Improved Multi-Analyte Method for the Underivatized Analysis of Anionic Pesticides in Food by LC-MS/MS

Library Number:
APNT134945966
Part Number:
720006070en
Author(s):
Benjamin Wuyts, Euan Ross, Simon Hird, and Dimple Shah
Source:
Waters
Content Type:
Application Notes
Content Subtype:
Application Notes
Related Products:
 
 
 
 

Expanding on previous work, this application note describes the quantitative determination of an extended suite of eight anionic polar pesticides, which are not amenable to conventional reverse-phase chromatography by LC-MS/MS. A hydrophilic interaction chromatography (HILIC)-based analytical column was used without the need for derivatization or specialty ion chromatography equipment.

Application benefits include:

  • Underivatized analysis of anionic polar pesticides in food
  • Excellent sensitivity and precision
  • Satisfactory chromatographic performance on routine LC-MS/MS system
  • Accurate quantitation of residues in the absence of isotopically labeled internal standards.

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