Literature


Description
Quantitative Analysis of THC and its Metabolites in Whole Blood Using LC-MS/MS for Toxicology and Fo...
Library Number: APNT134901925 | Format: PDF | File Size: 313.84 kB | Year: 2016 | Content Type: Application Notes

This application note details the extraction of THC and its metabolites from whole blood samples using a novel SPE sorbent, Oasis PRiME HLB, in a μElution format for forensic toxicology applications.

High Definition Imaging Software: New “Data Processing” Functionality
Library Number: APNT134901932 | Format: PDF | File Size: 767.47 kB | Year: 2016 | Content Type: Application Notes

This technology brief demonstrates the newly integrated data-processing capability of Waters® High Definition Imaging Software (HDI®).

Profiling Mono and Disaccharides in Milk and Infant Formula Using the ACQUITY Arc System and ACQUITY...
Library Number: APNT134900891 | Format: PDF | File Size: 571.8 kB | Year: 2016 | Content Type: Application Notes

In this application note, learn how the combination of chromatographic retention time and mass information can provide improved selectivity for the profiling of sugars and sugar alcohols.

Analysis of Nucleosides by UltraPerformance Convergence Chromatography (UPC2)
Library Number: APNT134855713 | Format: PDF | File Size: 801.63 kB | Year: 2015 | Content Type: Application Notes

This technology brief demonstrates the advantages of utilizing UltraPerformance Convergence Chromatography™ (UPC2®) to address the analysis of highly polar compounds.

Application of High- and Low-resolution Mass Spectrometers Combined with Nanoscale LC and Microfluid...
Library Number: APNT134900402 | Format: PDF | File Size: 524.52 kB | Year: 2016 | Content Type: Application Notes

This application note presents the comprehensive comparison of both tandem quadrupole and time-of-flight mass spectrometers for the quantitative MRM-based analysis of peptide biomarkers.

Combining RapiFluor-MS and UNIFI Scientific Information System for a Total N-linked Glycan Solution ...
Library Number: APNT134899853 | Format: PDF | File Size: 1736.91 kB | Year: 2016 | Content Type: Application Notes

In this application note, we describe a streamlined N-linked glycan analysis solution for innovator vs. biosimilar comparisons.

Waters 2016 Food Testing Application Notes Booklet
Library Number: APNT134800757 | Format: PDF | File Size: 11822.48 kB | Year: 2016 | Content Type: Application Notes

Read our in-depth application notes to learn about the latest analytical methods for profiling fatty acids, sugars, cinnamon, extractables, veterinary drugs, and pesticides.

Oasis PRiME HLB Cartridge for Cleanup of Infant Formula Extracts Prior to UPLC-MS/MS Multiresidue Ve...
Library Number: APNT134898729 | Format: PDF | File Size: 187.94 kB | Year: 2016 | Content Type: Application Notes

In this application note a simple and effective extraction/protein precipitation procedure was applied to the analysis of infant formula.

CASE STUDY 3: Quantitative and Qualitative Analysis of Perfluoroalkyl Substances (PFASs) in Wildlife...
Library Number: APNT134898813 | Format: PDF | File Size: 1449.68 kB | Year: 2016 | Content Type: Application Notes

In this application note, we demonstrate low-level detection and comprehensive data review of fluorinated environmental contaminants in wildlife using HRMS technologies and an integrated scientific information system.

Highly Analytically Sensitive Analysis of Aldosterone in Plasma on the Xevo TQ-XS for Clinical Resea...
Library Number: APNT134897347 | Format: PDF | File Size: 1005.33 kB | Year: 2016 | Content Type: Application Notes

In this technology brief, the Xevo TQ-XS was used to significantly improve the analytical sensitivity and imprecision of a LC-MS/MS method for the analysis of aldosterone in plasma for clinical research.

Streamline Method Development with Empower 3 MS Peak Tracking
Library Number: APNT134897305 | Format: PDF | File Size: 746.93 kB | Year: 2016 | Content Type: Application Notes

This technology brief demonstrates the use of Empower 3 MS Peak Tracking in the tracking of peak elution during development of a UPLC method for metoclopramide HCl and related substances by mass detection.

Improved Extraction of THC and its Metabolites from Oral Fluid Using Oasis PRiME HLB Solid Phase Ext...
Library Number: APNT134897294 | Format: PDF | File Size: 250.68 kB | Year: 2015 | Content Type: Application Notes

This application note details the extraction and analysis of THC and its major metabolites from oral fluid samples using an Oasis PRiME HLB μElution Plate, followed by UPLC-MS/MS analysis.

Ultimate Resolution HPLC-Based Size Exclusion Chromatography for the Analysis of Small Proteins and ...
Library Number: APNT134841954 | Format: PDF | File Size: 1595.62 kB | Year: 2015 | Content Type: Application Notes

This application note will cover the performance characteristics of this column, designed for the separation of small proteins and peptides, with respect to UPLC method transfer, column-to-column reproducibility, and column stability.

Rapid Screening of Fatty Acids in Oil Supplements Using Ambient Ionization (DART) and Mass Detection
Library Number: APNT134897040 | Format: PDF | File Size: 1509.35 kB | Year: 2016 | Content Type: Application Notes

In this application note, we demonstrate the utility and ease-of-use of DART coupled to single quadrupole mass detection for the identification and rapid authentication of omega-3 and omega-6 polyunsaturated fatty acids in oil supplements.

Rapid Profiling and Authentication of Cinnamon Samples Using Ambient Ionization (DART) and Single Qu...
Library Number: APNT134897051 | Format: PDF | File Size: 1884 kB | Year: 2016 | Content Type: Application Notes

In this application note, we describe a novel approach that employs DART and the ACQUITY QDa Detector for the simple and rapid analysis of cinnamon samples to determine species origin.

Simple, Standardized, and Sensitive Quantification of Bevacizumab (Avastin) Using ProteinWorks eXpre...
Library Number: APNT134873721 | Format: PDF | File Size: 1184.69 kB | Year: 2016 | Content Type: Application Notes

This application note describes the fast, sensitive quantification of bevacizumab from rat plasma using the ProteinWorks eXpress Digest Kit and Protocol.

Quantification of the Antibody Drug Conjugate, Trastuzumab Emtansine, and the Monocolonal Antibody, ...
Library Number: APNT134877891 | Format: PDF | File Size: 1347.63 kB | Year: 2016 | Content Type: Application Notes

This application note describes the total mAb quantification of the ADC, ado-trastuzumab emtansine, and the mAb, trastuzumab from rat plasma using the ProteinWorks eXpress Direct Digest Kit and Protocol.

Increasing Efficiency of Method Validation for Metoclopramide HCl and Related Substances with Empowe...
Library Number: APNT134808554 | Format: PDF | File Size: 2492.32 kB | Year: 2014 | Content Type: Application Notes

We demonstrate the validation of a UPLC method for linearity, detection and quantitation limits, accuracy, repeatability, intermediate precision, specificity, and robustness using Empower 3 Method Validation Manager.

Dwell Volume and Extra-Column Volume: What Are They and How Do They Impact Method Transfer
Library Number: APNT134895769 | Format: PDF | File Size: 1007.76 kB | Year: 2016 | Content Type: Application Notes

The impact of dwell volume & extra-column volume on method transfer is described in this application note.

ACQUITY UPLC PDA Analysis if Biocides (Part 1)
Library Number: APNT134895139 | Format: PDF | File Size: 762.74 kB | Year: 2015 | Content Type: Application Notes

This application note describes a three-minute separation of six biocides using the ACQUITY UPLC PDA System with Empower 3 Software.

Rapid Digestion and Reproducible LC-MS Quantification of Cytochrome C: A Potential Biomarker for Apo...
Library Number: APNT134894215 | Format: PDF | File Size: 477.05 kB | Year: 2016 | Content Type: Application Notes

This application note demonstrates proof of concept for the rapid, accurate and precise quantification of the protein biomarker, cytochrome C.

Process Monitoring of Monoclonal Antibody Subunits for Fast, Critical Quality Attribute Monitoring U...
Library Number: APNT134894031 | Format: PDF | File Size: 742.46 kB | Year: 2016 | Content Type: Application Notes

The scope of the current study is to evaluate the applicability of the ACQUITY QDa Detector for subunit analysis.

Ultra Low-Level Detection of Perfluoroalkyl Substances (PFASs)
Library Number: APNT134893168 | Format: PDF | File Size: 1038.67 kB | Year: 2016 | Content Type: Application Notes

In this technology brief, we describe the detection of routinely monitored PFASs that was performed on the ACQUITY UPLC I-Class System and Xevo TQ-S. Special considerations for the I-Class with flow through needle (FTN) hardware are also detailed.

USP Analysis of Glimepiride on an Alliance HPLC System: Modernization of a USP Method
Library Number: APNT134892351 | Format: PDF | File Size: 247.04 kB | Year: 2016 | Content Type: Application Notes

In this application, the assay for glimepiride was performed according to the USP monograph.

Automated Disulfide Bond Mapping, and Comparing Innovator and Biosimilar mAbs Using UNIFI
Library Number: APNT134892431 | Format: PDF | File Size: 1703.89 kB | Year: 2016 | Content Type: Application Notes

This application note describes a UPLC-MSE analysis of monoclonal antibody (mAb) disulfide bond mapping.