Literature


Description
Rapid Digestion and Reproducible LC-MS Quantification of Cytochrome C: A Potential Biomarker for Apo...
Library Number: APNT134894215 | Format: PDF | File Size: 477.05 kB | Year: 2016 | Content Type: Application Notes

This application note demonstrates proof of concept for the rapid, accurate and precise quantification of the protein biomarker, cytochrome C.

Process Monitoring of Monoclonal Antibody Subunits for Fast, Critical Quality Attribute Monitoring U...
Library Number: APNT134894031 | Format: PDF | File Size: 742.46 kB | Year: 2016 | Content Type: Application Notes

The scope of the current study is to evaluate the applicability of the ACQUITY QDa Detector for subunit analysis.

Ultra Low-Level Detection of Perfluoroalkyl Substances (PFASs)
Library Number: APNT134893168 | Format: PDF | File Size: 1038.67 kB | Year: 2016 | Content Type: Application Notes

In this technology brief, we describe the detection of routinely monitored PFASs that was performed on the ACQUITY UPLC I-Class System and Xevo TQ-S. Special considerations for the I-Class with flow through needle (FTN) hardware are also detailed.

USP Analysis of Glimepiride on an Alliance HPLC System: Modernization of a USP Method
Library Number: APNT134892351 | Format: PDF | File Size: 247.04 kB | Year: 2016 | Content Type: Application Notes

In this application, the assay for glimepiride was performed according to the USP monograph.

Automated Disulfide Bond Mapping, and Comparing Innovator and Biosimilar mAbs Using UNIFI
Library Number: APNT134892431 | Format: PDF | File Size: 1703.89 kB | Year: 2016 | Content Type: Application Notes

This application note describes a UPLC-MSE analysis of monoclonal antibody (mAb) disulfide bond mapping.

Pressurized Online Pepsin Digestion of mAb IgG2 for Hydrogen Deuterium Exchange Mass Spectrometry
Library Number: APNT134892458 | Format: PDF | File Size: 462.23 kB | Year: 2016 | Content Type: Application Notes

Here we report an improvement in protein digestion efficiency using a high-pressure, sustainable pepsin column – the Enzymate™ Digestion Column.

Analysis of 17-Hydroxyprogesterone in Serum for Clinical Research
Library Number: APNT134892413 | Format: PDF | File Size: 774.36 kB | Year: 2016 | Content Type: Application Notes

This application note describes a clinical research method utilizing Oasis PRiME HLB μElution Plate technology for the extraction of 17-OHP.

Top-down Monoclonal Antibody (mAb) Analysis Using CID and ETD Fragmentation and the UNIFI Scientific...
Library Number: APNT134891412 | Format: PDF | File Size: 4212.07 kB | Year: 2016 | Content Type: Application Notes

This application note demonstrates the acquisition of protein top-down analysis.

An Improved Workflow for DESI Imaging Mass Spectrometry Incorporating Waters High Definition Imaging...
Library Number: APNT134887440 | Format: PDF | File Size: 1468.41 kB | Year: 2016 | Content Type: Application Notes

This technology brief describes a new software acquisition approach which streamlines DESI imaging workflow to maximize data acquisition.

High Definition Imaging Software: Enhanced Visualization and Overlay of Molecular and Optical Images
Library Number: APNT134890471 | Format: PDF | File Size: 3038.61 kB | Year: 2016 | Content Type: Application Notes

This technology brief highlights the new tools for manipulation of ion and optical image overlays in Waters High Definition Imaging (HDI®) Software version 1.4. This includes tools for alignment and overlay blending modes.

Streamlining Compound Isolation Automatically with UPLC to Prep Chromatography using Mass-Directed A...
Library Number: APNT134890483 | Format: PDF | File Size: 1511.93 kB | Year: 2016 | Content Type: Application Notes

This study illustrates how UPLC system can be dedicated for compound screening and fraction analysis.

Coupling Mass Detection with UV to Improve Method Sensitivity for Esters of Benzenesulfonic Acid in ...
Library Number: APNT134890242 | Format: PDF | File Size: 1234.86 kB | Year: 2016 | Content Type: Application Notes

In this application note, we present a robust and quick UPLC method for analysis of methyl, ethyl, and isopropyl esters of benzenesulfonic acid.

Extractables, Leachables and Food Contact Materials Application Notebook
Library Number: APNT134890337 | Format: PDF | File Size: 6261.98 kB | Year: 2016 | Content Type: Application Notes

Waters provides a wide range of solutions that enable accurate, rapid, and cost effective identification of extractable, leachable, and NIAS contaminants.

Behind the Science, episode 6: Problem Child
Library Number: APNT134890350 | Format: Web Page | File Size: - | Year: 2016 | Content Type: Application Notes

This episode of Behind the Science addresses common problems that scientists face in glycan profiling studies.

Investigating Metal Containing Aggregates in Crude Oil with the ACQUITY APC System
Library Number: APNT134890150 | Format: PDF | File Size: 2138.83 kB | Year: 2016 | Content Type: Application Notes

In this technology brief, learn how the ACQUITY APC System allows the mapping of petroleum samples faster than SEC in order to establish the structure/properties relationship, and enabling the optimization of crude oil refining.

Method Transfer and Reliability of the ACQUITY Arc for Peptide Mapping
Library Number: APNT134875568 | Format: PDF | File Size: 996.19 kB | Year: 2016 | Content Type: Application Notes

This application note demonstrates the method equivalency of a peptide map method when transferred between LC platforms.

High-throughput Screening of Oligonucleotides for Identity and Purity Assessment Using the ACQUITY Q...
Library Number: APNT134889558 | Format: PDF | File Size: 3419 kB | Year: 2016 | Content Type: Application Notes

This application note demonstrates that the ACQUITY QDa Detector provides a simple and cost-effective solution in the assessment of identity and purity of synthetic oligonucleotides.

Single Digit Reproducibility Using ProteinWorks eXpress Digest Kits
Library Number: APNT134874203 | Format: PDF | File Size: 517.26 kB | Year: 2016 | Content Type: Application Notes

To demonstrate the high reproducibility of ProteinWorks™ eXpress Digest Kits resulting from a standardized protocol and pre-weighed, lot-traceable reagents.

LC-MS Quantification of Trastuzumab Using Pellet Digestion and ProteinWorks eXpress Direct Digest Ki...
Library Number: APNT134874215 | Format: PDF | File Size: 940.45 kB | Year: 2016 | Content Type: Application Notes

LC-MS Quantification of Trastuzumab Using Pellet Digestion and ProteinWorks eXpress Direct Digest Kits

Antibody Quantification Using ProteinWorks eXpress Digest Kits
Library Number: APNT134874212 | Format: PDF | File Size: 753.15 kB | Year: 2016 | Content Type: Application Notes

To demonstrate the broad applicability across a range of sample volumes, and the inherent flexibility of the ProteinWorks™ eXpress Direct Digest Kits for the quantification of monoclonal antibody (mAb) drugs by LC-MS/MS.

A Universal, Optimized SPE Protocol for Clean-up of Tryptic Peptides in Protein Bioanalysis
Library Number: APNT134868364 | Format: PDF | File Size: 1519.67 kB | Year: 2015 | Content Type: Application Notes

This technology brief demonstrates the performance of an optimized method for tryptic peptide clean-up in protein bioanalysis.

Using Hydrophilic Interaction Chromatography for Heightened Product Characterization to Overcome Cha...
Library Number: APNT134888711 | Format: PDF | File Size: 1456.4 kB | Year: 2016 | Content Type: Application Notes

This application note describes chromatographic recovery of hydrophobic mAb and antibody drug conjugate (ADC) subunits.

Screening Workflow for Extractables Testing Using the UNIFI Scientific Information System
Library Number: APNT134888897 | Format: PDF | File Size: 2024.23 kB | Year: 2016 | Content Type: Application Notes

This technical note describes a simple workflow and methodology for the screening and characterization of cosmetics, 3D printing media, food, and pharmaceutical packaging extractable applications.

A Fast Efficient Method to Determine the Presence of Nitrosamines in Cosmetics, Personal Care, and C...
Library Number: APNT134888543 | Format: PDF | File Size: 1603.07 kB | Year: 2016 | Content Type: Application Notes

In this application note, we describe the analysis of eight volatile and non-volatile N-nitrosamines previously detected in cosmetics and personal care formulations using the ACQUITY I-Class System and Xevo TQ-S micro.

High Sensitivity Quantification of Infliximab in Rat Plasma Using a Fast, Standardized Kit-Based App...
Library Number: APNT134868864 | Format: PDF | File Size: 1300.26 kB | Year: 2016 | Content Type: Application Notes

This application note describes the fast, sensitive quantification of infliximab from rat plasma using the ProteinWorks eXpress Digest Kit and Protocol.