Characterizing Low Abundance Monoclonal Antibody PTMs Using UNIFI Scientific Information System Peptide Mapping DDA Workflow

Library Number:
APNT134961689
Part Number:
720006134EN
Author(s):
Jing Fang, Ying Qing Yu, and Weibin Chen
Source:
Waters
Content Type:
Application Notes
Content Subtype:
Application Notes
Related Products:
 
 
 

In this study, we describe an optimized DDA method for peptide PTM analysis using the UNIFI Scientific Information System with the Vion IMS QTof MS especially for low abundant peptides with interference from co-eluting peptides. The high sensitivity and high dynamic range specifications of the Vion IMS QTof enable high quality MS/MS data for low abundant peptides and accurate quantitation. MSE combined DDA methods meet all the requirements in peptide mapping qualitatively and quantitatively.


Title Format File Size
Download PDF PDF 506.3kB