Literature


Description
A Simplified, Mixed-Mode Sample Preparation Strategy for Urinary Forensic Toxicology Screening by UP...
Library Number: APNT134829766 | Format: PDF | File Size: 1562.74 kB | Year: 2015 | Content Type: Application Notes

This application note details a single sample preparation and UPLC®-MS/MS analysis strategy for a comprehensive panel of compounds often analyzed in forensic toxicology screens.

Future Proofing the Biopharmaceutical QC Laboratory: Chromatographic Scaling of HPLC Monosaccharide ...
Library Number: APNT134829823 | Format: PDF | File Size: 1552.35 kB | Year: 2015 | Content Type: Application Notes

In this application note in the series "Furture Proofing the Biopharmaceutical QC Laboratory", we illustrate the transfer of a robust HPLC monosaccharide method to the ACQUITY UPLC H-Class Bio System running as an HPLC, using monosaccharide standards as w...

Separation of Low Levels of Isoleucine from Leucine Using the ACQUITY UPLC H-Class Amino Acid System
Library Number: APNT | Format: PDF | File Size: 1564.01 kB | Year: 2015 | Content Type: Application Notes

Resolution of leucine and isoleucine at levels as low as 0.05% Ile/Leu using the UPLC Amino Acid Analysis Solution.

A Clinical Research Method for the Analysis of Serum Testosterone and Androstenedione
Library Number: APNT134829103 | Format: PDF | File Size: 1851.53 kB | Year: 2015 | Content Type: Application Notes

Here we describe a clinical research method utilizing Oasis MAX μElution Plate Technology for the extraction of testosterone and androstenedione from serum.

UPLC-MS/MS Analysis of Aldosterone in Plasma for Clinical Research
Library Number: APNT134829109 | Format: PDF | File Size: 1710.06 kB | Year: 2015 | Content Type: Application Notes

In this application note we describe a clinical research method utilizing an Oasis MAX μElution Plate for the extraction of aldosterone from plasma.

Analysis of Serum Adrenal Steroids Using the ACQUITY UPLC I-Class with Xevo TQD for Clinical Researc...
Library Number: APNT134829022 | Format: PDF | File Size: 1084.8 kB | Year: 2015 | Content Type: Application Notes

This technology brief demonstrates the analytically sensitive and precise measurement of adrenal steroids from limited-volume clinical research serum samples.

Rapid Preparation of Released N-Glycans for HILIC Analysis Using a Novel Fluorescence and MS-Active ...
Library Number: APNT134829002 | Format: PDF | File Size: 4050.73 kB | Year: 2015 | Content Type: Application Notes

In this application note we have developed a sample preparation solution that enables unprecedented FLR and MS sensitivity for glycan detection while also improving the throughput of N-glycan sample preparation.

Future Proofing the Biopharmaceutical QC Lab: Benefits of Automating Mobile Phase Delivery to Improv...
Library Number: APNT134828919 | Format: PDF | File Size: 1956.32 kB | Year: 2015 | Content Type: Application Notes

In this application note in the transitioning HPLC-based biopharmaceutical separations to UPLC-based methods series described the benefits of automating mobile phase delivery using Auto•Blend Plus Technology.

Adding Mass Detection to Routine Peptide-Level Biotherapeutic Analyses with the ACQUITY QDa Detecto...
Library Number: APNT134828682 | Format: PDF | File Size: 2184.79 kB | Year: 2015 | Content Type: Application Notes

In this work, we demonstrate that the ACQUITY QDa Detector is compatible with conventional LC mobile phases and is able to detect and accurately report mass information for peptides over a wide molecular weight range typical of biotherapeutic peptide maps...

Analysis of Labeled and Non-Labeled Proteomic Data Using Progenesis QI for Proteomics
Library Number: APNT134828388 | Format: PDF | File Size: 2146.85 kB | Year: 2015 | Content Type: Application Notes

The identification and quantification of isotopically-labeled and label-free proteomic data sets were illustrated using Progenesis QI for proteomics solution.

Method Transfer from Agilent 1100 Series LC System to the ACQUITY UPLC H-Class System: The Effect of...
Library Number: APNT134825276 | Format: PDF | File Size: 893.19 kB | Year: 2015 | Content Type: Application Notes

This technology brief demonstrates the comparability of temperature selectivity effects on HPLC method transfer from an Agilent 1100 Series LC System to an ACQUITY UPLC® H-Class System.

Benefits of Using Mass Detection for Analysis of Cetrimonium Bromide Pharmaceutical Raw Material
Library Number: APNT134828296 | Format: PDF | File Size: 2092.98 kB | Year: 2015 | Content Type: Application Notes

This technology brief demonstrates benefits of using ACQUITY UPLC® combined with an ACQUITY® QDa® Detector for rapid raw material testing of cetrimonium bromide, instead of a multistep titrimetric assay.

Performance of ACQUITY UPLC M-Class in Proteomics Nanoscale Applications
Library Number: APNT134827454 | Format: PDF | File Size: 1704.89 kB | Year: 2014 | Content Type: Application Notes

This application note demonstrates the salient performance characteristics of the ACQUITY UPLC M-Class System, reporting typical results from DIA HDMSE acquisitions of a complex, tryptic-peptide sample.

Method Transfer from an Agilent 1100 Series LC System to an ACQUITY UPLC H-Class System with Gradien...
Library Number: APNT134827463 | Format: PDF | File Size: 147.9 kB | Year: 2014 | Content Type: Application Notes

Method Transfer from an Agilent 1100 Series LC System to an ACQUITY UPLC H-Class System with Gradient SmartStart Technology was shown in this application highlight.

Method Transfer from an Agilent 1100 Series LC System to an ACQUITY UPLC H-Class System with Gradien...
Library Number: APNT134826987 | Format: PDF | File Size: 1850.17 kB | Year: 2014 | Content Type: Application Notes

Aim of this study is to transfer a reversed-phase LC gradient method for an API and its related substances from an Agilent 1100 Series LC system to an ACQUITY UPLC® H-Class System.

Analysis of Microcystins RR, LY, and YR in Bottled, Tap, and Surface Water Using ACQUITY UPLC System...
Library Number: APNT134826892 | Format: PDF | File Size: 2453.96 kB | Year: 2014 | Content Type: Application Notes

This application targeted the analysis of microcystin RR, LR, and YR in bottled, tap, and surface water.

Analysis of Rosuvastatin in Dried Blood Spot and Plasma Using ACQUITY UPLC with 2D Technology
Library Number: APNT134826880 | Format: PDF | File Size: 1821.33 kB | Year: 2014 | Content Type: Application Notes

In this application an analysis of rosuvastatin was carried out.

Extraction of Testosterone from Serum using Oasis Max μElution Plates for Clinical Research
Library Number: APNT134826650 | Format: PDF | File Size: 717.25 kB | Year: 2014 | Content Type: Application Notes

This technology brief demonstrates a highly selective solid-phase extraction (SPE) technique with Oasis® MAX μElution Plates for the extraction of testosterone from serum samples for LC-MS/MS analysis in clinical research.

Simultaneous Analysis of Vitamin A and D3 in Vitamin Premixes and Concentrates by Convergence Chroma...
Library Number: APNT134826627 | Format: PDF | File Size: 1509.56 kB | Year: 2014 | Content Type: Application Notes

In this application note, we report a method for analysis of vitamin A and D3 in vitamin premixes and concentrates in one analytical run without purification or dilution.

Rapid Detection and Quantification of Selected Microsomal Substrates and Metabolites Using the Water...
Library Number: APNT134826444 | Format: PDF | File Size: 1789.55 kB | Year: 2014 | Content Type: Application Notes

In the work presented here, we show the development and validation of a rapid and sensitive LC-MS method for the simultaneous detection and quantification of multiple, selected CYP450 substrates and metabolites.

Analysis of Serum 17-Hydroxyprogesterone, Androstenedione, and Cortisol by UPLC-MS/MS for Clinical R...
Library Number: APNT134826301 | Format: PDF | File Size: 1851.72 kB | Year: 2014 | Content Type: Application Notes

In this application note a rapid method for quantification of 17-OHP, cortisol, and A4 was developed using UPLC-MS/MS.

Characterizing of the Natural Product Goldenseal using Cortecs 2.7 μm Columns and ACQUITY QDa Detect...
Library Number: APNT134825070 | Format: PDF | File Size: 1720.1 kB | Year: 2014 | Content Type: Application Notes

In this application, five different sources of Goldenseal which span four different manufacturers, two different parts of the plant, and two different formulation matrices are analyzed.

The Use of HRMS and Statistical Analysis in the Investigation of Basmati Rice Authenticity and Pote...
Library Number: APNT134824425 | Format: PDF | File Size: 3085.14 kB | Year: 2014 | Content Type: Application Notes

A proof of principle method has been established to assess the authenticity of basmati rice samples with the latest advancements in high resolution GC-MS hardware and informatics.

Direct Separations of the Six Positional Isomers of Disubstituted Benzoic Acids Using ACQUITY UPC2 T...
Library Number: APNT134823326 | Format: PDF | File Size: 1733.43 kB | Year: 2014 | Content Type: Application Notes

This study illustrates the rapid and efficient separation of all six of the possible positional isomers of both the six disubstituted dimethoxybenzoic acids and also the six dimethylbenzoic acids (DMBA).

Analysis of Aldosterone in Plasma for Clinical Research using the Xevo TQ-S micro
Library Number: APNT134823344 | Format: PDF | File Size: 525.1 kB | Year: 2014 | Content Type: Application Notes

This technology brief demonstrates the capability of Waters Xevo TQ-S micro mass spectrometer, to quantify low levels of aldosterone in plasma for clinical research using a highly selective sample preparation technique.