Metabolomic Workflow Utilizing Rapid Microbore Metabolic Processing (RAMMP) in Conjunction with SONAR
This application note demonstrates improvements to the metabolic profiling workflow by coupling RAMMP with a novel DIA method (SONAR), providing highly specific and unbiased two-dimensional metabolomic data.
- SONAR™ DIA is utilized with a rapid metabolic processing workflow (within 3 minute gradients)
- The fast scanning capabilities of SONAR demonstrates quantitative precision for high throughput, large cohort experiments
- Optimization of the quadrupole isolation window provides improved specificity
- Rapid metabolomic analysis of urine from a pregnant cohort over three trimesters shows applicability of the method with clear differentiation of each trimester