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Quantitative Analysis of Dried Bloodspot 17-Hydroxyprogesterone by ACQUITY UPLC-MS/MS for Clinical R...
Library Number: APNT134793199 | Format: PDF | File Size: 1596.55 kB | Year: 2014 | Content Type: Application Notes

In this application note a method for the extraction and UPLC-MS/MS analysis of DBS 17-OHP using the ACQUITY UPLC System with the Xevo TQ MS Detector is described.

Application Notebook: The Path to Successful Drug Development Starts with Purposeful Method Developm...
Library Number: APNT134793711 | Format: PDF | File Size: 13180.52 kB | Year: 2014 | Content Type: Application Notes

This compilation of application notes demonstrates a purposeful approach to method development. Using integrated analytical technologies, standards, and workflows, scientists can produce more robust and reliable methods.

Chromatographic Reproducibility of the Novel ionKey/MS System
Library Number: APNT134786610 | Format: PDF | File Size: 858.32 kB | Year: 2014 | Content Type: Application Notes

This technology brief evaluates the chromatographic retention time and system reproducibility of Waters® ionKey/MS™ System

Video - Managing Selectivity of Hydrophobic and Hydrophilic Compounds with HILIC and RP-LC
Library Number: APNT134790639 | Format: Web Page | File Size: - | Year: 2014 | Content Type: Application Notes

Dr. Tom Wheat discusses how to use both reversed-phase LC and HILIC modes on the ACQUITY UPLC H-Class System. He also addresses how the ACQUITY QDA Detector enables use of both UV and mass to monitor components with different responses.

Video - Using Small Modifications of pH in Chromatographic Methods Development
Library Number: APNT134790676 | Format: Web Page | File Size: - | Year: 2013 | Content Type: Application Notes

In this video, Paula Hong discusses ways to make the development of chromatographic separations more effective and more efficient by using pH and AutoBlend Plus.

Multi-Residue Pesticide Analysis in Ginseng Powder: Optimized Cleanup After QuEChERS Extraction for ...
Library Number: APNT134790755 | Format: PDF | File Size: 1567.61 kB | Year: 2014 | Content Type: Application Notes

This application note presents QuEChERS extraction and SPE-based cleanup strategies for multi-residue pesticide analysis of American ginseng powder, a highly resinous root material commonly used as an herbal supplement.

A Method for the Rapid and Simultaneous Analysis of Sweeteners in Various Food Products Using the AC...
Library Number: APNT134791123 | Format: PDF | File Size: 1737.95 kB | Year: 2014 | Content Type: Application Notes

In this application note, a fast, reliable, and sensitive method for the identification and quantification of sweeteners has been developed for food and beverage manufacturers.

Fast Separation of 20 Steroids Including Isobaric Species using UPC2/MS/MS
Library Number: APNT134791604 | Format: PDF | File Size: 1061.94 kB | Year: 2014 | Content Type: Application Notes

In this application, 20 steroids were separated on an ACQUITY UPC2™ BEH 2-EP Column in under 7 minutes, using a co-solvent of IPA/MeOH modified with formic acid.

Ultrasensitive Quantification Assay for Oxytocin in Human Plasma Using the ionKey/MS System
Library Number: APNT134791713 | Format: PDF | File Size: 1781.93 kB | Year: 2014 | Content Type: Application Notes

This application note describes an LC-MRM method developed on the ionKey/MS System that is able to detect very low levels of OT in human plasma, at an LLOQ of 10 pg/mL.

High-Throughput LC/MS MRM Disease Protein Marker Verification Using the ionKey/MS System
Library Number: APNT134791724 | Format: PDF | File Size: 1460.83 kB | Year: 2014 | Content Type: Application Notes

The application of a novel microfluidics platform for the quantification of marker peptides and proteins is presented, considering speed, sensitivity, and selectivity.

Robustness of ionKey/MS System in the Analysis of Pharmaceutical Compounds in Biological Fluids
Library Number: APNT134783313 | Format: PDF | File Size: 1869.73 kB | Year: 2014 | Content Type: Application Notes

This work illustrates the robustness of the ionKey/MS System when analyzing complex biological samples produced by common bioanalytical sample preparation techniques.

Multiplexed Analysis of Steroid Hormones Using ionKey/MS
Library Number: APNT134786622 | Format: PDF | File Size: 1227.62 kB | Year: 2014 | Content Type: Application Notes

In this application, we report the use of the newly developed 150 μm ionKey/ MS System for the multiplexed quantitation of 5 important steroid compounds in human serum.

An Improved SPE-LC-MS/MS Method for the Quantification of Bradykinin in Human Plasma Using the ionKe...
Library Number: APNT134786602 | Format: PDF | File Size: 1839.48 kB | Year: 2014 | Content Type: Application Notes

This application note describes the method for the quantification of Bradykinin in Human Plasma Using the ionKey/MS System.

Targeted Lipidomics Using the ionKey/MS System
Library Number: APNT134786958 | Format: PDF | File Size: 1721.99 kB | Year: 2014 | Content Type: Application Notes

This application note demonstrates the use of novel ionKey/MS System, which utilizes the iKey™ Separation Device packed with 1.7 μm particles for fast and robust chromatographic separation.

Pesticide Screening of Food Samples Using the ionKey/MS System
Library Number: APNT134787026 | Format: PDF | File Size: 1598.28 kB | Year: 2014 | Content Type: Application Notes

In this application note, The ionKey/MS System, a novel microfluidics-MS platform, was assessed for the micro-LC analysis of pesticides in food samples.

ionKey/MS System: Moving Toward Greener, More Sustainable Chemistry Methods by Reducing Mobile Phase...
Library Number: APNT134787140 | Format: PDF | File Size: 844.61 kB | Year: 2014 | Content Type: Application Notes

In this work, we present the reduction in mobile phase consumption and the associated cost savings to perform bioanalytical work by utilizing the ionKey/MS™ System.

Rapid Analysis of Sudan and Other Prohibited Dyes in Chili Powder Using the ACQUITY UPLC H-Class Sys...
Library Number: APNT134787660 | Format: PDF | File Size: 1577.85 kB | Year: 2014 | Content Type: Application Notes

In this application note, a fast and sensitive method utilizing a QuEChERS extraction procedure, UPLC separation with MS/MS for the detection and quantification of 11 Sudan and azo-dyes is presented.

A Validated Method for the Analysis of 142 Pesticide Residues Using Atmospheric Pressure GC Coupled ...
Library Number: APNT134788107 | Format: PDF | File Size: 1284.6 kB | Year: 2014 | Content Type: Application Notes

In this application note we describe the development and validation of a highly sensitive, multi-class method for the routine determination of 142 pesticide residues in QuEChERS extracts of various fruit and vegetables using APGC and Xevo TQ-S.

The Development of a Sensitive Multi-Residue LC-MS/MS Method for the Quantitative Determination of M...
Library Number: APNT134788864 | Format: PDF | File Size: 1870.85 kB | Year: 2014 | Content Type: Application Notes

In this application note, we report the development of a quantitative method for the determination of 33 relevant mycotoxins in a variety of animal feed and silage extracts.

Improving a High Sensitivity Assay for the Quantification of Teriparatide in Human Plasma Using the ...
Library Number: APNT134788933 | Format: PDF | File Size: 2163.87 kB | Year: 2014 | Content Type: Application Notes

This study combines μElution SPE and the novel and highly efficient ionKey/MS system to improve a quantitative assay for teriparatide in human plasma.

Simple Guidelines for Choosing the Right Injection Solvent for UltraPerformance Convergence Chromato...
Library Number: APNT134789282 | Format: PDF | File Size: 852.52 kB | Year: 2014 | Content Type: Application Notes

This technology brief provide general guidelines regarding the choice of sample injection solvents based on the analyte and stationary phase properties when performing separations on an ACQUITY UPC2™ System.

Improving Decision Making during Method Development Using Empower 3 CDS Software
Library Number: APNT134789312 | Format: PDF | File Size: 948.58 kB | Year: 2014 | Content Type: Application Notes

This technology brief demonstrates the capabilities of Empower® 3 Software for scoring chromatographic separations using custom calculations and custom reports.

Minimizing Carryover During Dioxin Analysis Using the Xevo TQ-S with APGC
Library Number: APNT134789354 | Format: PDF | File Size: 799 kB | Year: 2014 | Content Type: Application Notes

In this technology brief, confident and accurate analysis of dioxins and furans can be performed using the prescribed method.

Sensitive and Repeatable Analysis of Pesticides in QuEChERS Extracts with APGC-MS/MS
Library Number: APNT134789863 | Format: PDF | File Size: 1507.47 kB | Year: 2014 | Content Type: Application Notes

In this application note, we demonstrate that the Waters Xevo TQ-S equipped with an APGC source provides a sensitive and repeatable solution for the analysis of pesticides in QuEChERS extracts of strawberry, pear, and spinach.

Chiral and Achiral Profiling of a Pesticide Formulation Using the ACQUITY UPC2 System and the ACQUIT...
Library Number: APNT134790013 | Format: PDF | File Size: 1490.81 kB | Year: 2014 | Content Type: Application Notes

In this application note, we describe the analytical profiling of a triazole containing pesticide formulation using UPC2 and a combination of UV and mass detection.