Literature


Description
Increasing Throughput for the Analysis of Human Insulin and Related Biotherapeutic Analogs using the...
Library Number: APNT134957868 | Format: PDF | File Size: 1037.76 kB | Year: 2017 | Content Type: Application Notes

This study demonstrates highly sensitive, accurate and robust analysis of human insulin and related biotherapeutic analogs.

Analysis of Ergot Alkaloids in Cereal Samples by Liquid Chromatography-Tandem Quadrupole Mass Spectr...
Library Number: APNT134958082 | Format: PDF | File Size: 439.95 kB | Year: 2017 | Content Type: Application Notes

This application note describes a method for the determination of 25 ergot alkaloids (EAs) in cereals using a rapid and simple sample extraction protocol followed by LC-MS/MS on the ACQUITY UPLC System coupled to Xevo TQ-S.

Targeted and Non-Targeted Pesticide Screening Using UPLC-Vion HRMS in Complex Fruit and Vegetable Ma...
Library Number: APNT134957502 | Format: PDF | File Size: 2830.14 kB | Year: 2017 | Content Type: Application Notes

In this application note, the combination of accurate mass data for both parent and fragment ions, isotopic distribution, ion mobility separation, and high quality UPLC separation was used to identify targeted compounds.

An Integrated LC-MS Workflow with ProMass HR for Synthetic Peptide Impurity Analysis
Library Number: APNT134957282 | Format: PDF | File Size: 913.64 kB | Year: 2017 | Content Type: Application Notes

This technology brief demonstrates high-resolution characterization of synthetic peptide impurities.

The Use of ACQUITY UPC2 and the Waters SFC Investigator System for the Analysis, Separation, and Iso...
Library Number: APNT134957068 | Format: PDF | File Size: 1720.37 kB | Year: 2017 | Content Type: Application Notes

This application note demonstrates the separation, purification, and subsequent identification of Canagliflozin and its isomeric impurities.

LC-MS/MS Quantification of Intact Insulin-Like Growth Factor I (IGF-I) in Serum
Library Number: APNT134957115 | Format: PDF | File Size: 393.1 kB | Year: 2017 | Content Type: Application Notes

This application note describes about direct analysis and quantification of intact IGF-I from serum/plasma.

Improving Detection Limits of ADC Free-Drug Impurities Using the ACQUITY QDa Mass Detector
Library Number: APNT134956217 | Format: PDF | File Size: 684.51 kB | Year: 2017 | Content Type: Application Notes

This technology brief demonstrates the Waters® ACQUITY® QDa® Detector can increase the dynamic range and detection limits of UV-based impurity assays for formulated ADC samples.

Forensic Toxicology Application Notebook
Library Number: APNT134770639 | Format: PDF | File Size: 133261.96 kB | Year: 2016 | Content Type: Application Notes

Forensic Toxicology Application Notebook

Measurement of Amino Acids and Acylcarnitines in Dried Bloodspots by Flow-Injection Analysis/Tandem ...
Library Number: APNT134952551 | Format: PDF | File Size: 541.85 kB | Year: 2017 | Content Type: Application Notes

This technology brief demonstrates the rapid quantification of amino acids and acylcarnitines extracted from dried bloodspots.

Determination of Fipronil and its Metabolite Fipronil Sulfone in Eggs by Liquid Chromatography-Tande...
Library Number: APNT134951097 | Format: PDF | File Size: 499.5 kB | Year: 2017 | Content Type: Application Notes

Validated method that meets requirements for both official control and food business operators’ due diligence testing, at concentrations significantly lower than the EU MRL.

Automated Protein Modification Characterization of the Intact and Subunit NIST Monoclonal Antibody R...
Library Number: APNT134949588 | Format: PDF | File Size: 2082.76 kB | Year: 2017 | Content Type: Application Notes

This study demonstrates the use of UNIFI Scientific Information System for mAb modification analysis.

Metabolomic Workflow Utilizing Rapid Microbore Metabolic Processing (RAMMP) in Conjunction with SONA...
Library Number: APNT134949722 | Format: PDF | File Size: 872.02 kB | Year: 2017 | Content Type: Application Notes

Here we demonstrate rapid metabolic profiling workflow with a novel DIA method (SONAR).

Developing Analytical Chromatographic Methods for Pharmaceutical Stability Investigations
Library Number: APNT134949157 | Format: PDF | File Size: 1180.09 kB | Year: 2017 | Content Type: Application Notes

This application describes a case study where a Quality by Design (QbD) approach was used to develop an analytical stability indicating method for monitoring degradation of amoxicillin powder for oral suspension.

Incorporation of Tetrahydrocannabinol into a Mixed Drug Substances Panel – Application to Three Comm...
Library Number: APNT134948888 | Format: PDF | File Size: 306.6 kB | Year: 2017 | Content Type: Application Notes

This technology brief demonstrates the development of a single sample preparation method, using Waters® Oasis® MCX 96-well µElution™ Plate, for the analysis of a mixed drug panel containing Tetrahydrocannabinol (THC) that can be applied to different oral ...

Determination of Vitamin D and Previtamin D in Food Products
Library Number: APNT134948173 | Format: PDF | File Size: 360.49 kB | Year: 2017 | Content Type: Application Notes

This application note demonstrates the determination of total vitamin D by individually measuring the vitamin D and previtamin D in food products.

Fast Analysis of Isoflavones in Dietary Supplements - Method Transfer to the ACQUITY UPLC H-Class Sy...
Library Number: APNT134948178 | Format: PDF | File Size: 362.53 kB | Year: 2017 | Content Type: Application Notes

We have transferred an isoflavones USP method onto an ACQUITY UPLC H-Class System and ACQUITY QDa Mass Detector, shortening the analysis time from 70 min to 8.1 min.

Pressurized Online Pepsin Digestion of mAb IgG2 for Hydrogen Deuterium Exchange Mass Spectrometry
Library Number: APNT134892458 | Format: PDF | File Size: 462.23 kB | Year: 2016 | Content Type: Application Notes

Here we report an improvement in protein digestion efficiency using a high-pressure, sustainable pepsin column – the Enzymate™ Digestion Column.

A Comprehensive Comparison of Solid Phase Extraction (SPE) vs. Solid Liquid Extraction (SLE) vs. Liq...
Library Number: APNT134947936 | Format: PDF | File Size: 407.03 kB | Year: 2017 | Content Type: Application Notes

In this application, a comprehensive comparison of sample preparation techniques conducted in plasma and urine for bioanalysis and forensic toxicology.

Quantitative Determination of Plant Growth Regulators (PGRs) in Grape Matrix Using the Xevo TQD
Library Number: APNT134947858 | Format: PDF | File Size: 862.18 kB | Year: 2017 | Content Type: Application Notes

Using a simple acetonitrile dilution followed by liquidliquid extraction, all pesticides were successfully extracted from the grape matrix and analyzed in an 8 minute run.

Phosphatidylethanol (PEth) – A Direct Biomarker for Ethanol Abuse Analyzed with UPLC-MS/MS for Foren...
Library Number: APNT134946929 | Format: PDF | File Size: 391.67 kB | Year: 2017 | Content Type: Application Notes

An improved chromatographic method for the sensitive measurement of PEth in Whole blood.

An Example of a Particle Selectivity Difference between CORTECS C8 and BEH C8 Columns
Library Number: APNT134946242 | Format: PDF | File Size: 439.51 kB | Year: 2017 | Content Type: Application Notes

The separation of structurally similar compounds is described in this application note.

Effective Determination of Pharmaceutical Impurities by Two Dimensional Liquid Chromatography
Library Number: APNT134946059 | Format: PDF | File Size: 1256.98 kB | Year: 2017 | Content Type: Application Notes

Analysis of API and related impurities is studied using 2DLC.

Improved Multi-Analyte Method for the Underivatized Analysis of Anionic Pesticides in Food by LC-MS/...
Library Number: APNT134945966 | Format: PDF | File Size: 1002.96 kB | Year: 2017 | Content Type: Application Notes

Quantitative determination of an extended suite of eight anionic polar pesticides, which are not amenable to conventional reverse-phase chromatography by LC-MS/MS.

Peptide Separations Application Notebook
Library Number: APNT134916452 | Format: PDF | File Size: 67630.26 kB | Year: 2017 | Content Type: Application Notes

This document is a compilation of published LC & LC-MS applications for the analyses of peptides.

Peptide Separations Application Notebook - Peptide Mapping for Protein Characterization Chapter
Library Number: APNT134923096 | Format: PDF | File Size: 31663.83 kB | Year: 2017 | Content Type: Application Notes

Application notes on peptide mapping for protein characterization.