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Improving Effectiveness in Method Development by Using a Systematic Screening Protocol for a USP Met...
Library Number: APNT134794256 | Format: PDF | File Size: 1669.7 kB | Year: 2014 | Content Type: Application Notes

Following a systematic protocol, we have successfully developed a UPLC method for the separation of metoclopramide and related compounds. The criteria for success with a goal of separating all nine components, achieving a resolution of ≥2.0, tailing of ≤1...

Quantitative Analysis of Dried Bloodspot 17-Hydroxyprogesterone by ACQUITY UPLC-MS/MS for Clinical R...
Library Number: APNT134793199 | Format: PDF | File Size: 1596.55 kB | Year: 2014 | Content Type: Application Notes

In this application note a method for the extraction and UPLC-MS/MS analysis of DBS 17-OHP using the ACQUITY UPLC System with the Xevo TQ MS Detector is described.

Fast Separation of 20 Steroids Including Isobaric Species using UPC2/MS/MS
Library Number: APNT134791604 | Format: PDF | File Size: 1061.94 kB | Year: 2014 | Content Type: Application Notes

In this application, 20 steroids were separated on an ACQUITY UPC2™ BEH 2-EP Column in under 7 minutes, using a co-solvent of IPA/MeOH modified with formic acid.

Ultrasensitive Quantification Assay for Oxytocin in Human Plasma Using the ionKey/MS System
Library Number: APNT134791713 | Format: PDF | File Size: 1781.93 kB | Year: 2014 | Content Type: Application Notes

This application note describes an LC-MRM method developed on the ionKey/MS System that is able to detect very low levels of OT in human plasma, at an LLOQ of 10 pg/mL.

High-Throughput LC/MS MRM Disease Protein Marker Verification Using the ionKey/MS System
Library Number: APNT134791724 | Format: PDF | File Size: 1460.83 kB | Year: 2014 | Content Type: Application Notes

The application of a novel microfluidics platform for the quantification of marker peptides and proteins is presented, considering speed, sensitivity, and selectivity.

Chromatographic Reproducibility of the Novel ionKey/MS System
Library Number: APNT134786610 | Format: PDF | File Size: 858.32 kB | Year: 2014 | Content Type: Application Notes

This technology brief evaluates the chromatographic retention time and system reproducibility of Waters® ionKey/MS™ System

The Development of a Sensitive Multi-Residue LC-MS/MS Method for the Quantitative Determination of M...
Library Number: APNT134788864 | Format: PDF | File Size: 1870.85 kB | Year: 2014 | Content Type: Application Notes

In this application note, we report the development of a quantitative method for the determination of 33 relevant mycotoxins in a variety of animal feed and silage extracts.

Simple Guidelines for Choosing the Right Injection Solvent for UltraPerformance Convergence Chromato...
Library Number: APNT134789282 | Format: PDF | File Size: 852.52 kB | Year: 2014 | Content Type: Application Notes

This technology brief provide general guidelines regarding the choice of sample injection solvents based on the analyte and stationary phase properties when performing separations on an ACQUITY UPC2™ System.

Improving a High Sensitivity Assay for the Quantification of Teriparatide in Human Plasma Using the ...
Library Number: APNT134788933 | Format: PDF | File Size: 2163.87 kB | Year: 2014 | Content Type: Application Notes

This study combines μElution SPE and the novel and highly efficient ionKey/MS system to improve a quantitative assay for teriparatide in human plasma.

Improving Decision Making during Method Development Using Empower 3 CDS Software
Library Number: APNT134789312 | Format: PDF | File Size: 948.58 kB | Year: 2014 | Content Type: Application Notes

This technology brief demonstrates the capabilities of Empower® 3 Software for scoring chromatographic separations using custom calculations and custom reports.

Minimizing Carryover During Dioxin Analysis Using the Xevo TQ-S with APGC
Library Number: APNT134789354 | Format: PDF | File Size: 799 kB | Year: 2014 | Content Type: Application Notes

In this technology brief, confident and accurate analysis of dioxins and furans can be performed using the prescribed method.

Sensitive and Repeatable Analysis of Pesticides in QuEChERS Extracts with APGC-MS/MS
Library Number: APNT134789863 | Format: PDF | File Size: 1507.47 kB | Year: 2014 | Content Type: Application Notes

In this application note, we demonstrate that the Waters Xevo TQ-S equipped with an APGC source provides a sensitive and repeatable solution for the analysis of pesticides in QuEChERS extracts of strawberry, pear, and spinach.

Chiral and Achiral Profiling of a Pesticide Formulation Using the ACQUITY UPC2 System and the ACQUIT...
Library Number: APNT134790013 | Format: PDF | File Size: 1490.81 kB | Year: 2014 | Content Type: Application Notes

In this application note, we describe the analytical profiling of a triazole containing pesticide formulation using UPC2 and a combination of UV and mass detection.

Selective and Sensitive Screening of Chloramphenicol in Milk Using the ACQUITY UPLC I-Class System a...
Library Number: APNT134790051 | Format: PDF | File Size: 1500.52 kB | Year: 2014 | Content Type: Application Notes

In this application note, we describe an easy to use method that employs mass detection coupled with liquid chromatography for screening chloramphenicol in milk.

Video - Managing Selectivity of Hydrophobic and Hydrophilic Compounds with HILIC and RP-LC
Library Number: APNT134790639 | Format: Web Page | File Size: - | Year: 2014 | Content Type: Application Notes

Dr. Tom Wheat discusses how to use both reversed-phase LC and HILIC modes on the ACQUITY UPLC H-Class System. He also addresses how the ACQUITY QDA Detector enables use of both UV and mass to monitor components with different responses.

Video - Using Small Modifications of pH in Chromatographic Methods Development
Library Number: APNT134790676 | Format: Web Page | File Size: - | Year: 2013 | Content Type: Application Notes

In this video, Paula Hong discusses ways to make the development of chromatographic separations more effective and more efficient by using pH and AutoBlend Plus.

Multi-Residue Pesticide Analysis in Ginseng Powder: Optimized Cleanup After QuEChERS Extraction for ...
Library Number: APNT134790755 | Format: PDF | File Size: 1567.61 kB | Year: 2014 | Content Type: Application Notes

This application note presents QuEChERS extraction and SPE-based cleanup strategies for multi-residue pesticide analysis of American ginseng powder, a highly resinous root material commonly used as an herbal supplement.

A Method for the Rapid and Simultaneous Analysis of Sweeteners in Various Food Products Using the AC...
Library Number: APNT134791123 | Format: PDF | File Size: 1737.95 kB | Year: 2014 | Content Type: Application Notes

In this application note, a fast, reliable, and sensitive method for the identification and quantification of sweeteners has been developed for food and beverage manufacturers.

A Validated Method for the Analysis of 142 Pesticide Residues Using Atmospheric Pressure GC Coupled ...
Library Number: APNT134788107 | Format: PDF | File Size: 1284.6 kB | Year: 2014 | Content Type: Application Notes

In this application note we describe the development and validation of a highly sensitive, multi-class method for the routine determination of 142 pesticide residues in QuEChERS extracts of various fruit and vegetables using APGC and Xevo TQ-S.

Application Notebook: The Path to Successful Drug Development Starts with Purposeful Method Developm...
Library Number: APNT134793711 | Format: PDF | File Size: 13180.52 kB | Year: 2014 | Content Type: Application Notes

This compilation of application notes demonstrates a purposeful approach to method development. Using integrated analytical technologies, standards, and workflows, scientists can produce more robust and reliable methods.

Food Testing Applications Notebook
Library Number: APNT10054185 | Format: PDF | File Size: 3578.58 kB | Year: 2014 | Content Type: Application Notes

This application notebook is a compilation of the most recent applications in the food testing sector.

Multiplexed Analysis of Steroid Hormones Using ionKey/MS
Library Number: APNT134786622 | Format: PDF | File Size: 1227.62 kB | Year: 2014 | Content Type: Application Notes

In this application, we report the use of the newly developed 150 μm ionKey/ MS System for the multiplexed quantitation of 5 important steroid compounds in human serum.

Absolute Quantification of Yeast Kinases by LC/MS/MS using QconCAT and MRM Technologies
Library Number: APNT134780398 | Format: PDF | File Size: 3283.87 kB | Year: 2014 | Content Type: Application Notes

This application note presents the application of label-mediated targeted mass spectrometry to quantify a range of kinases from yeast, spanning a five-order dynamic range.

Biomarker Discovery Directly from Tissue Xenograph Using High Definition Imaging MALDI Combined with...
Library Number: APNT134780407 | Format: PDF | File Size: 7904.91 kB | Year: 2014 | Content Type: Application Notes

In this work, we demonstrate their use with MALDI imaging in studying the changes over time in the proteome on xenograph tissues sections after administration of an anti-cancer drug.

The Use of MassLynx Open Access for LC/MS Accurate Mass Measurements Experiments
Library Number: APNT134780415 | Format: PDF | File Size: 1930.34 kB | Year: 2014 | Content Type: Application Notes

To demonstrate the benefits of using the OpenLynx™ Open Access Application Manager for MassLynx® Software for LC/MS accuate mass measurements experiments.