High-Resolution Separation of Intact Antibodies Using BioResolve RP mAb Polyphenyl Columns

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Ximo Zhang, Robert Birdsall, and Ying Qing Yu
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Application Notes
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Application Notes
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This application note provides a high-resolution, reversed-phase based separation method for intact antibodies that take advantage of the purposefully-designed capabilities of the BioResolve RP mAb Polyphenyl Column. Using optimized, silica-based, solid-core particles that are surrounded by a porous layer containing 450Å pores with novel polyphenyl bonded phase, the BioResolve RP mAb Polyphenyl Column increases the efficiency and selectivity of intact antibody separations. This results in improvements in resolution, peak width, peak shape, and carryover compared to current leading porous and non-porous column technologies.

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