Literature


Description
Amino Acid Analysis Application Notebook
Library Number: APNT134965704 | Format: PDF | File Size: 23451.39 kB | Year: 2018 | Content Type: Application Notes

This application notebook describes solutions to Amino acid analysis.

Efficient Extraction of Quetiapine in Plasma Using Oasis PRiME MCX
Library Number: APNT134965716 | Format: PDF | File Size: 188.88 kB | Year: 2018 | Content Type: Application Notes

This application note describes the analysis of quetiapine using sample extraction protocols.

Simultaneous Quantification of Saxagliptin, 5-Hydroxy Saxagliptin, and Dapagliflozin in Human Plasma...
Library Number: APNT134965342 | Format: PDF | File Size: 412.43 kB | Year: 2018 | Content Type: Application Notes

This application details the simultaneous extraction and quantification of saxagliptin and its major active metabolites in human plasma.

Accurate Quantification of intact Insulin-like Growth Factor I (IGF-I) using High Resolution Mass Sp...
Library Number: APNT134965293 | Format: PDF | File Size: 590.77 kB | Year: 2018 | Content Type: Application Notes

The robust quantification of intact IGF-1 is highlighted in this technology brief.

LC-MS/MS Quantification of Intact Insulin-Like Growth Factor I (IGF-I) in Serum
Library Number: APNT134957115 | Format: PDF | File Size: 393.1 kB | Year: 2017 | Content Type: Application Notes

This application note describes about direct analysis and quantification of intact IGF-I from serum/plasma.

An Untargeted Exposure Study of Small Isolated Populations Using Atmospheric Gas Chromatography Coup...
Library Number: APNT134965044 | Format: PDF | File Size: 1414.95 kB | Year: 2018 | Content Type: Application Notes

Exposure studies involve complex data and subtle comparisons within the data sets. By utilizing the soft ionization of APGC and acquiring accurate mass data on both precursor and fragment ions in one method, a complete dataset can be produced.

Increasing Throughput for the Analysis of Human Insulin and Related Biotherapeutic Analogs using the...
Library Number: APNT134957868 | Format: PDF | File Size: 1037.76 kB | Year: 2017 | Content Type: Application Notes

This study demonstrates highly sensitive, accurate and robust analysis of human insulin and related biotherapeutic analogs.

A Comparative Qualitative and Quantitative Assessment of SONAR for High-Throughput Proteomic Applica...
Library Number: APNT134964654 | Format: PDF | File Size: 517.67 kB | Year: 2017 | Content Type: Application Notes

This application note describes a qualitative and quantitative protein identifications using SONAR mode of acquisition.

LC-MRM Quantification of Hamster Phospholipase B-Like 2 Protein (PLBL2) in Therapeutic Monoclonal An...
Library Number: APNT134964691 | Format: PDF | File Size: 1007.64 kB | Year: 2017 | Content Type: Application Notes

In this application note an LC-MRM assay is developed for the quantification of a ubiquitous low-level host cell protein across multiple preparations of biopharmaceuticals.

Simultaneous Extraction of Metformin, Linagliptin and Empagliflozin From Human Plasma Using Mixed-Mo...
Library Number: APNT134964529 | Format: PDF | File Size: 163.76 kB | Year: 2017 | Content Type: Application Notes

This application highlights simultaneous analysis of Metformin, Linagliptin, and Empagliflozin from plasma

Accurate Compound Identification from Complex Natural Product Samples Using SONAR
Library Number: APNT134964172 | Format: PDF | File Size: 1291 kB | Year: 2017 | Content Type: Application Notes

This technology brief demonstrates accurate compound identification from complex natural product samples.

An Integrated LC-MS Platform for Multi-Attribute Monitoring of CQA’s of mAbs at the Subunit Level
Library Number: APNT134963558 | Format: PDF | File Size: 1678.45 kB | Year: 2017 | Content Type: Application Notes

This application note demonstrates the use of LC-MS platform under compliant-ready software UNIFI for protein characterization.

Using Mass Detection as an Orthogonal Technology to Improve Routine Analysis of Biotherapeutics
Library Number: APNT134962992 | Format: PDF | File Size: 453.46 kB | Year: 2017 | Content Type: Application Notes

This application note demonstrates how the addition of the ACQUITY QDa can improve the confidence and productivity when carrying out routine analysis of biotherapeutics.

Improving Quantitative Analysis of Red Wine Using the Xevo G2-XS QTof with SONAR Data Independent Ac...
Library Number: APNT134962853 | Format: PDF | File Size: 426.05 kB | Year: 2017 | Content Type: Application Notes

In this technical note we describe the use of a novel data independent acquisition (DIA) mode known as SONAR for generation of highly selective HRMS spectra on Waters Xevo G2-XS QTof.

Analysis of Antidiabetic Drug Canagliflozin and Related Isomeric Impurities Using the ACQUITY UPC2 S...
Library Number: APNT134961702 | Format: PDF | File Size: 729.95 kB | Year: 2017 | Content Type: Application Notes

This application note demonstrates the separation of Canagliflozin and its isomeric impurities.

Characterizing Low Abundance Monoclonal Antibody PTMs Using UNIFI Scientific Information System Pept...
Library Number: APNT134961689 | Format: PDF | File Size: 506.3 kB | Year: 2017 | Content Type: Application Notes

This application not describes peptide PTM analysis using UNIFI with Vion IMS QTof MS system.

Method Modernization for Routine Analysis of Biotherapeutics as Part of Lifecycle Management
Library Number: APNT134961717 | Format: PDF | File Size: 244.65 kB | Year: 2017 | Content Type: Application Notes

This application note describes how the modernization of a USP monograph can increase throughput and productivity in a routine environment.

An Efficient UV-Based Method for the Assessment of Oleic Acid Content in Biotherapeutic Drug Product...
Library Number: APNT134961587 | Format: PDF | File Size: 410.55 kB | Year: 2017 | Content Type: Application Notes

Determination of Oleic Acid concentration in drug products is studied in this app note.

Improved Performance of Waters Alliance HPLC System for System Suitability Results of Area RSD for E...
Library Number: APNT134961208 | Format: PDF | File Size: 132.1 kB | Year: 2017 | Content Type: Application Notes

This application note demonstrates the improved performance of Alliance HPLC system.

Guidelines for the Determination of Compound Recovery on the Waters AutoPurification System
Library Number: APNT134961216 | Format: PDF | File Size: 1010.72 kB | Year: 2017 | Content Type: Application Notes

This application note discusses the guidelines for the determination of compound recovery on Waters AutoPurification System.

Combining Multiple Acquisition Channels for Analysis of Impurities Using Empower 3 Software
Library Number: APNT134961049 | Format: PDF | File Size: 664.94 kB | Year: 2017 | Content Type: Application Notes

This technology brief illustrates use of Empower Software for combining multiple MS SIR channels for analysis of potential genotoxic impurities (PGIs).

Purification Application Notebook
Library Number: APNT134959176 | Format: PDF | File Size: 4994.34 kB | Year: 2017 | Content Type: Application Notes

This note book describes about application solutions for Preparative-Scale Chromatography.

Analysis of Dioxins and Furans on a Xevo G2-XS QTof with APGC Using a QuEChERS Extraction Method
Library Number: APNT134959271 | Format: PDF | File Size: 654.31 kB | Year: 2017 | Content Type: Application Notes

Dioxin method that is faster and more cost effective than the traditional magnetic sector technique using APGC-Xevo G2-XS QTof high resolution mass spectrometry (HRMS) -while exceeding the minimum performance limits required for EPA method 1613.

Metabolite Identification: Working with Large Preclinical Multispecies Data Sets
Library Number: APNT134959055 | Format: PDF | File Size: 2461.57 kB | Year: 2017 | Content Type: Application Notes

This application note outlines the use of integrated quantitative and qualitative processing for managing multispecies studies.

Integrating Ion Mobility into Routine Metabolite Identification Studies Using the Vion IMS QTof Mass...
Library Number: APNT134956341 | Format: PDF | File Size: 929.81 kB | Year: 2017 | Content Type: Application Notes

This application note outlines and focuses on the benefits and the ease of use of ion mobility for the application of metabolite identification.