Literature


Description
An Integrated LC-MS Platform for Multi-Attribute Monitoring of CQA’s of mAbs at the Subunit Level
Library Number: APNT134963558 | Format: PDF | File Size: 1678.45 kB | Year: 2017 | Content Type: Application Notes

This application note demonstrates the use of LC-MS platform under compliant-ready software UNIFI for protein characterization.

Using Mass Detection as an Orthogonal Technology to Improve Routine Analysis of Biotherapeutics
Library Number: APNT134962992 | Format: PDF | File Size: 453.46 kB | Year: 2017 | Content Type: Application Notes

This application note demonstrates how the addition of the ACQUITY QDa can improve the confidence and productivity when carrying out routine analysis of biotherapeutics.

Improving Quantitative Analysis of Red Wine Using the Xevo G2-XS QTof with SONAR Data Independent Ac...
Library Number: APNT134962853 | Format: PDF | File Size: 426.05 kB | Year: 2017 | Content Type: Application Notes

In this technical note we describe the use of a novel data independent acquisition (DIA) mode known as SONAR for generation of highly selective HRMS spectra on Waters Xevo G2-XS QTof.

Analysis of Antidiabetic Drug Canagliflozin and Related Isomeric Impurities Using the ACQUITY UPC2 S...
Library Number: APNT134961702 | Format: PDF | File Size: 729.95 kB | Year: 2017 | Content Type: Application Notes

This application note demonstrates the separation of Canagliflozin and its isomeric impurities.

Characterizing Low Abundance Monoclonal Antibody PTMs Using UNIFI Scientific Information System Pept...
Library Number: APNT134961689 | Format: PDF | File Size: 506.3 kB | Year: 2017 | Content Type: Application Notes

This application not describes peptide PTM analysis using UNIFI with Vion IMS QTof MS system.

Method Modernization for Routine Analysis of Biotherapeutics as Part of Lifecycle Management
Library Number: APNT134961717 | Format: PDF | File Size: 244.65 kB | Year: 2017 | Content Type: Application Notes

This application note describes how the modernization of a USP monograph can increase throughput and productivity in a routine environment.

An Efficient UV-Based Method for the Assessment of Oleic Acid Content in Biotherapeutic Drug Product...
Library Number: APNT134961587 | Format: PDF | File Size: 410.55 kB | Year: 2017 | Content Type: Application Notes

Determination of Oleic Acid concentration in drug products is studied in this app note.

Improved Performance of Waters Alliance HPLC System for System Suitability Results of Area RSD for E...
Library Number: APNT134961208 | Format: PDF | File Size: 132.1 kB | Year: 2017 | Content Type: Application Notes

This application note demonstrates the improved performance of Alliance HPLC system.

Guidelines for the Determination of Compound Recovery on the Waters AutoPurification System
Library Number: APNT134961216 | Format: PDF | File Size: 1010.72 kB | Year: 2017 | Content Type: Application Notes

This application note discusses the guidelines for the determination of compound recovery on Waters AutoPurification System.

Combining Multiple Acquisition Channels for Analysis of Impurities Using Empower 3 Software
Library Number: APNT134961049 | Format: PDF | File Size: 664.94 kB | Year: 2017 | Content Type: Application Notes

This technology brief illustrates use of Empower Software for combining multiple MS SIR channels for analysis of potential genotoxic impurities (PGIs).

Purification Application Notebook
Library Number: APNT134959176 | Format: PDF | File Size: 4994.34 kB | Year: 2017 | Content Type: Application Notes

This note book describes about application solutions for Preparative-Scale Chromatography.

Analysis of Dioxins and Furans on a Xevo G2-XS QTof with APGC Using a QuEChERS Extraction Method
Library Number: APNT134959271 | Format: PDF | File Size: 654.31 kB | Year: 2017 | Content Type: Application Notes

Dioxin method that is faster and more cost effective than the traditional magnetic sector technique using APGC-Xevo G2-XS QTof high resolution mass spectrometry (HRMS) -while exceeding the minimum performance limits required for EPA method 1613.

Metabolite Identification: Working with Large Preclinical Multispecies Data Sets
Library Number: APNT134959055 | Format: PDF | File Size: 2461.57 kB | Year: 2017 | Content Type: Application Notes

This application note outlines the use of integrated quantitative and qualitative processing for managing multispecies studies.

Integrating Ion Mobility into Routine Metabolite Identification Studies Using the Vion IMS QTof Mass...
Library Number: APNT134956341 | Format: PDF | File Size: 929.81 kB | Year: 2017 | Content Type: Application Notes

This application note outlines and focuses on the benefits and the ease of use of ion mobility for the application of metabolite identification.

Increasing Throughput for the Analysis of Human Insulin and Related Biotherapeutic Analogs using the...
Library Number: APNT134957868 | Format: PDF | File Size: 1037.76 kB | Year: 2017 | Content Type: Application Notes

This study demonstrates highly sensitive, accurate and robust analysis of human insulin and related biotherapeutic analogs.

Analysis of Ergot Alkaloids in Cereal Samples by Liquid Chromatography-Tandem Quadrupole Mass Spectr...
Library Number: APNT134958082 | Format: PDF | File Size: 439.95 kB | Year: 2017 | Content Type: Application Notes

This application note describes a method for the determination of 25 ergot alkaloids (EAs) in cereals using a rapid and simple sample extraction protocol followed by LC-MS/MS on the ACQUITY UPLC System coupled to Xevo TQ-S.

Targeted and Non-Targeted Pesticide Screening Using UPLC-Vion HRMS in Complex Fruit and Vegetable Ma...
Library Number: APNT134957502 | Format: PDF | File Size: 2830.14 kB | Year: 2017 | Content Type: Application Notes

In this application note, the combination of accurate mass data for both parent and fragment ions, isotopic distribution, ion mobility separation, and high quality UPLC separation was used to identify targeted compounds.

An Integrated LC-MS Workflow with ProMass HR for Synthetic Peptide Impurity Analysis
Library Number: APNT134957282 | Format: PDF | File Size: 913.64 kB | Year: 2017 | Content Type: Application Notes

This technology brief demonstrates high-resolution characterization of synthetic peptide impurities.

The Use of ACQUITY UPC2 and the Waters SFC Investigator System for the Analysis, Separation, and Iso...
Library Number: APNT134957068 | Format: PDF | File Size: 1720.37 kB | Year: 2017 | Content Type: Application Notes

This application note demonstrates the separation, purification, and subsequent identification of Canagliflozin and its isomeric impurities.

LC-MS/MS Quantification of Intact Insulin-Like Growth Factor I (IGF-I) in Serum
Library Number: APNT134957115 | Format: PDF | File Size: 393.1 kB | Year: 2017 | Content Type: Application Notes

This application note describes about direct analysis and quantification of intact IGF-I from serum/plasma.

Improving Detection Limits of ADC Free-Drug Impurities Using the ACQUITY QDa Mass Detector
Library Number: APNT134956217 | Format: PDF | File Size: 684.51 kB | Year: 2017 | Content Type: Application Notes

This technology brief demonstrates the Waters® ACQUITY® QDa® Detector can increase the dynamic range and detection limits of UV-based impurity assays for formulated ADC samples.

Forensic Toxicology Application Notebook
Library Number: APNT134770639 | Format: PDF | File Size: 133261.96 kB | Year: 2016 | Content Type: Application Notes

Forensic Toxicology Application Notebook

Measurement of Amino Acids and Acylcarnitines in Dried Bloodspots by Flow-Injection Analysis/Tandem ...
Library Number: APNT134952551 | Format: PDF | File Size: 541.85 kB | Year: 2017 | Content Type: Application Notes

This technology brief demonstrates the rapid quantification of amino acids and acylcarnitines extracted from dried bloodspots.

Determination of Fipronil and its Metabolite Fipronil Sulfone in Eggs by Liquid Chromatography-Tande...
Library Number: APNT134951097 | Format: PDF | File Size: 499.5 kB | Year: 2017 | Content Type: Application Notes

Validated method that meets requirements for both official control and food business operators’ due diligence testing, at concentrations significantly lower than the EU MRL.

Automated Protein Modification Characterization of the Intact and Subunit NIST Monoclonal Antibody R...
Library Number: APNT134949588 | Format: PDF | File Size: 2082.76 kB | Year: 2017 | Content Type: Application Notes

This study demonstrates the use of UNIFI Scientific Information System for mAb modification analysis.