification of ginsenosides.

Routine Separation Approach to Enhance Specificity and Identification in Authentication Profiling o...
Library Number: APNT134851696 | Format: PDF | File Size: 3312.21 kB | Year: 2015 | Content Type: Application Notes

In this application note, we investigate the use of UPLC-IM-MS as a route to specific and unambiguous identification of flavonoid isomers.

Illustration of the Selectivity of Collision Cross Section Ion Mobility Screening for the Analysis ...
Library Number: APNT134851706 | Format: PDF | File Size: 2898.83 kB | Year: 2015 | Content Type: Application Notes

In this application note we explore the improved selectivity of ion mobility collision cross sections (CCS) measurements in combination with iKey microflow-LC technology for screening pesticide residues in food.

Using the Routine Separation Dimension and Identification Criteria of ionKey/MS Ion Mobility to Enha...
Library Number: APNT134851703 | Format: PDF | File Size: 2341.8 kB | Year: 2015 | Content Type: Application Notes

In this application note, a novel microflow technique using the ACQUITY UPLC M-Class System and IM-MS that leverages both positive and negative ionization has been developed to analyze the extracts of Passiflora edulis, alata, caerulea, and incarnata.

A Confirmatory Method for PCDDs and PCDFs in Compliance with EU Regulation 589/2014/EU Using Atmosph...
Library Number: APNT134851524 | Format: PDF | File Size: 1844.92 kB | Year: 2015 | Content Type: Application Notes

Coupling APGC with Xevo TQ-S provides excellent sensitivity and selectivity required for the confirmation of PCDDs and PCDFs in food and feeds in accordance with recent changes to EU Commission Regulation 589/2014/EU and associated analytical requirements...

Reaction Monitoring of a Rosuvastatin Synthesis Featuring Enantiopurity Determination by ACQUITY UPC...
Library Number: APNT134851235 | Format: PDF | File Size: 1973.65 kB | Year: 2015 | Content Type: Application Notes

The aim was to assess the applicability of ACQUITY UPC2 System coupled to a ACQUITY QDa Detector technology as a valuable solution for medicinal chemistry based reaction monitoring activities.