Literature


Description
Metabolic Phenotyping Using Atmospheric Pressure Gas Chromatography-MS
Library Number: APNT134832772 | Format: PDF | File Size: 3853.34 kB | Year: 2015 | Content Type: Application Notes

This application note reports an APGC-TOF MSE profiling approach and its application to metabolic fingerprinting of Arabidopsis.

Pesticide Screening of Food Samples Using the ionKey/MS System
Library Number: APNT134787026 | Format: PDF | File Size: 1598.28 kB | Year: 2015 | Content Type: Application Notes

In this application note, The ionKey/MS System, a novel microfluidics-MS platform, was assessed for the micro-LC analysis of pesticides in food samples.

Enantioseparation of Metalaxyl Using ACQUITY UPC2 and Small-Scale Purification Using the Investigato...
Library Number: APNT134832282 | Format: PDF | File Size: 1723.39 kB | Year: 2015 | Content Type: Application Notes

In this application note, we present the chiral resolution of metalaxyl using the ACQUITY UPC2 System, followed by scaling to a semi-preparative purification using the Investigator SFC System.

Characterization of Impurities in the Fungicide Flutriafol Using UNIFI
and UPLC-ToF-MS(E)

Library Number: APNT134832285 | Format: PDF | File Size: 2681.73 kB | Year: 2015 | Content Type: Application Notes

In this application note, the ACQUITY UPLC I-Class System coupled to the Xevo G2-XS QTof and PDA Detector were used to analyze technical-grade flutriafol material.

Generation of Multiple Images from a Single Tissue Section with Dual Polarity Desorption Electrospra...
Library Number: APNT134831781 | Format: PDF | File Size: 2246.84 kB | Year: 2015 | Content Type: Application Notes

This technology brief demonstrates the flexibility of desorption electrospray ionization (DESI) imaging, showing that the same tissue can repeatedly be imaged at the molecular level in positive and negative ion mode, to maximize information about molecula...

Determination of Triphenylmethane Dyes and Their Metabolites in Shrimp Using QuEChERS Extraction and...
Library Number: APNT134831846 | Format: PDF | File Size: 1405.19 kB | Year: 2015 | Content Type: Application Notes

In this application note, we report a highly sensitive and efficient LC-MS/MS method for simultaneously analyzing triphenylmethane (TPM) dyes in shrimp.

Transfer of an Isocratic USP Assay from an Agilent 1100 Series LC System to a ACQUITY UPLC H-Class S...
Library Number: APNT134830915 | Format: PDF | File Size: 1812.79 kB | Year: 2015 | Content Type: Application Notes

In this technology brief an HPLC USP method transfer from an Agilent 1100 Series LC System to an ACQUITY UPLC® H-Class System was demostrated meeting all USP method criteria.

Utility of Desorption Electrospray Ionization (DESI) for Mass Spectrometry Imaging
Library Number: APNT134830937 | Format: PDF | File Size: 1654.08 kB | Year: 2015 | Content Type: Application Notes

This technology brief describes the DESI imaging technique as applied to mass spectrometry imaging using time-of-flight (TOF) mass spectrometers, such as the SYNAPT® G2-Si or the Xevo® G2-XS.

Benefits of Using Mass Detection for Pharmaceutical Raw Materials Analysis of 1-(3-Dimethylaminoprop...
Library Number: APNT134830752 | Format: PDF | File Size: 1797.04 kB | Year: 2015 | Content Type: Application Notes

Here we describe a robust and quick UPLC method for analysis of EDC HCl.

Peptide and Protein Bioanalysis Application Notebook
Library Number: APNT134830620 | Format: PDF | File Size: 19661.64 kB | Year: 2015 | Content Type: Application Notes

This application notebook details on peptide & protein bioanalysis.

Purification of Cannabidiol from Hemp Oil Using the Prep150 LC System
Library Number: APNT134830443 | Format: PDF | File Size: 1844.3 kB | Year: 2015 | Content Type: Application Notes

This application note will describe the purification of Cannabidiol CBD from a CBD-rich paste using the Waters® Prep 150 LC System.

LC-MS/MS Analysis of Pesticide Residues in Rice and Unexpected Detection of Residues in an Organic R...
Library Number: APNT134830407 | Format: PDF | File Size: 1894.98 kB | Year: 2015 | Content Type: Application Notes

In this application note, we describe a rapid, multi-residue method for the determination of over 200 pesticides in basmati rice using a simple QuEChERS sample preparation procedure followed by UPLC-MS-MS.

High Sensitivity Analysis of Opioids in Oral Fluid Using ionKey/MS
Library Number: APNT134830068 | Format: PDF | File Size: 1011.02 kB | Year: 2015 | Content Type: Application Notes

This technology brief demonstrates the separation and high sensitivity detection of opioids in oral fluid using the ionKey/MS System.

Future Proofing the Biopharmaceutical QC Laboratory: Chromatographic Scaling of HPLC Monosaccharide ...
Library Number: APNT134829823 | Format: PDF | File Size: 1552.35 kB | Year: 2015 | Content Type: Application Notes

In this application note in the series "Furture Proofing the Biopharmaceutical QC Laboratory", we illustrate the transfer of a robust HPLC monosaccharide method to the ACQUITY UPLC H-Class Bio System running as an HPLC, using monosaccharide standards as w...

Separation of Low Levels of Isoleucine from Leucine Using the ACQUITY UPLC H-Class Amino Acid System
Library Number: APNT | Format: PDF | File Size: 1564.01 kB | Year: 2015 | Content Type: Application Notes

Resolution of leucine and isoleucine at levels as low as 0.05% Ile/Leu using the UPLC Amino Acid Analysis Solution.

A Simplified, Mixed-Mode Sample Preparation Strategy for Urinary Forensic Toxicology Screening by UP...
Library Number: APNT134829766 | Format: PDF | File Size: 1562.74 kB | Year: 2015 | Content Type: Application Notes

This application note details a single sample preparation and UPLC®-MS/MS analysis strategy for a comprehensive panel of compounds often analyzed in forensic toxicology screens.

A Clinical Research Method for the Analysis of Serum Testosterone and Androstenedione
Library Number: APNT134829103 | Format: PDF | File Size: 1851.53 kB | Year: 2015 | Content Type: Application Notes

Here we describe a clinical research method utilizing Oasis MAX μElution Plate Technology for the extraction of testosterone and androstenedione from serum.

UPLC-MS/MS Analysis of Aldosterone in Plasma for Clinical Research
Library Number: APNT134829109 | Format: PDF | File Size: 1710.06 kB | Year: 2015 | Content Type: Application Notes

In this application note we describe a clinical research method utilizing an Oasis MAX μElution Plate for the extraction of aldosterone from plasma.

Analysis of Serum Adrenal Steroids Using the ACQUITY UPLC I-Class with Xevo TQD for Clinical Researc...
Library Number: APNT134829022 | Format: PDF | File Size: 1084.8 kB | Year: 2015 | Content Type: Application Notes

This technology brief demonstrates the analytically sensitive and precise measurement of adrenal steroids from limited-volume clinical research serum samples.

Rapid Preparation of Released N-Glycans for HILIC Analysis Using a Novel Fluorescence and MS-Active ...
Library Number: APNT134829002 | Format: PDF | File Size: 4050.73 kB | Year: 2015 | Content Type: Application Notes

In this application note we have developed a sample preparation solution that enables unprecedented FLR and MS sensitivity for glycan detection while also improving the throughput of N-glycan sample preparation.

Future Proofing the Biopharmaceutical QC Lab: Benefits of Automating Mobile Phase Delivery to Improv...
Library Number: APNT134828919 | Format: PDF | File Size: 1956.32 kB | Year: 2015 | Content Type: Application Notes

In this application note in the transitioning HPLC-based biopharmaceutical separations to UPLC-based methods series described the benefits of automating mobile phase delivery using Auto•Blend Plus Technology.

Adding Mass Detection to Routine Peptide-Level Biotherapeutic Analyses with the ACQUITY QDa Detecto...
Library Number: APNT134828682 | Format: PDF | File Size: 2184.79 kB | Year: 2015 | Content Type: Application Notes

In this work, we demonstrate that the ACQUITY QDa Detector is compatible with conventional LC mobile phases and is able to detect and accurately report mass information for peptides over a wide molecular weight range typical of biotherapeutic peptide maps...

Analysis of Labeled and Non-Labeled Proteomic Data Using Progenesis QI for Proteomics
Library Number: APNT134828388 | Format: PDF | File Size: 2146.85 kB | Year: 2015 | Content Type: Application Notes

The identification and quantification of isotopically-labeled and label-free proteomic data sets were illustrated using Progenesis QI for proteomics solution.

Benefits of Using Mass Detection for Analysis of Cetrimonium Bromide Pharmaceutical Raw Material
Library Number: APNT134828296 | Format: PDF | File Size: 2092.98 kB | Year: 2015 | Content Type: Application Notes

This technology brief demonstrates benefits of using ACQUITY UPLC® combined with an ACQUITY® QDa® Detector for rapid raw material testing of cetrimonium bromide, instead of a multistep titrimetric assay.

Method Transfer from Agilent 1100 Series LC System to the ACQUITY UPLC H-Class System: The Effect of...
Library Number: APNT134825276 | Format: PDF | File Size: 893.19 kB | Year: 2015 | Content Type: Application Notes

This technology brief demonstrates the comparability of temperature selectivity effects on HPLC method transfer from an Agilent 1100 Series LC System to an ACQUITY UPLC® H-Class System.