Efficient and Clean Extraction of a Multi-Drug Panel with Oasis PRiME MCX for Clinical Research

Library Number:
APNT134965885
Part Number:
720006196EN
Author(s):
Jonathan Danaceau, Kim Haynes, and Lisa J. Calton
Source:
Waters
Content Type:
Application Notes
Content Subtype:
Application Notes
Related Products:
 
 
 
 

This application note highlights the use of Oasis PRiME MCX using a multi-drug panel containing opioids, benzodiazepines, stimulants, anti-epileptics, synthetic cathinones, and other compounds to demonstrate the simplicity and cleanliness achieved with this product for clinical research.

Using Oasis PRiME MCX, efficient and reproducible recovery of bases from biological samples can be achieved that is equivalent to Oasis MCX for clinical research. At the same time, residual phospholipids can be reduced by 98% compared to conventional Oasis MCX protocols and can even be lower than those achieved with Oasis PRiME HLB. Thus, the advantages of phospholipid removal are combined with the specificity and selectivity of a mixed-mode polymeric SPE sorbent.


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