LC-MS Characterization of mAb Subunits Using a BioResolve RP mAb Column

Library Number:
APNT134966192
Part Number:
720006199EN
Author(s):
Nilini Ranbaduge, Henry Shion, Matthew A. Lauber, and Ying Qing Yu
Source:
Waters
Content Type:
Application Notes
Content Subtype:
Technical Notes
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In this technical brief, the BioResolve RP mAb Polyphenyl Column is shown to be able to facilitate improved mAb subunit separations. The column is shown to be used with conventional RPLC-MS methodologies to improve the capabilities of subunit-level analysis. With enhanced chromatographic resolution and through careful optimization of mass loads, it has been possible to better clarify sample heterogeneity providing more insight into mAb structure and function.


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