On-demand video webinar: Petur Weihe Dalsgaard, Section of Forensic Chemistry, University of Copenhagen, discusses how high resolution mass spectrometry is now increasingly used in forensic toxicology laboratories for screening applications. The ability to perform comprehensive and "untargeted" screening enables toxicology laboratories to screen for very large number of compounds in a single analytical run. A particular strength of high resolution mass spectrometers operating in data independent acquisition (DIA) modes such as MSE is the ability to acquire accurate mass spectrometry data on all precursor and fragment ions present in a sample. This enables confident identification of "expected components" by comparison with library data and retrospective investigation of to detect and identify novel psychoactive substances for which standards are difficult to obtain.
For high resolution mass spectrometry to become accessible to the routine toxicology laboratory, powerful and easy to use informatics is essential to process the large volume of data produced and successfully detect and identify components. This webinar will present on the use time of flight technology working in MSE mode and the Waters UNIFI Scientific Information System for targeted, semi targeted and untargeted screening.