UPLC-MS/MS Analysis of Oncology Drugs in Plasma for Clinical Research

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Stephen Balloch, Gareth Hammond and Lisa Calton
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Here we describe separate UPLC-MS/MS methods for plasma busulfan and 5-fluorouracil (5-FU) for clinical research applications using an ACQUITY® UPLC® I-Class-FTN and Xevo® TQ-XS mass spectrometer. Following CLSI guidelines, carryover, linearity, matrix effects, precision and specificity were evaluated. Additionally, a comparison was performed for busulfan with an independent method. Analytically  sensitive and specific methods may play a role in assessing the pharmacokinetic and pharmacodynamic effects of administration of these drugs in clinical research.

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