Consumer concerns and federal regulations make pesticide residue analysis an important component of ensuring food safety. It is desirable to rapidly and reliably screen samples for a large number of pesticides in as few methods as possible. Comprehensive pesticide screening is typically performed using LC and GC techniques on dedicated MS platforms. For this analysis, UPLC-MS/MS and APGC-MS/MS pesticide residue analysis was performed on a single mass spectrometer, with changeover time from LC-MS/MS to GC-MS/MS of less than 30 minutes. The same sample extracts prepared from fruit and vegetable commodities were run on both chromatography systems that were coupled to the same tandem quadrupole MS. Each method targeted a list of approximately 200 compounds, monitoring for at least two MRM transitions for each compound. Standards for data quality were taken from the SANTE Guidelines (11945/2015). In the four matrices analyzed, >96% of compounds were detected at 10 µg/kg, with a majority of compounds detectable below 1 µg/kg on both UPLC and APGC. The coefficient of determination in matrix matched calibration curves were generally > 0.995 and ion ratios fell within 30% of the reference value. The RSD was < 10% for upwards of 90% of the compounds detected at 10 µg/kg. The data presented demonstrates the ability to increase compound coverage on a single MS with the flexibility and reliability of performing UPLC-MS/MS and APGC-MS/MS for routine multiresidue pesticide analysis.