Analysis of 5-Fluorouracil in Plasma for Clinical Research

Library Number:
APNT134945127
Part Number:
720006049EN
Author(s):
Stephen Balloch, Lisa Calton, and Gareth Hammond
Source:
Waters
Content Type:
Application Notes
Content Subtype:
Technical Notes
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Here we describe a clinical research method using liquid-liquid extraction of plasma with 5-fluorouracil-13C15N2 internal standard. Chromatography was achieved within 3 minutes using a Waters® ACQUITY UPLC® HSS PFP Column (2.1 x 100 mm, 1.8 μm) on a ACQUITY UPLC I-Class System followed by detection on a Xevo® TQD Mass Spectrometer


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